Eclalbasaponin II Ameliorates the Cognitive Impairment Induced by Cholinergic Blockade in Mice.

abstract：:Hypoxia is one of the major common components of vascular risk factors for pathogenesis of Alzheimer's disease. This study investigated the possible relationship between hypoxia and alternative splicing of the excitatory amino acid transporter 2 (EAAT2) in a transgenic model for Alzheimer's disease. We used an APP23 m...

journal_title：Neurochemical research

authors： Münch C,Zhu BG,Mink A,Seefried U,Riepe MW,Ludolph AC,Meyer T

更新日期：2008-06-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...

journal_title：Neurochemical research

authors： Li S,Wang D,Tian Y,Wei H,Zhou Z,Liu L,Wang D,Dong JF,Jiang R,Zhang J

更新日期：2015-07-01 00:00:00

abstract：:Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...

journal_title：Neurochemical research

authors： Wang XP,Ye P,Lv J,Zhou L,Qian ZY,Huang YJ,Mu ZH,Wang X,Liu XJ,Wan Q,Yang ZH,Wang F,Zou YY

更新日期：2019-04-01 00:00:00

abstract：:The K-stimulated release of [3H]ACh from rat midbrain slices prelabeled by incubation with [3H]choline was dependent on extracellular Ca. Phenobarbital inhibited the K-stimulated [3H]ACh release and the IC50 was equal to that found for K-stimulated endogenous ACh release. These results support the suggestion that barb...

journal_title：Neurochemical research

authors： Richter JA,Jackson SK

更新日期：1980-07-01 00:00:00

abstract：:3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington's disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. (1)H NMR spectroscopy was used to ch...

journal_title：Neurochemical research

authors： Tsang TM,Haselden JN,Holmes E

更新日期：2009-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterized by presence of senile plaques in the hippocampus, which are composed mainly of extracellular deposition of a polypeptide known as the beta amyloid, the Aβ. It has been demonstrated on numerous occasions that it was the deposition and aggregation of this Aβ pepti...

journal_title：Neurochemical research

authors： Yang HQ,Li X,Yang WM,Feng SM,Ma JJ

更新日期：2012-10-01 00:00:00

abstract：:Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphat...

journal_title：Neurochemical research

authors： Jacobs TQ,Passarello B,Horwitz J

更新日期：1998-08-01 00:00:00

abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...

journal_title：Neurochemical research

authors： Michaelis ML,Michaelis EK,Simpson AE

更新日期：1982-02-01 00:00:00

abstract：:The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603 +/- 6 to 22 +/- 2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but d...

journal_title：Neurochemical research

authors： Hirsch JA,Gibson GE

更新日期：1984-08-01 00:00:00

abstract：:Single exposure of adult male rats to low environmental temperature (LET, 12 +/- 0.5 degrees C) for 2 h significantly increased the hypothalamic and striatal GABA levels without affecting those in other regions of brain. The activity of glutamate decarboxylase (GAD) was elevated in hypothalamus (H) and corpus striatum...

journal_title：Neurochemical research

authors： Biswas S,Poddar MK

更新日期：1990-08-01 00:00:00

abstract：:The control and maintenance of the intracellular redox state is an essential task for cells and organisms. NAD(+) and NADH constitute a redox pair crucially involved in cellular metabolism as a cofactor for many dehydrogenases. In addition, NAD(+) is used as a substrate independent of its redox-carrier function by enz...

journal_title：Neurochemical research

authors： Wilhelm F,Hirrlinger J

更新日期：2012-11-01 00:00:00

abstract：:Hypoxia-induced oxidative stress is one of the major hallmark reasons underlying brain dysfunction. In the present manuscript, we have used CoCl2-induced hypoxic mice to investigate alterations in the activities of chief antioxidative stress enzymes- superoxide dismutase (SOD) and catalase (CAT) and expression of thei...

journal_title：Neurochemical research

authors： Rani A,Prasad S

更新日期：2014-09-01 00:00:00

abstract：:The pathophysiological mechanism(s) underlying Alzheimer's disease (AD) still remain unclear, and no disease-modifying or prophylactic therapies are currently available. Unraveling the fundamental neuropathogenesis of AD is an important challenge. Several studies on AD have suggested lesions in a number of CNS areas i...

journal_title：Neurochemical research

authors： Daulatzai MA

更新日期：2012-04-01 00:00:00

abstract：:The goal of this study was to examine the responsiveness of an immortalized catecholaminergic neuronal line, 2N27, to various growth factors and identify those which promote catecholaminergic expression. 2N27 is a newly established neural cell line derived from fetal rat mesencephalic tissue and, thus, contains tyrosi...

journal_title：Neurochemical research

authors： Grove J,Kentroti S,Prasad K,Vernadakis A

更新日期：1997-03-01 00:00:00

abstract：:It is well known that antioxidants containing sulfhydryl (-SH) groups are protective against the toxic effects of mercury. The current study was designed to elucidate the mechanism(s) of the cytoprotective effects of glutathione (GSH) and N-acetylcysteine (NAC) against the toxicity of inorganic mercury (HgCl(2)) in ne...

journal_title：Neurochemical research

authors： Becker A,Soliman KF

更新日期：2009-09-01 00:00:00

abstract：:Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alc...

journal_title：Neurochemical research

authors： Priyanka SH,Syam Das S,Thushara AJ,Rauf AA,Indira M

更新日期：2018-09-01 00:00:00

abstract：:The synthetic Liver X receptor (LXR) activator T0901317 has been reported to exert neuroprotective effect in Alzheimer's disease, but the relationship between LXR activation and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) remains uncertain. This study investigated the effect of T0901317 on membrane ...

