Abstract:
:The K-stimulated release of [3H]ACh from rat midbrain slices prelabeled by incubation with [3H]choline was dependent on extracellular Ca. Phenobarbital inhibited the K-stimulated [3H]ACh release and the IC50 was equal to that found for K-stimulated endogenous ACh release. These results support the suggestion that barbiturates primarily inhibit the Ca-dependent stimulated release of ACh and affect ACh synthesis only indirectly. K-Stimulated release of [3H]5-HT was also inhibited by removing Ca from the medium or by adding phenobarbital which further supports the effects of barbiturates on the depolarization-induced release process. Fluoxetine, an inhibitor of 5-HT uptake, increased the amount of [3H]5-HT found in the medium but did not fully block the uptake of [3H]5-HT in this slice preparation.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Richter JA,Jackson SKdoi
10.1007/BF00964710subject
Has Abstractpub_date
1980-07-01 00:00:00pages
719-30issue
7eissn
0364-3190issn
1573-6903journal_volume
5pub_type
杂志文章abstract::In this review we examine successively: 1) the major effects of thyroid hormone deficiency seen during brain development with special emphasis on the changes in neuronal morphology and migration occurring postnatally in the cerebellum. 2) The effects of this hormone on microtubule assembly during neurite outgrowth and...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF00965840
更新日期:1991-09-01 00:00:00
abstract::Rats were long-term morphine-intoxicated by a fluid-diet model ensuring an equal nutrient intake in morphinized and control rats. Uptake of neurotransmitters and D-ala2-met5-enkephalinamide (Enk) was studied in the particulate fractions (obtained at 10,000 g) from well defined brain regions of long-term intoxicated an...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967978
更新日期:1986-02-01 00:00:00
abstract::DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969627
更新日期:1989-02-01 00:00:00
abstract::We review here the possible mechanisms of neuronal degeneration caused by L-cysteine, an odd excitotoxin. L-Cysteine lacks the omega carboxyl group required for excitotoxic actions via excitatory amino acid receptors, yet it evokes N-methyl-D-aspartate (NMDA) -like excitotoxic neuronal death and potentiates the Ca2+ i...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1007616817499
更新日期:2000-10-01 00:00:00
abstract::Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1399-7
更新日期:2014-11-01 00:00:00
abstract::Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9311-3
更新日期:2007-08-01 00:00:00
abstract::The standard ELISA technique was improved for the detection of antigalactocerebroside antibody in biological fluid. Mouse monoclonal antigalactocerebroside antibody was used to demonstrate specificity and sensitivity of the technique. After optimization of the assay, the usefulness of this measurement for the evaluati...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971533
更新日期:1988-03-01 00:00:00
abstract::Growth-promoting macroglia (aldynoglia) with growth properties and immunological markers similar to Schwann cells, are found in loci of the mammalian CNS where axon regeneration occurs throughout life, like the olfactory sytem, hypothalamus-hypophysis and the pineal gland. Contrary to Schwann cells, aldynoglia mingle ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1026056921037
更新日期:2003-11-01 00:00:00
abstract::Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02753-0
更新日期:2020-03-01 00:00:00
abstract::S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9915-x
更新日期:2009-08-01 00:00:00
abstract::In this study, changes of the expression of two mitochondrial and two nuclear genes encoding the subunits of cytochrome c oxidase (CO) and NADH dehydrogenase (ND) were studied in the hippocampus, inferior parietal lobule, and cerebellum of 10 Alzheimer's disease (AD) and 10 age-matched control subjects. The altered pr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020783614031
更新日期:1999-06-01 00:00:00
abstract::The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) ...
