Abstract:
:Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specific activity before that of monoacylglycerol lipase. The increase was observed only up to 24 hours and no differences between diacylglycerol lipase activity of control and ganglioside treated cells were observed after 48 hours. The data indicate that the treatment of neurons with exogenous gangliosides affect the diglyceride metabolism in stimulating not only the enzymes catalyzing their production but also those involved in their catabolism.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Freysz L,Farooqui AA,Horrocks LA,Massarelli R,Dreyfus Hdoi
10.1007/BF00966702subject
Has Abstractpub_date
1991-11-01 00:00:00pages
1241-4issue
11eissn
0364-3190issn
1573-6903journal_volume
16pub_type
杂志文章abstract::An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965726
更新日期:1983-03-01 00:00:00
abstract::Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2430-6
更新日期:2018-02-01 00:00:00
abstract::The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) ...
journal_title:Neurochemical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1023/b:nere.0000026402.09466.54
更新日期:2004-07-01 00:00:00
abstract::The NG 108-15 (neuroblastoma X glioma hybrid) cell line was used as an in vitro neuronal model to evaluate potential antagonists of the Na+-selective carboxylic ionophore monensin. Changes in membrane electrical characteristics induced by monensin with and without the simultaneous administration of antagonists were me...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007548307554
更新日期:2000-07-01 00:00:00
abstract::The mutual interactions and the effects of GABA on the saturable transport components of taurine and hypotaurine were investigated with mouse brain slices. The low-affinity taurine transport was competitively inhibited by both hypotaurine and GABA. Hypotaurine did not alter the kinetic parameters of high-affinity taur...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964995
更新日期:1983-11-01 00:00:00
abstract::In order to develop a simplified method for long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density (10(3) cells/cm(2)), we optimized and modified conventional culturing methods. The modifications of our simplified method include: (1) combinational application of two growth substrates...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0189-0
更新日期:2010-09-01 00:00:00
abstract::There is increasing evidence to suggest that hepatic encephalopathy in acute liver failure is the result of altered glutamatergic function. In particular, the high affinity uptake of glutamate is decreased in brain slices and synaptosomes from rats with acute liver failure as well as by exposure of cultured astrocytes...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022532623281
更新日期:1999-11-01 00:00:00
abstract::S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9915-x
更新日期:2009-08-01 00:00:00
abstract::Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei iso...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965136
更新日期:1982-08-01 00:00:00
abstract::Pathogens such as bacterial lipopolysaccharide (LPS) play an important role in promoting the production of the inflammatory cytokines interleukin-1 beta (IL-1β) and tumour necrosis factor-α (TNF-α) in response to infection or damage in microglia. However, whether different signalling pathways regulate these two inflam...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02895-1
更新日期:2019-12-01 00:00:00
abstract::The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacrylamide gel electrophoresis and computerized quantitation. Experiments were done on three groups of eggs: control group was incubated in the dark; simultan...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00993240
更新日期:1987-04-01 00:00:00
abstract::Cationic lipid formulations consisting of 3beta [N-(N', N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and the helper lipid dioleoylphosphatidylethanolamine (DOPE) (1.5: 1 molar ratio) were prepared by solvent evaporation and sized by high pressure extrusion. Liposomes made of 1:1 molar ratio 1 ,2-dioleoyl-3...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021012727796
更新日期:1999-05-01 00:00:00
abstract::Spinal cord injury (SCI) is a functional impairment of the spinal cord caused by external forces, accompanied by limb movement disorders and permanent paralysis, which seriously lowers the life quality of SCI patients. Secondary injury caused by inflammation attenuated the therapeutic effects of SCI. Therefore, the ex...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03211-y
更新日期:2021-01-13 00:00:00
abstract::Populations of enriched glial precursor cells and astrocytes isolated from primary cultures of newborn rat brain were used to study the synthesis of sulfated glycoproteins. Both cell types incorporated [3H]glucosamine and [35S]sulfate into carbohydrate side chains of proteoglycans and glycoproteins. The rate of incorp...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965947
