Effects of L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat.

abstract：:Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activ...

journal_title：Neurochemical research

authors： Chechik T,Poduslo SE

更新日期：1987-01-01 00:00:00

abstract：:Bilateral lesion of the nucleus basalis with ibotenic acid infusions in young and aged rats results in the degeneration of cholinergic neurons which innervate the cortex. As expected, high-affinity uptake of choline was decreased in the frontal cortex subsequent to the lesion. Twenty one days after surgery there was a...

journal_title：Neurochemical research

authors： Gomeza J,Aragón C,Giménez C

更新日期：1992-04-01 00:00:00

abstract：:Protein kinase C (PKC) plays a key role in cellular events including proliferation, survival and differentiation. Our previous study showed the effect of phorbol 12-myristate 13-acetate (PMA), a PKC activator, inducing a decrease in retinal cells proliferation. This effect was mediated by muscarinic type 1 receptors (...

journal_title：Neurochemical research

authors： dos Santos AA,Medina SV,de Araújo Martins L,de Araujo EG

更新日期：2009-05-01 00:00:00

abstract：:Evidence is presented in support of the working hypothesis that "prenervous" neurotransmitters directly participate in cell-cell interactions occurring during the first several cleavage divisions of sea urchin embryos, a function which may occur during the early development of higher animals as well. This intercellula...

journal_title：Neurochemical research

authors： Buznikov GA,Shmukler YB

更新日期：1981-01-01 00:00:00

abstract：:The conversion of phosphoethanolamine to phosphocholine requires 3 separate N-methyltransferases. We had previously purified the enzyme catalyzing the last methylation, phosphodimethylethanolamine N-methyltransferase. We have successfully purified the enzyme catalyzing the initial methylation of phosphoethanolamine. A...

journal_title：Neurochemical research

authors： Mukherjee S,Freysz L,Kanfer JN

更新日期：1995-10-01 00:00:00

abstract：:Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following inhaled anesthetics treatment can perturb cerebral homeostasis, which may be associated with their induced neurotoxicity. Seven-day-old rat ...

journal_title：Neurochemical research

authors： Liu B,Gu Y,Xiao H,Lei X,Liang W,Zhang J

更新日期：2015-04-01 00:00:00

abstract：:It is well known that the principal biomolecules involved in Alzheimer's disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Aβ42). ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggr...

journal_title：Neurochemical research

authors： Méndez-Garrido A,Hernández-Rodríguez M,Zamorano-Ulloa R,Correa-Basurto J,Mendieta-Wejebe JE,Ramírez-Rosales D,Rosales-Hernández MC

更新日期：2014-11-01 00:00:00

abstract：:The calcium-activated phosphodiesteratic hydrolysis of 32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasi...

journal_title：Neurochemical research

authors： Van Rooijen LA,Agranoff BW

更新日期：1985-08-01 00:00:00

abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...

journal_title：Neurochemical research

authors： Villa RF,Marzatico F,Benzi G

更新日期：1983-02-01 00:00:00

abstract：:Mammalian MTH1 protein, a MutT-related protein, catalyzes the hydrolysis of 8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) to monophosphate, thereby preventing incorporation of 8-oxo-7,8-dihydroguanine (8-oxoguanine) into RNA. In this study, we applied immunohistochemistry to follow the expression of MTH1 and the ...

journal_title：Neurochemical research

authors： Song XN,Zhang LQ,Liu DG,Lin J,Zheng JD,Dai DP,Hei AL,Hayakawa H,Sekiguchi M,Cai JP

更新日期：2011-08-01 00:00:00

abstract：:Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...

journal_title：Neurochemical research

authors： Wang XP,Ye P,Lv J,Zhou L,Qian ZY,Huang YJ,Mu ZH,Wang X,Liu XJ,Wan Q,Yang ZH,Wang F,Zou YY

