Functional analysis for peripheral myelin protein PASII/PMP22: is it a member of claudin superfamily?

abstract：:Dual-specificity tyrosine-regulated kinase 2 (DYRK2), a protein kinase that phosphorylates its substrates on serine/threonine, is expressed in numerous human tumors, but little is known about its role in the pathophysiology of glioma. In this study, we made an effort to explore the expression and function in human gli...

journal_title：Neurochemical research

authors： Shen Y,Zhang L,Wang D,Bao Y,Liu C,Xu Z,Huang W,Cheng C

更新日期：2017-11-01 00:00:00

abstract：:Mitochondrially bound brain hexokinase is solubilized by anesthetics and this effect has been suggested to contribute to anesthesia. In the present investigation the influence of the metabolic inhibitor 2-deoxy-D-glucose (2-DOG) was studied. An isolated rat brain preparation was used to avoid the contribution of perip...

journal_title：Neurochemical research

authors： Krieglstein J,Sperling G,Stock R

更新日期：1982-06-01 00:00:00

abstract：:The concentration of vitamin E (alpha-tocopherol) was measured in samples of cortex from patients with Alzheimer's disease (AD), fetuses with Down's syndrome (DS), and also in a group of centenarians. The mean tocopherol concentrations in the two patient groups did not differ significantly from appropriate controls. W...

journal_title：Neurochemical research

authors： Metcalfe T,Bowen DM,Muller DP

更新日期：1989-12-01 00:00:00

abstract：:Activities toward arachidonyl-labelled phospholipase A2 substrates were assayed in fractions of white matter and cerebral cortex from control subjects and in fractions of demyelinated plaque, normal-appearing white matter and cerebral cortex from subjects who died with multiple sclerosis. Membranous activity at pH 8.6...

journal_title：Neurochemical research

authors： Huterer SJ,Tourtellotte WW,Wherrett JR

更新日期：1995-11-01 00:00:00

abstract：:The hypothalamic paraventricular nucleus (PVN) is a key site for regulating neuroendocrine functions in the magnocellular part and autonomic activities in the parvocellular part. Its anatomical proximity to the third ventricle could be a good target for intrathecal injection of baclofen. We investigated the correlatio...

journal_title：Neurochemical research

authors： Czell D,Efe T,Preuss M,Schofer MD,Becker R

更新日期：2012-02-01 00:00:00

abstract：:Bovine brain synaptic membranes which were frozen and then extensively washed showed low affinity [3H]muscimol binding. These membranes contained GABA and calmodulin, apparently tightly bound within the membrane fraction. Membranes which were additionally treated with the detergent Triton X-100 showed high affinity [3...

journal_title：Neurochemical research

authors： O'Neill C,Williams DC

更新日期：1988-09-01 00:00:00

abstract：:The kinetics and specificity of taurine and beta-alanine uptake were studied in primary cultures of rat astrocytes under identical experimental conditions. The uptake consisted of nonsaturable penetration and saturable high-affinity transport that was strictly sodium dependent. The cells accumulated taurine more effec...

journal_title：Neurochemical research

authors： Holopainen I,Kontro P

更新日期：1986-02-01 00:00:00

abstract：:Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such...

journal_title：Neurochemical research

authors： Mutsuga N,Gainer H

更新日期：2006-02-01 00:00:00

abstract：:The metabolic effects of ganglioside GM1 were found to be quite different in brain synaptosomes and phagocytic cells. Incubation of rat brain cortex synaptosomes with GM1 was shown to decrease the production of reactive oxygen species induced by Fe2+-H2O2 system and measured by chemiluminometric method in the presence...

journal_title：Neurochemical research

authors： Avrova NF,Zakharova IO,Tyurin VA,Tyurina YY,Gamaley IA,Schepetkin IA

更新日期：2002-08-01 00:00:00

abstract：:The effects of 100microg melatonin injection at postnatal day 5 (PD 5) on the development of the central serotonergic systems in male and female rats were investigated. The contents of serotonin (5-HT) and 5-hydroxy-3-indolacetic acid (5-HIAA) were measured in several extrahypothalamic regions at 3, 10 and 42 weeks of...

