Abstract:
:Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity caused by oxidative stress and pro-inflammation. We found that TC pretreatment significantly decreased seizure activity score compared to kainic acid treated group. Importantly, TC pretreatment leads to lowering the mortality in kainic acid treated mice. In addition, TC was found to significantly inhibit KA-induced generation of malondialdehyde. TC pretreatment also preserved the activity of GPx, SOD, and CAT. Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-α and IL-1β. These data suggest that TC has a potential protective effect on chemical induced seizure and brain damage.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Liu H,Song Z,Liao D,Zhang T,Liu F,Zhuang K,Luo K,Yang Ldoi
10.1007/s11064-014-1474-0subject
Has Abstractpub_date
2015-01-01 00:00:00pages
118-23issue
1eissn
0364-3190issn
1573-6903journal_volume
40pub_type
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