Inhibition of brain and liver 3-hydroxy-3-methylglutaryl-CoA reductase and mevalonate-5-pyrophosphate decarboxylase in experimental hyperphenylalaninemia.

abstract：:The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...

journal_title：Neurochemical research

authors： Xie J,Han F,Shi Y

更新日期：2014-04-01 00:00:00

abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...

journal_title：Neurochemical research

authors： Schousboe A,Larsson OM,Seiler N

更新日期：1986-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative disease that leads to progressive paralysis and inevitable death 3-5 years after diagnosis. The mechanisms underlying this process remain unknown, but new evidence indicates that accumulating levels of D-serine result from the downre...

journal_title：Neurochemical research

authors： Wang W,Duan W,Wang Y,Wen D,Liu Y,Li Z,Hu H,Cui H,Cui C,Lin H,Li C

更新日期：2017-04-01 00:00:00

abstract：:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) an...

journal_title：Neurochemical research

authors： Hermann A,Varga V,Janáky R,Dohovics R,Saransaari P,Oja SS

更新日期：2000-08-01 00:00:00

abstract：:The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...

journal_title：Neurochemical research

authors： Kandasamy M,Radhakrishnan RK,Poornimai Abirami GP,Roshan SA,Yesudhas A,Balamuthu K,Prahalathan C,Shanmugaapriya S,Moorthy A,Essa MM,Anusuyadevi M

更新日期：2019-08-01 00:00:00

abstract：:Rats were long-term morphine-intoxicated by a fluid-diet model ensuring an equal nutrient intake in morphinized and control rats. Uptake of neurotransmitters and D-ala2-met5-enkephalinamide (Enk) was studied in the particulate fractions (obtained at 10,000 g) from well defined brain regions of long-term intoxicated an...

journal_title：Neurochemical research

authors： Rönnbäck L,Hansson E,Cupello A,Rapallino MV,Zeuchner J,Rosengren L

更新日期：1986-02-01 00:00:00

abstract：:Activation of cholinergic muscarinic receptors results in an increased turnover of membrane inositol phospholipids. In rat cerebral cortex slices, carbachol- and acetylcholine-induced inositol phosphates ([3H]InsPs) accumulation is maximal in 7 day-old rats and lowest in adults, while the density of muscarinic binding...

journal_title：Neurochemical research

authors： Balduini W,Costa LG,Murphy SD

更新日期：1990-01-01 00:00:00

abstract：:BCL-2-associated athanogene-1(BAG-1) is a multifunctional and anti-apoptotic protein that was first identified as a binding partner of BCL-2. But the effects and mechanisms for BAG-1 against hypoxic damage is unclear up to now. Whether BAG-1 could protect the human brain against hypoxic damage through up-regulating 70...

journal_title：Neurochemical research

authors： Wang Y,Jia C,Li QS,Xie CY,Zhang N,Qu Y

更新日期：2017-10-01 00:00:00

abstract：:The effects of mu, delta, and kappa receptor-agonists on forskolin stimulated cyclic adenosine-3',5'-monophosphate (cAMP) formation were examined in astroglial enriched primary cultures from the cerebral cortex of newborn rats. Intracellular cAMP accumulation was quantified by radioimmunoassay. Morphine was used as a ...

journal_title：Neurochemical research

authors： Eriksson PS,Hansson E,Rönnbäck L

更新日期：1990-11-01 00:00:00

abstract：:The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high levels of Glu at synapses during aging, we used transgenic (Tg) mice that over-express the enzyme ...

journal_title：Neurochemical research

authors： Choi IY,Lee P,Wang WT,Hui D,Wang X,Brooks WM,Michaelis EK

更新日期：2014-01-01 00:00:00

abstract：:Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specif...

journal_title：Neurochemical research

authors： Freysz L,Farooqui AA,Horrocks LA,Massarelli R,Dreyfus H

更新日期：1991-11-01 00:00:00

abstract：:Metformin is the most frequently used drug for the treatment of type 2 diabetes in humans. However, only little is known about effects of metformin on brain metabolism. To investigate potential metabolic consequences of an exposure of brain cells to metformin, we incubated rat astrocyte-rich primary cultures with this...

journal_title：Neurochemical research

authors： Westhaus A,Blumrich EM,Dringen R

更新日期：2017-01-01 00:00:00

abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...

journal_title：Neurochemical research

authors： Hartley DM,Snodgrass SR

更新日期：1990-07-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) and Schwann cells (SCs) are closely-related cell types with regeneration-promoting properties. Comparative gene expression analysis is particularly relevant since it may explain cell type-specific effects and guide the use of each cell type into special clinical applications. In the ...

journal_title：Neurochemical research

authors： Omar M,Hansmann F,Kreutzer R,Kreutzer M,Brandes G,Wewetzer K

更新日期：2013-05-01 00:00:00

abstract：:Sleep disorders negatively affect cognition and health. Recent evidence has indicated that chromatin remodeling via histone acetylation regulates cognitive function. This study aimed to investigate the possible roles of histone acetylation in sleep deprivation (SD)-induced cognitive impairment. Results of the Morris w...