journal_title：Neurochemical research

authors： Muneoka K,Ogawa T,Takigawa M

更新日期：2000-06-01 00:00:00

abstract：:The synthetic Liver X receptor (LXR) activator T0901317 has been reported to exert neuroprotective effect in Alzheimer's disease, but the relationship between LXR activation and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) remains uncertain. This study investigated the effect of T0901317 on membrane ...

journal_title：Neurochemical research

authors： Cui W,Sun Y,Wang Z,Xu C,Xu L,Wang F,Chen Z,Peng Y,Li R

更新日期：2011-10-01 00:00:00

abstract：:In the present study mitochondrial respiratory function of fibroblasts from a patient affected by early-onset parkinsonism carrying the homozygous W437X nonsense mutation in the PINK1 gene has been thoroughly characterized. When compared with normal fibroblasts, the patient's fibroblast mitochondria exhibited a lower ...

journal_title：Neurochemical research

authors： Piccoli C,Sardanelli A,Scrima R,Ripoli M,Quarato G,D'Aprile A,Bellomo F,Scacco S,De Michele G,Filla A,Iuso A,Boffoli D,Capitanio N,Papa S

更新日期：2008-12-01 00:00:00

abstract：:Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following inhaled anesthetics treatment can perturb cerebral homeostasis, which may be associated with their induced neurotoxicity. Seven-day-old rat ...

journal_title：Neurochemical research

authors： Liu B,Gu Y,Xiao H,Lei X,Liang W,Zhang J

更新日期：2015-04-01 00:00:00

abstract：:The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively involving the limbic system and especially marked in the hippocampus, makes it useful to obtain in vivo models of neurodegeneration associated with behavioural alterations...

journal_title：Neurochemical research

authors： Corvino V,Marchese E,Michetti F,Geloso MC

更新日期：2013-02-01 00:00:00

abstract：:Nicotinic agonists stimulate 22Na flux in rat pheochromocytoma PC12 cells. The stimulatory effect of carbamylcholine is maximal at 1 mM, while the stimulatory effect of nicotine and anatoxin maximize at the same level at 100 microM and 10 microM, respectively. The tertiary amines arecolone and isoarecolone have no eff...

journal_title：Neurochemical research

authors： Daly JW,Nishizawa Y,Edwards MW,Waters JA,Aronstam RS

更新日期：1991-04-01 00:00:00

abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...

journal_title：Neurochemical research

authors： Rath MF,Rohde K,Klein DC,Møller M

更新日期：2013-06-01 00:00:00

abstract：:A case-control study was undertaken to investigate the status of platelet monoamine oxidase-B (MAO-B) activity in Indian cases of idiopathic Parkinson's disease. A significant increase in the activity of platelet MAO-B was observed in Parkinson's cases (n = 26) as compared to controls (n = 26). No significant change i...

journal_title：Neurochemical research

authors： Husain M,Shukla R,Dikshit M,Maheshwari PK,Nag D,Srimal RC,Seth PK,Khanna VK

更新日期：2009-08-01 00:00:00

abstract：:SENP3 (SUMO-specific proteases 3), a member of the small ubiquitin-like modifier specific protease family, was identified as a molecule that deconjugates SUMOylation of modified protein substrates and functions as an isopeptidase by disrupting SUMO homeostasis to facilitate cancer development and progression. However,...

journal_title：Neurochemical research

authors： Wei H,Teng H,Huan W,Zhang S,Fu H,Chen F,Wang J,Wu C,Zhao J

更新日期：2012-12-01 00:00:00

abstract：:The adaptation of cells to hyperosmotic conditions involves accumulation of organic osmolytes to achieve osmotic equilibrium and maintenance of cell volume. The Na+ and Cl(-)-coupled betaine/GABA transporter, designated BGT-1, is responsible for the cellular accumulation of betaine and has been proposed to play a role...