journal_title:Neurochemical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1023/b:nere.0000026402.09466.54
更新日期:2004-07-01 00:00:00
abstract::Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2430-6
更新日期:2018-02-01 00:00:00
abstract::One hour incubation of rat cortical slices in a medium without oxygen and glucose (oxygen-glucose deprivation, OGD) increased S100B release to 6.53 ± 0.3 ng/ml/mg protein from its control value of 3.61 ± 0.2 ng/ml/mg protein. When these slices were then transferred to a medium containing oxygen and glucose (reoxygenat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1301-7
更新日期:2014-07-01 00:00:00
abstract::Tau is a protein involved in regulation of microtubule stability, axonal differentiation and transport. Alteration of retrograde transport may lead to motor neuron degeneration. Thus alternative mRNA splicing and expression of tau isoforms were studied in a transgenic mouse model harboring the human SOD1 G93A mutation...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9057-3
更新日期:2006-05-01 00:00:00
abstract::This study investigated the effects of aging on the actions of a specific glutamate reuptake blocker, L-trans-pyrrolidine-2, 4-dicarboxylic acid (PDC), in extracellular glutamate and glutamine in striatum of the awake rat. Microdialysis experiments were performed on young (2-3 months), middle-aged (12-14 months), aged...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007624531077
更新日期:2001-01-01 00:00:00
abstract::Prevention and amelioration of Mibyou (sub-healthy condition) is the critical target for disease prevention including age-related diseases and cancer although the Mibyou condition is not yet pathologically defined. Since the oxidative stress is an underlying basic etiology associated with many diseases and aging, the ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-008-9872-9
更新日期:2009-04-01 00:00:00
abstract::Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following inhaled anesthetics treatment can perturb cerebral homeostasis, which may be associated with their induced neurotoxicity. Seven-day-old rat ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1529-x
更新日期:2015-04-01 00:00:00
abstract::Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity ca...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1474-0
更新日期:2015-01-01 00:00:00
abstract::Pyridostigmine bromide (PB), an inhibitor of acetylcholinesterase, has been used as a prophylactic for nerve gas poisoning. N,N'-diethyl-m-toluamide (DEET) is the active ingredient in most insect repellents and is thought to interact synergistically with PB. Since PB can inhibit the binding of organophosphates to tubu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007527129743
更新日期:2000-01-01 00:00:00
abstract::Caspase activation and apoptotic events may take place in terminal regions far removed from the cell body and contribute to synapse loss in neurodegenerative diseases. For examination of events in terminals, we have developed a cell-free assay using quantitative flow cytometric analysis (fluorescence-activated cell so...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1019840417796
更新日期:2002-06-01 00:00:00
abstract::Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10-20% of patients with systemic lupus erythematosus (SLE). These antibodies inhibit protein synthesis in vitro and when microinjected into cultured human fibroblasts. The three proteins share a common epitope...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969925
更新日期:1990-04-01 00:00:00
abstract::Endogenous and xenobiotic sulphur-containing convulsant and non-convulsant compounds containing structural moieties of, or bearing a structural resemblance to, GABA and homocysteine were tested in binding studies for their potency in displacing the GABA-mimetic [3H]muscimol from specific, high-affinity sites (Kd = 3.6...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971006
更新日期:1987-07-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a degenerative disorder caused by motor neuron loss. T-cell intracellular antigen-1 (TIA-1), a cytotoxic T lymphocyte granule-associated RNA binding protein, is a key component of stress granules. However, it remains uncertain whether ALS-causing superoxide dismutase-1 (SOD1) tox...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03137-5
更新日期:2020-12-01 00:00:00
abstract::One of the main pathological symptoms of early diabetic retinal neuropathy is retina neuronal apoptosis. In the present work we investigated the effects of indoleamine hormone melatonin, a powerful free radical scavenger, on streptozotocin-induced retina neuronal cell apoptosis in high blood glucose rat. After melaton...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0966-z
更新日期:2013-03-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative disease that leads to progressive paralysis and inevitable death 3-5 years after diagnosis. The mechanisms underlying this process remain unknown, but new evidence indicates that accumulating levels of D-serine result from the downre...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2131-6
更新日期:2017-04-01 00:00:00
abstract::In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964696
更新日期:1983-05-01 00:00:00
abstract::The effect of hydrogen peroxide (H2O2) on cytosolic free calcium concentration ([Ca2+]c) as well as its effect on glutamate secretion in rat hippocampal astrocytes have been the aim of the present research. Our results show that 100 microM H2O2 induces an increase in [Ca2+]c, that remains at an elevated level while th...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9078-y
更新日期:2006-06-01 00:00:00
abstract::Probenecid inhibits the transport of the small monocarboxylic acids lactate and propionate from blood to brain but does not affect the transport of 5HIAA or HVA. Neither lactate, 5HIAA, HVA, nor probenecid itself inhibits probenecid uptake into brain from blood and neither lactate nor 5HIAA itself inhibits 5HIAA uptak...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965898
更新日期:1982-10-01 00:00:00
abstract::We studied the dose-response characteristics and the temporal profile of inhibition of brain nitric oxide (NO) synthase (NOS) elicited by i.v. administration of the NOS inhibitor nitro-L-arginine methyl ester (L-NAME). L-NAME was administered i.v. in awake rats equipped with a venous cannula. L-NAME was injected in cu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967330
更新日期:1994-04-01 00:00:00