更新日期:1986-08-01 00:00:00
abstract::Caspase activation and apoptotic events may take place in terminal regions far removed from the cell body and contribute to synapse loss in neurodegenerative diseases. For examination of events in terminals, we have developed a cell-free assay using quantitative flow cytometric analysis (fluorescence-activated cell so...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1019840417796
更新日期:2002-06-01 00:00:00
abstract::Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1399-7
更新日期:2014-11-01 00:00:00
abstract::Single prolonged stress (SPS) is one of the preclinical models of posttraumatic stress disorder (PTSD) in humans. Not every traumatized person develops PTSD and the onset of the disease varies from months to many years after exposure to life-threatening events. The pathogenetic neurometabolites in PTSD have not been i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2232-x
更新日期:2017-08-01 00:00:00
abstract::The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9763-0
更新日期:2009-02-01 00:00:00
abstract::Tyrosine hydroxylase (TH) activity and levels of tyrosine were measured in whole brains from mice subjected to brief electric foot shock or to single or multiple injections of hydrocortisone acetate (HCA; 20 mg/kg). Adult brain tyrosine levels showed a rapid increase after either foot shock or a single injection of HC...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964094
更新日期:1977-04-01 00:00:00
abstract::The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969632
更新日期:1989-02-01 00:00:00
abstract::Glutamine synthetase (GS) is the major glutamine-forming enzyme of vertebrates and is accepted to be a marker of astroglial cells. Maturation of astroglial cells is characterized by an increase of GS activity, and the regulation of this enzyme is the topic of many publications. Because of the fundamental role of the G...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-2754-5
更新日期:2005-05-01 00:00:00
abstract::(4S)-4-Amino-5,6-heptadienoic acid [S)-gamma-allenyl-GABA; MDL 72483) is a potent inactivator of brain GABA-T in mice; (ED50 (i.p.) = 60 mg.kg-1; ED50 (oral) = 70 mg.kg-1). Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concent...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966092
更新日期:1991-03-01 00:00:00
abstract::Cell densities and respiratory rates of astrocytes from neonatal rat brain grown in primary culture were determined after 20-30 days in vitro. Cells grown in flasks reached lower densities (microgram DNA/cm2) and higher protein:DNA ratios than cells grown in petri dishes. Respiratory rates were lower for cells grown i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964355
更新日期:1981-12-01 00:00:00
abstract::Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of gli...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2626-4
更新日期:2018-11-01 00:00:00
abstract::The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02833-1
更新日期:2019-08-01 00:00:00
abstract::Exposure to sevoflurane and other inhalational anesthetics can induce cognitive impairment in elderly patients. Studies have indicated that methylene blue (MB) has beneficial effects on multiple neurodegenerative diseases and the mechanism involves mitochondrial function preservation. However, whether MB can attenuate...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-02976-6
更新日期:2020-04-01 00:00:00
abstract:UNLABELLED:Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B pr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9365-2
更新日期:2007-09-01 00:00:00
abstract::The purpose of this study was to investigate whether the kappa-opioid receptor (KOR) agonist, BRL52537, has a neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury in rats and further explore the underlying mechanisms. Adult male Sprague-Dawley rats were randomly assigned into sham (group A), I/R (...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1139-4
更新日期:2013-11-01 00:00:00
abstract::The effect of anticonvulsant drugs was examined on brain GABA levels and GAD and GABA-T activities. The level of GABA was increased by the treatment with diphenylhydantoin. The drug had no effect on GABA-T activity, whereas GAD activity was inhibited. Carbamazepine increased the GABA level but did not effect GAD and G...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964170
更新日期:1984-02-01 00:00:00
abstract::It is well known that antioxidants containing sulfhydryl (-SH) groups are protective against the toxic effects of mercury. The current study was designed to elucidate the mechanism(s) of the cytoprotective effects of glutathione (GSH) and N-acetylcysteine (NAC) against the toxicity of inorganic mercury (HgCl(2)) in ne...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9962-3
更新日期:2009-09-01 00:00:00