更新日期：2019-04-01 00:00:00

abstract：:To study the early effects of neonatal 5,7-dihydroxytryptamine lesions on 5-hydroxytryptamine1A (5-HT1A) receptors, we measured regional [3H]8-OH-DPAT-labeled 5-HT1A sites in binding assays and compared them to our previous studies of [3H]paroxetine-labeled 5-HT transporter sites during the first month in the same rat...

journal_title：Neurochemical research

authors： Pranzatelli MR

更新日期：1994-03-01 00:00:00

abstract：:We have previously shown that peptide neurotensin inhibits cerebral cortex synaptosomal membrane Na+, K+-ATPase, an effect fully prevented by blockade of neurotensin NT1 receptor by antagonist SR 48692. The work was extended to analyze neurotensin effect on Na+, K+-ATPase activity present in other synaptosomal membran...

journal_title：Neurochemical research

authors： López Ordieres MG,Rodríguez de Lores Arnaiz G

更新日期：2002-11-01 00:00:00

abstract：:Excessive hyperbilirubinemia can cause irreversible neurological damage in the neonatal period. However, the complete understanding of the pathogenesis of unconjugated bilirubin (UCB) encephalopathy remains a matter of debate. This study investigates whether UCB inhibits the endocytosis of cationized ferritin (CF) by ...

journal_title：Neurochemical research

authors： Silva RF,Mata LM,Gulbenkian S,Brites D

更新日期：2001-07-01 00:00:00

abstract：:The metabolic effects of ganglioside GM1 were found to be quite different in brain synaptosomes and phagocytic cells. Incubation of rat brain cortex synaptosomes with GM1 was shown to decrease the production of reactive oxygen species induced by Fe2+-H2O2 system and measured by chemiluminometric method in the presence...

journal_title：Neurochemical research

authors： Avrova NF,Zakharova IO,Tyurin VA,Tyurina YY,Gamaley IA,Schepetkin IA

更新日期：2002-08-01 00:00:00

abstract：:The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...

journal_title：Neurochemical research

authors： Kandasamy M,Radhakrishnan RK,Poornimai Abirami GP,Roshan SA,Yesudhas A,Balamuthu K,Prahalathan C,Shanmugaapriya S,Moorthy A,Essa MM,Anusuyadevi M

更新日期：2019-08-01 00:00:00

abstract：:The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a common precursor, prosaposin. Saposins share several structural properties, including six similarly located cysteines forming three disulfide bridges with the s...

journal_title：Neurochemical research

authors： Vaccaro AM,Salvioli R,Tatti M,Ciaffoni F

更新日期：1999-02-01 00:00:00

abstract：:The volume-regulated anion channel, VRAC, plays an important role in cell volume regulation. This channel is permeable for a wide variety of anions, amino acids, and organic osmolytes, including taurine. However, nothing is known about possible water permeability of this channel. Water permeability of endothelial cell...

journal_title：Neurochemical research

authors： Nilius B

更新日期：2004-01-01 00:00:00

abstract：:The activation of caspase-3 is considered to be a reliable marker for apoptotic cell death, and a 120-kDa fragment of αII-spectrin is generated by caspase-3 mediated cleavage of this structural protein. In the present study, we compared cleaved αII-spectrin (120-kDa) and cleaved caspase-3-immunoreactive cells and thei...

journal_title：Neurochemical research

authors： Hwang IK,Ahn JH,Yoo DY,Lee CH,Yoo KY,Choi JH,Moon SM,Shin HC,Won MH

更新日期：2012-03-01 00:00:00

abstract：:Several models for the transmission and progression of prion diseases have arisen, evolving with the acquisition of new experimental results. It is generally accepted that the PrP(Sc) protein is at least part of the infectious particle and the major protein component of the scrapie-associated fibrils (SAFs) that chara...

journal_title：Neurochemical research

authors： Grossman A,Zeiler B,Sapirstein V

更新日期：2003-06-01 00:00:00

abstract：:Endogenous phosphorylation of proteins from rat brain synaptosomal plasma membranes was studied in vitro. Cyclic AMP (cAMP) markedly stimulated(32)P incorporation in three protein bands with molecular weights of 75,000, 57,000, and 54,000, respectively. The effect of the behaviorally active peptide ACTH1-24 on this en...