journal_title：Neurochemical research

authors： Olsen M,Sarup A,Larsson OM,Schousboe A

更新日期：2005-06-01 00:00:00

abstract：:It is an honour to have this opportunity write an article in recognition of the immense contributions of Bruce Ransom to the field of glial research. For me (BAM) personally there are many highlights both as a colleague and a friend that come to mind when I reflect on the many years that I have known Bruce. My own ent...

journal_title：Neurochemical research

authors： MacVicar BA,Choi HB

更新日期：2017-09-01 00:00:00

abstract：:Changes in oxygen consumption, body temperature and energy metabolism were studied while mice were repeatedly exposed to a sealed environment. The average tolerance limits of environmental oxygen level (vol%) and the average oxygen consumption rates (ml/g x min) were exponentially decreased and the average body rectal...

journal_title：Neurochemical research

authors： Lu GW,Cui XY,Zhao BM

更新日期：1999-05-01 00:00:00

abstract：:The 7S NGF complex from the male mouse submaxillary gland consists of the alpha, gamma, and beta subunits in the ratio alpha 2 gamma 2 beta. The beta (NGF) subunit contains all the known biolocial activity of 7S NGF. The alpha and gamma subunits are both members of glandular kallikrein gene family, yet only gamma subu...

journal_title：Neurochemical research

authors： Burcham TS,Sim I,Bolin LM,Shooter EM

更新日期：1991-06-01 00:00:00

abstract：:Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...

journal_title：Neurochemical research

authors： Fagundes AO,Aguiar MR,Aguiar CS,Scaini G,Sachet MU,Bernhardt NM,Rezin GT,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-11-01 00:00:00

abstract：:It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...

journal_title：Neurochemical research

authors： Potapenko E,Kostyuk E,Voitenko N,Kostyuk P

更新日期：2004-09-01 00:00:00

abstract：:Oxidative stress is known to induce cell death in a wide variety of cell types, apparently by modulating intracellular signaling pathways. Activation of extracellular signal-regulated kinase (ERK) in oxidative stress remains controversial. In some cellular systems, the ERK activation is associated with protection agai...

journal_title：Neurochemical research

authors： Lee WC,Choi CH,Cha SH,Oh HL,Kim- YK

更新日期：2005-02-01 00:00:00

abstract：:Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...

journal_title：Neurochemical research

authors： Colwell CS,Ghiani CA

更新日期：2020-03-01 00:00:00

abstract：:We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...

journal_title：Neurochemical research

authors： Luo H,Xu IS,Chen Y,Yang F,Yu L,Li GX,Liu FY,Xing GG,Shi YS,Li T,Han JS,Wan Y

更新日期：2008-10-01 00:00:00

abstract：:Müller cells, the predominant glial cells in the retina, are thought to play important roles in the survival of retinal neurons. Previous studies have demonstrated that Müller cells express brain-derived neurotrophic factor (BDNF), which has a pronounced neurotrophic effect on retinal ganglion cells. In this study, we...

journal_title：Neurochemical research

authors： Seki M,Tanaka T,Sakai Y,Fukuchi T,Abe H,Nawa H,Takei N

更新日期：2005-09-01 00:00:00

abstract：:Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...

journal_title：Neurochemical research

authors： Lin SS,Hung CF,Ho CC,Liu YH,Ho HC,Chung JG

更新日期：2000-11-01 00:00:00

abstract：:A study was undertaken in rats to evaluate the effects of short-term oral ethanol administration on the levels of fatty acid ethyl esters (FAEE) in brain and peripheral organs in the presence and absence of pretreatment with L-carnitine. Administration of ethanol to rats for seven days resulted in fatty acid ethyl est...

journal_title：Neurochemical research

authors： Calabrese V,Rizza V

更新日期：1999-01-01 00:00:00