Abstract：
:The effects of 1 min of acute hypoxic treatment (1% O2 in N2) on incorporation of [1-14C]arachidonic acid into brain lipids of 16-day-old rats were investigated at 3, 6, and 12 min after intracerebral injection of the labeled fatty acid. The hypoxic-hypoxia condition associated with convulsive seizures caused a decrease in the conversion of labeled arachidonate to its acyl-CoA as well as incorporation of the label into the brain phospholipids. Among the phospholipids, there was a specific decrease in the labeling of diacylglycerophosphoinositol (GPI), and this change was accompanied by an increase in labeling of the diacylglycerols. These results indicate that metabolism of the long-chain fatty acids and some glycerolipids in brain are vulnerable to acute hypoxic treatment.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Strosznajder J,Sun GYdoi
10.1007/BF00965474subject
Has Abstractpub_date
1981-07-01 00:00:00pages
767-74issue
7eissn
0364-3190issn
1573-6903journal_volume
6pub_type
杂志文章abstract：:The microdialysis technique was used to study the effect of nitric oxide synthase (NOS) activity on taurine release. Taurine release was characterized in rat striatum that was excitotoxically lesioned compared to normal conditions. The basal taurine level of the dialysate decreased during quinolinate (QUIN) lesion in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022418231496
更新日期：1998-04-01 00:00:00
abstract：:Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN). Mechanistic evidence of this role has previously only been provided through transcriptional or translational depletion of total APP levels. However, numer...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02747-y
更新日期：2019-06-01 00:00:00
abstract：:The present study reports inhibition of taurine uptake in the rat retina in vitro to 49% of control by 1 mM guanidinoethyl sulfonate. No efflux of preloaded [14C]taurine was observed by incubation in the presence of guanidinoethyl sulfonate. The in vivo depletion of retinal taurine by guanidinoethyl sulfonate treatmen...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964157
更新日期：1983-12-01 00:00:00
abstract：:Developing cellular models of sporadic Alzheimer's disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells (iPSCs) has revolutionised the opportunities to model AD pathology, in...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-018-2663-z
更新日期：2018-12-01 00:00:00
abstract：:Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1025678510480
更新日期：2003-10-01 00:00:00
abstract：:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0172-9
更新日期：2010-08-01 00:00:00
abstract：:The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2441-3
更新日期：2018-01-01 00:00:00
abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02734-3
更新日期：2019-04-01 00:00:00
abstract：:The nerve agent VX has a variable and delayed absorption through the skin, which may have implications for treatment regimens. In the present study, central and peripheral effects of percutaneous VX intoxication were investigated in hairless guinea pigs. Although onset times of clinical signs varied considerably, the ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9508-5
更新日期：2008-02-01 00:00:00
abstract：:The regional distribution of 2-amino-4-phosphonobutyrate (APB)/chloride-insensitive L-[3H]glutamate binding sites in the rat central nervous system was compared with that of APB/chloride-sensitive and with sodium-dependent binding sites. The distribution of APB-sensitive and APB-insensitive sites was not correlated, b...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963986
更新日期：1984-03-01 00:00:00
abstract：:Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965830
更新日期：1991-01-01 00:00:00
abstract：:The effect of phenobarbital (100 mg/kg i.p.) and 6-aminonicotinamide (6AN) (35 mg/kg i.p.) on enzyme activities related to energy transduction was investigated on the homogenate "in toto", non-synaptic mitochondrial fraction and synaptosomal fraction isolated from different rat brain areas (cerebral cortex, hippocampu...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971361
更新日期：1987-01-01 00:00:00
abstract：:Astrocytes have been considered to be transformed from radial glial cells that appear at early stage of development and play a scaffold-role for neuronal cell migration. Recent studies indicate that neuroepithelial cells in the spinal cord also give rise to astrocytes. However, the mode of astroglial generation and mi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9590-3
更新日期：2008-07-01 00:00:00
abstract：:Nitric oxide (NO) regulates numerous physiological process and is the main source of reactive nitrogen species (RNS). NO promotes cell survival, but it also induces apoptotic death having been involved in the pathogenesis of several neurodegenerative diseases. NO and superoxide anion react to form peroxynitrite, which...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1805-9
更新日期：2016-02-01 00:00:00
abstract：:Mouse isolated vas deferens preincubated with [3-H]noradrenaline was superfused and the effect of alpha 1-adrenoceptor agonists was studied on the release of total radioactivity ([3H]noradrenaline + 3H-metabolites) and [3H]noradrenaline. Reverse phase high pressure liquid chromatography (HPLC) combined with scintillat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965167
更新日期：1986-01-01 00:00:00