journal_title：Neurochemical research

authors： Zwiers H,Veldhuis HD,Schotman P,Gispen WH

更新日期：1976-12-01 00:00:00

abstract：:The pathophysiological mechanism(s) underlying Alzheimer's disease (AD) still remain unclear, and no disease-modifying or prophylactic therapies are currently available. Unraveling the fundamental neuropathogenesis of AD is an important challenge. Several studies on AD have suggested lesions in a number of CNS areas i...

journal_title：Neurochemical research

authors： Daulatzai MA

更新日期：2012-04-01 00:00:00

abstract：:The presynaptic dopamine (DA) D2 receptor-mediated regulation of ATP-sensitive potassium (K+ATP) channels was examined in slices of the rat caudate-putamen. When slices were incubated with the specific D2 receptor antagonist (-)-sulpiride (SLP), a concentration-dependent increase of extracellular DA release was observ...

journal_title：Neurochemical research

authors： Neusch C,Runde D,Moser A

更新日期：2000-12-01 00:00:00

abstract：:The frontal cortex, hippocampus, and cerebellum of the Fischer 344 rat were examined for an age-dependent change in neuronal and non-neuronal binding. Clonazepam and Ro5-6669 displaceable [3H]diazepam binding were used as indicators of [3H]diazepam binding on neuronal and non-neuronal membranes, respectively. In both ...

journal_title：Neurochemical research

authors： Komiskey HL,MacFarlan MF

更新日期：1983-09-01 00:00:00

abstract：:Convection enhanced delivery of 6-hydroxydopamine (6-OHDA) to the rat striatum results in a model of Parkinson's disease. An important feature of this unilateral model is the progressive loss of dopaminergic (DA) neurons over the course of several weeks. To improve the understanding of this model, gene expression chan...

journal_title：Neurochemical research

authors： Na SJ,DiLella AG,Lis EV,Jones K,Levine DM,Stone DJ,Hess JF

更新日期：2010-05-01 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is a neurovisceral disorder characterized by lysosomal sequestration of endocytosed LDL-cholesterol, premature and abnormal enrichment of cholesterol in trans Golgi cisternae and accompanying anomalies in intracellular sterol trafficking. In addition to cholesterol, the NPC lesion has...

journal_title：Neurochemical research

authors： Vanier MT

更新日期：1999-04-01 00:00:00

abstract：:The release of labeled norepinephrine from preloaded synaptosomes requires the presence of potassium and calcium. ATP-dependent binding of calcium to synaptic plasma membranes (SPM) may provide a means of maintaining the cation in a readily available pool for the triggering of transmitter release. A high Ca-binding ca...

journal_title：Neurochemical research

authors： Corpus V,Sun AY

更新日期：1983-04-01 00:00:00

abstract：:Spinal cord injury (SCI) is a type of long-term disability with a high morbidity rate in clinical settings for which there is no effective clinical treatment to date. Usually, lithium is used as a popular mood stabilizer. Recently, growing evidence has shown that lithium has clear neuroprotective effects after SCI, an...

journal_title：Neurochemical research

authors： Li B,Ren J,Yang L,Li X,Sun G,Xia M

更新日期：2018-04-01 00:00:00

abstract：:To evaluate the influence of light and darkness on brain pyroglutamyl-peptidase I (pGluPI) activity, four experimental groups of rats were compared at the same time-point (10.00 h). Two groups were designed with a standard 12-12 h light-dark cycle: In group A, the lights were on from 7.00 h to 19.00 h, and the experim...

journal_title：Neurochemical research

authors： Ramírez M,Arechaga G,Martínez JM,Prieto I,Ramírez-Expósito MJ,Sánchez B,Alba F

更新日期：2001-05-01 00:00:00

abstract：:We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...

journal_title：Neurochemical research

authors： Simzar S,Ellyin R,Shau H,Sarafian TA

更新日期：2000-12-01 00:00:00