Abstract：
:In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different ages with several types of aging brain disorders. When compared with activities in the normal population, we have detected: 1) SOD and CAT activities are decreased in patients with Parkinson disease. 2) SOD activity seems to be normal and CAT activity is decreased in patients with dementia. 3) In the patients with stroke, SOD activity is normal, while CAT activity is decreased. SOD activity was measured in red blood cells using the Minami and Yoshikawa method. CAT activity was measured in hemolysates by the method of Aebi. We can conclude that SOD and CAT activities in patients with Parkinson disease are decreased.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
de la Torre MR,Casado A,López-Fernández ME,Carrascosa D,Casado MC,Venarucci D,Venarucci Vdoi
10.1007/BF02532336subject
Has Abstractpub_date
1996-08-01 00:00:00pages
885-8issue
8eissn
0364-3190issn
1573-6903journal_volume
21pub_type
杂志文章abstract：:The kinetics of the uptake of p-tyramine, m-tyramine, and dopamine were investigated in slices of the hypothalamus and striatum of the rat in the presence of nialamide. When uptake was analyzed by a least-squares fit to a Lineweaver-Burk plot, each amine appeared to be concentrated by both a "low"-affinity and a "high...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964440
更新日期：1979-10-01 00:00:00
abstract：:Bovine brain synaptic membranes which were frozen and then extensively washed showed low affinity [3H]muscimol binding. These membranes contained GABA and calmodulin, apparently tightly bound within the membrane fraction. Membranes which were additionally treated with the detergent Triton X-100 showed high affinity [3...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970756
更新日期：1988-09-01 00:00:00
abstract：:Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports i...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-016-1853-9
更新日期：2016-06-01 00:00:00
abstract：:The significant increase of free calcium concentration ([Ca2+]i) was found in rat cerebral cortex synaptosomes and hippocampal crude synaptosomal fraction after their exposure to glutamate. But no change of [Ca2+]i was revealed in cerebellar synaptosomes, the slight increase of [Ca2+]i in striatal synaptosomes was not...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020752101736
更新日期：1999-09-01 00:00:00
abstract：:The pathophysiological mechanism(s) underlying Alzheimer's disease (AD) still remain unclear, and no disease-modifying or prophylactic therapies are currently available. Unraveling the fundamental neuropathogenesis of AD is an important challenge. Several studies on AD have suggested lesions in a number of CNS areas i...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-011-0680-2
更新日期：2012-04-01 00:00:00
abstract：:Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9311-3
更新日期：2007-08-01 00:00:00
abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0203-6
更新日期：2010-09-01 00:00:00
abstract：:Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007632326953
更新日期：2000-11-01 00:00:00
abstract：:Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide a...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF00965847
更新日期：1991-09-01 00:00:00
abstract：:The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9763-0
更新日期：2009-02-01 00:00:00
abstract：:During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9506-7
更新日期：2008-04-01 00:00:00
abstract：:Several lines of evidence suggest that the mechanism underlying drug-induced neuronal apoptosis is initiated by the increased production of reactive oxygen species (ROS). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin, has been shown to initiate an apoptotic cascade by increasing ROS in the dopamine...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1208-8
更新日期：2014-02-01 00:00:00
abstract：:Rabbits sensitized with whole nervous tissue or myelin basic protein (MBP) plus adjuvant and developing experimental allergic encephalomyelitis (EAE) were studied for the presence of oligoclonal immunoglobulin (Ig) bands in spinal fluid and serum. Samples obtained prior to sensitization and at the time of sacrifice we...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963909
更新日期：1981-01-01 00:00:00
abstract：:During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-015-1545-x
更新日期：2015-12-01 00:00:00
abstract：:In our previous study vesamicol, an inhibitor of the acetylcholine transporter of the cholinergic vesicles, inhibited veratridine-evoked external Ca(2+)-dependent acetylcholine release from striatal slices but did not influence acetylcholine release observed in Ca(2+)-free medium (4). Here we examined if the effect of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968780
