A metabolic basis for Alzheimer disease.

Abstract:

:Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.

journal_name

Neurochem Res

journal_title

Neurochemical research

authors

Perry G,Nunomura A,Raina AK,Aliev G,Siedlak SL,Harris PL,Casadesus G,Petersen RB,Bligh-Glover W,Balraj E,Petot GJ,Smith MA

doi

10.1023/a:1025678510480

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1549-52

issue

10

eissn

0364-3190

issn

1573-6903

journal_volume

28

pub_type

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