journal_title：Neurochemical research

authors： Cui W,Sun Y,Wang Z,Xu C,Xu L,Wang F,Chen Z,Peng Y,Li R

更新日期：2011-10-01 00:00:00

abstract：:Brief limb ischemia was reported to protect neurons against injury induced by subsequent cerebral ischemia-reperfusion, and this phenomenon is known as limb ischemic preconditioning (LIP). To explore the role of nitric oxide (NO) in neuroprotection of LIP in rats, we observed changes in the content of nitric oxide (NO...

journal_title：Neurochemical research

authors： Zhao HG,Sun XC,Xian XH,Li WB,Zhang M,Li QJ

更新日期：2007-11-01 00:00:00

abstract：:The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and -amino butyric acid (GABA) and expression of glial fibrillary acid protein (GFAP), vascular endothe...

journal_title：Neurochemical research

authors： Zeng K,Xu H,Mi M,Zhang Q,Zhang Y,Chen K,Chen F,Zhu J,Yu X

更新日期：2009-02-01 00:00:00

abstract：:The volume-regulated anion channel, VRAC, plays an important role in cell volume regulation. This channel is permeable for a wide variety of anions, amino acids, and organic osmolytes, including taurine. However, nothing is known about possible water permeability of this channel. Water permeability of endothelial cell...

journal_title：Neurochemical research

authors： Nilius B

更新日期：2004-01-01 00:00:00

abstract：:This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...

journal_title：Neurochemical research

authors： da Silva DS,Soares MSP,Martini F,Pesarico AP,de Mattos BDS,de Souza AA,da Silva CEH,Scaini JLR,Machado KDS,Wayne Nogueira C,Spanevello RM,Cunico W

更新日期：2020-02-01 00:00:00

abstract：:Under some pathological conditions in brain, a large amount of superoxide anion (O(2)(-)) is produced, causing various cellular damages. Among three isozymes of superoxide dismutase (SOD), extracellular (EC)-SOD should play a role to detoxify O(2)(-) in extracellular space; however, a little is known about EC-SOD in b...

journal_title：Neurochemical research

authors： Takano K,Tanaka N,Kawabe K,Moriyama M,Nakamura Y

更新日期：2013-01-01 00:00:00

abstract：:Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous entity to a destructive one. The amino acid D-serine over the last 25 years has "shape-shifted" into several identities: a purported glial transmitter activating N-...

journal_title：Neurochemical research

authors： Coyle JT,Balu D,Wolosker H

更新日期：2020-06-01 00:00:00

abstract：:Adaptive changes in serotonergic 5HT1 receptor signalling are believed to underlie the therapeutic effectiveness of antidepressant drugs. Since cells are continuously exposed to neurotransmitters/neuromodulators, spatially and temporally integrated, the responsiveness of a receptor system is dependent upon the physio-...

journal_title：Neurochemical research

authors： Trincavelli ML,Cuboni S,Montali M,Santaguida S,Lucacchini A,Martini C

更新日期：2008-07-01 00:00:00

abstract：:The objective of the present study was to investigate the effects of preincubation of hippocampus homogenates in the presence of homocysteine or methionine on Na+, K+-ATPase and Mg2+-ATPase activities in synaptic membranes of rats. Homocysteine significantly inhibited Na+, K+-ATPase activity, whereas methionine had no...

journal_title：Neurochemical research

authors： Streck EL,Zugno AI,Tagliari B,Franzon R,Wannmacher CM,Wajner M,Wyse AT

更新日期：2001-11-01 00:00:00

abstract：:Exposure to Hg2+ below 10 micrometer destroys synaptosomal membrane-associated sialidase of bovine brain in situ. Inhibition by Cu2+ occurs only at relatively higher concentrations, and is demonstrable after the synaptosomal membrane preparation has been presaturated with Cu2+ . Pb2+ does not inhibit enzymatic activit...

journal_title：Neurochemical research

authors： Yohe HC,Rosenberg A

更新日期：1978-02-01 00:00:00

abstract：:It has been proposed that taurine may function as an oxidant in a dose-dependent manner in vivo and in vitro. The present study was carried out to investigate the relationship between taurine concentration and 3-nitrotyrosine level, a stable marker of peroxynitrite action, in hepatocytes of guinea pig in endotoxemia b...

journal_title：Neurochemical research

authors： Erdamar H,Türközkan N,Balabanli B,Ozan G,Bircan FS

更新日期：2007-11-01 00:00:00

abstract：:The cellular effects of eleven compounds including chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives were studied in rat pheochromocytoma PC12 cells. Of the compounds tested, 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone (A2) significantly increased the levels of the phosph...

journal_title：Neurochemical research

authors： Nishina A,Kimura H,Tsukagoshi H,Kozawa K,Koketsu M,Ninomiya M,Sato D,Obara Y,Furukawa S

更新日期：2013-11-01 00:00:00

abstract：:Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) receptors. There are eight known mGlu receptor subtypes (mGlu1-8), which are widely expressed throughout the brain, and are divided into three group...

journal_title：Neurochemical research

authors： Mercier MS,Lodge D

更新日期：2014-10-01 00:00:00

abstract：:Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...

journal_title：Neurochemical research

authors： Spector R,Boose B

更新日期：1983-08-01 00:00:00