journal_title：Neurochemical research

authors： Duan R,Liu X,Wang T,Wu L,Gao X,Zhang Z

更新日期：2016-09-01 00:00:00

abstract：:A sensitive and rapid assay method method for cysteic acid decarboxylase was develped which combined the selectivity of ion exchange resin (a complete retention of the substrate, cysteic acid, and exclusion of the product, taurine) with the speed of a vacuum filtration. The synthesis and purification of 35S-labeled cy...

journal_title：Neurochemical research

authors： Wu JY,Moss LG,Chen MS

更新日期：1979-04-01 00:00:00

abstract：:The axonal transport of tRNA has been investigated in the chick optic system. Chicks were injected with [3H]uridine intraocularly or intracranially and the RNA of the retina, nerve complex, and tecta separated by polyacrylamide gel electrophoresis and then counted. The ratio of tRNA to rRNA specific activities increas...

journal_title：Neurochemical research

authors： Por S,Gunning PW,Jeffrey PL,Austin L

更新日期：1978-08-01 00:00:00

abstract：:The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and -amino butyric acid (GABA) and expression of glial fibrillary acid protein (GFAP), vascular endothe...

journal_title：Neurochemical research

authors： Zeng K,Xu H,Mi M,Zhang Q,Zhang Y,Chen K,Chen F,Zhu J,Yu X

更新日期：2009-02-01 00:00:00

abstract：:Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children, with hyperoxia (HHI) treatment being a clinical therapy for newborn resuscitation. Although cerebral edema is a common outcome after HI, the mechanisms leading to excessive fluid accumu...

journal_title：Neurochemical research

authors： Ferrari DC,Nesic O,Perez-Polo JR

更新日期：2010-12-01 00:00:00

abstract：UNLABELLED:Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive...

journal_title：Neurochemical research

authors： Talarowska M,Gałecki P,Maes M,Bobińska K,Kowalczyk E

更新日期：2012-08-01 00:00:00

abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...

journal_title：Neurochemical research

authors： Bates DJ,Sirkos S,Moses EK,Austin L

更新日期：1983-03-01 00:00:00

abstract：:We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...

journal_title：Neurochemical research

authors： Yoshida M,Colma DR

更新日期：2001-06-01 00:00:00

abstract：:The current studies focus on what mechanisms regulate the concentration of PLP mRNA in cells. The PLP mRNA is very stable and these studies suggest that its stability is regulated by a trans-acting factor specific to oligodendrocytes. In order to test whether the 3'untranslated region (3'UTR) of the PLP mRNA might reg...

journal_title：Neurochemical research

authors： Mallon BS,Macklin WB

更新日期：2002-11-01 00:00:00

abstract：:Acidosis (pH 6.0) led to significant decrease in high-affinity choline uptake by rat brain synaptosomes. The effects persisted following pH readjustment (7.4) of the incubation medium, consisting of decrease in both Km and Vmax of the affinity system. pH readjustment coincided with synaptosomal leakage of lactate dehy...

journal_title：Neurochemical research

authors： Cancela JM,Beley A

更新日期：1995-07-01 00:00:00

abstract：:This study aimed at comparing the binding characteristics of [3H]ketanserin, a high-affinity serotonin 2A (5-HT2A) receptor antagonist, in the prefrontal cortex, hippocampus and striatum of human brain post-mortem. The results indicated the presence of a single population of binding sites in all the regions investigat...

journal_title：Neurochemical research

authors： Marazziti D,Rossi A,Palego L,Giannaccini G,Naccarato A,Lucacchini A,Cassano GB

更新日期：1997-06-01 00:00:00

abstract：:Direct evidence for the excitotoxicity of 3-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), the Lathyrus sativus neurotoxin has been studied by examining the binding of chemically synthesized [2,3 3H]ODAP ([3H]ODAP) to synaptic membranes. [3H]ODAP binding to membranes was mostly nonspecific, with only a very low s...

journal_title：Neurochemical research

authors： Jain RK,Junaid MA,Rao SL

更新日期：1998-09-01 00:00:00

abstract：:To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...

journal_title：Neurochemical research

authors： Tanaka K,Asanuma M,Ogawa N

更新日期：2004-08-01 00:00:00

abstract：:One pathway by which tryptophan is metabolized in the brain as well as in the periphery is through cleavage of the indole ring to formylkynurenine and then kynurenine. Indoleamine-2,3-dioxygenase, the enzyme that catalyzes this cleavage, and kynurenine are distributed all across the different anatomic regions of brain...

journal_title：Neurochemical research

authors： Gál EM,Sherman AD

更新日期：1980-03-01 00:00:00

abstract：:We review here the possible mechanisms of neuronal degeneration caused by L-cysteine, an odd excitotoxin. L-Cysteine lacks the omega carboxyl group required for excitotoxic actions via excitatory amino acid receptors, yet it evokes N-methyl-D-aspartate (NMDA) -like excitotoxic neuronal death and potentiates the Ca2+ i...

journal_title：Neurochemical research

authors： Janáky R,Varga V,Hermann A,Saransaari P,Oja SS

更新日期：2000-10-01 00:00:00

abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...

journal_title：Neurochemical research

authors： Villa RF,Marzatico F,Benzi G

更新日期：1983-02-01 00:00:00