abstract：:Protein kinase C (PKC) plays a key role in cellular events including proliferation, survival and differentiation. Our previous study showed the effect of phorbol 12-myristate 13-acetate (PMA), a PKC activator, inducing a decrease in retinal cells proliferation. This effect was mediated by muscarinic type 1 receptors (...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9847-x
更新日期：2009-05-01 00:00:00
abstract：:To assess the therapeutic effects of microRNA-21 (miR-21) knockdown (KD) for acute thoracic spinal cord contusion using a mouse model. Forty C57/BL6 mice were randomly divided into four groups: mice in the sham-operated (Sham) group received surgical procedure without spinal cord contusion; the spinal cord injury (SCI...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2580-1
更新日期：2018-08-01 00:00:00
abstract：:Parkinson's disease (PD) is a severe neurodegenerative disease characterized by selective loss of dopaminergic neurons, which reduces quality of life of patients and poses a heavy burden to the society. The pathological mechanism of PD remains unclear, and increasing efforts are aimed to solve this problem. MiRNAs are...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03166-0
更新日期：2020-11-12 00:00:00
abstract：:The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965738
更新日期：1990-10-01 00:00:00
abstract：:Agonist occupancy of muscarinic cholinergic receptors in human SH-SY-5Y neuroblastoma cells elicited two kinetically distinct phases of phosphoinositide hydrolysis when monitored by either an increased mass of inositol 1,4,5-trisphosphate, or the accumulation of a total inositol phosphate fraction. Within 5s of the ad...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971329
更新日期：1994-05-01 00:00:00
abstract：:After rapid inactivation of the enzymes responsible for glucose metabolism by microwave irradiation, concentrations of glucose in 20 regions of the mouse brain were estimated with combined gas chromatography-mass spectrometry (GC-MS). The highest concentrations of glucose were found in the periventricular nuclei of th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963774
更新日期：1977-12-01 00:00:00
abstract：:We have previously shown that peptide neurotensin inhibits cerebral cortex synaptosomal membrane Na+, K+-ATPase, an effect fully prevented by blockade of neurotensin NT1 receptor by antagonist SR 48692. The work was extended to analyze neurotensin effect on Na+, K+-ATPase activity present in other synaptosomal membran...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021612825025
更新日期：2002-11-01 00:00:00
abstract：:Post-ischemic changes in energy metabolites and natural antioxidant compounds have been measured in rat brain in vitro concurrent with two different assays for peroxidized lipids. No exogenous free radical initiators were employed. In vitro oxygenation of minced brain preparations for periods of 10 minutes to 4 hours,...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965496
更新日期：1982-04-01 00:00:00
abstract：:The neuropathy associated with diabetes includes well documented impairment of axonal transport, a reduction in axon calibre and a reduced capacity for nerve regeneration. All of those aspects of nerve function rely on the integrity of the axonal cytoskeleton. Alterations in the axonal cytoskeleton in experimental dia...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022466624223
更新日期：1997-08-01 00:00:00
abstract：:Status epilepticus (SE) is a severe clinical manifestation of epilepsy associated with intense neuronal loss and inflammation, two key factors involved in the pathophysiology of temporal lobe epilepsy. Bone marrow mononuclear cells (BMMC) attenuated the consequences of pilocarpine-induced SE, including neuronal loss, ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1217-7
更新日期：2014-02-01 00:00:00
abstract：:There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced an...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2253-5
更新日期：2017-07-01 00:00:00
abstract：:Two major glycoproteins, P0 and PASII/PMP22, are specifically expressed in peripheral myelin. Point mutations of these proteins and over or under expression of PASII/PMP22 cause various hereditary peripheral neuropathies. P0 is well characterized as a major adhesion molecule in PNS myelin, but the function of PASII/PM...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1010927001378
更新日期：2001-06-01 00:00:00
abstract：:A previously described inhibitor of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyltransferase (GalNAc-T) (Quiroga et al., 1, 2), was purified from chicken blood serum by a new procedure. When subjected to SDS-PAGE, two major polypeptides of 27 and 70 kDa were observed. When tested in vitro, only the 27 kDa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027320113151
更新日期：1997-04-01 00:00:00
abstract：:Cerebral blood flow (CBF) and cerebellar blood flow (CeBF) were measured and correlated with brain lactate, pyruvate and adenosine triphosphate concentrations from groups representing 3-week old suckling (n = 10), 18-22-week old adult (n = 9) and 70-week old aged (n = 7) Sprague-Dawley rats before and during bilateral...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027321203294
更新日期：1997-01-01 00:00:00
abstract：:In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different ages with several types of aging brain disorders. When compared with ac...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532336
更新日期：1996-08-01 00:00:00