更新日期：1992-06-01 00:00:00
abstract：:"Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model of temporal lobe epilepsy. At the present work we investigated the contribution of NMDA receptors in the Pentylenetetrazol-induced "kindling" model in the mouse brain, by using quantitative autoradiography and the radioa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021143813935
更新日期：1999-12-01 00:00:00
abstract：:Microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as Alzheimer disease. Mounting evidence points to ion channels expressed by microglia as contributing to these neuropathologies. The Chloride Intracellular Channel (CLIC) family represent...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1084-2
更新日期：2013-09-01 00:00:00
abstract：:An efficient exchange of lactate between different cell types (such as astrocytes and neurones) would require that lactate transporters are expressed in contiguous parts of the respective plasma membranes. To settle this issue we explored the subcellular expression pattern of monocarboxylate transporters (MCTs) by use...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1014806723147
更新日期：2002-02-01 00:00:00
abstract：:The levels of selected neuroregulatory proteins that inhibit or promote apoptotic cell death were measured in the striatum of piglets subjected to precisely controlled 1 h hypoxic insult followed by 0, 2 and 4 h recovery and compared to sham operated animals. The anti-apoptotic proteins: there were increases in Surviv...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0394-x
更新日期：2011-05-01 00:00:00
abstract：:Hyperprolinemia type II (HPII) is an autosomal recessive disorder caused by the severe deficiency of enzyme delta1-pyrroline-5-carboxylic acid dehydrogenase leading to tissue accumulation of proline. Chronic administration of Pro led to significant reduction of cytosolic ALT activity of olfactory lobes (50.57%), cereb...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-7026-2
更新日期：2004-12-01 00:00:00
abstract：:Ion channels are targets of various antiepileptic drugs. In cerebral presynaptic nerve endings Na(+) and Ca(2+) channels are particularly abundant, as they control neurotransmitter release, including the release of glutamate (Glu), the most concentrated excitatory amino acid neurotransmitter in the brain. Several pre-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1749-0
更新日期：2016-04-01 00:00:00
abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-006-9128-5
更新日期：2007-04-01 00:00:00
abstract：:Docosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood-brain barrier permeability and maintaining its integrity, accompanied by an increased Ang-1/Ang-2 ratio; however, the underlying mechanisms of these effects remain unclear. Src-suppressed C kinase substrates (SSeCKS), a sub...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02915-0
更新日期：2020-02-01 00:00:00
abstract：:Ochratoxin A (OA) is a mycotoxin produced by several storage fungi, such as Aspergillus ochraceus and several Penicillium species. OA (3 mg/kg) was given intraperitoneally to pregnant mice on day 11 of gestation (day 1 = day of insemination), and neurochemical changes in brains of their offspring were examined at feta...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971631
更新日期：1988-12-01 00:00:00
abstract：:It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020937728506
更新日期：2002-10-01 00:00:00
abstract：:Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2284-y
更新日期：2018-01-01 00:00:00
abstract：:Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure can produce long-lasting damage to adult brains, despite post-exposure ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1548-7
更新日期：2015-10-01 00:00:00
abstract：:Estrogen action is necessary for evidencing the stimulatory action of mifepristone and naloxone on prolactin (PRL) secretion during late pregnancy. Our aim is to determine the mechanism mediating this facilitator action of estrogens. To investigate the hypothalamic mechanisms involved in estrogen actions in PRL secret...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2067-x
更新日期：2016-12-01 00:00:00
abstract：:The search for neuronotrophic factors addressing CNS neurons requires CNS neuronal cell cultures to quantitate putative effects on neuronal survival. Investigation of neurons dissociated from several embryonic CNS tissues have shown that their short-term survival requires supplementation of the culture medium with eit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973276
更新日期：1988-07-01 00:00:00
abstract：:Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965512
更新日期：1989-12-01 00:00:00
