Abstract:
:Systemic inflammation is present in obesity and emerging evidence, primarily from studies using male rodents fed high-fat diets, suggests neuroimmune signaling also is involved. We investigated early changes in neuroimmune signaling during the weight gain that follows ovariectomy in rats. Ovariectomized (OVX) rats were given standard rat chow and terminated 5 days (baseline), 4 or 8 weeks after ovariectomy. Levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in plasma and periuterine adipose were not affected by ovariectomy. In contrast, compared to baseline levels, IL-6 expression in the arcuate nucleus (ARC) and dorsal vagal complex (DVC) decreased by 4 weeks after OVX, but was not affected in the paraventricular nucleus (PVN). MCP-1 expression decreased by 4 weeks in the ARC and by 8 weeks in the PVN, but was not affected in the DVC. Increased glial fibrillary acidic protein (GFAP) expression in the PVN indicated astrocyte activation; decreased toll-like receptor 4 (TLR4) expression in the ARC, but not other regions, suggested early effects on innate immune factors. Importantly, in reproductively intact rats, IL-6 and MCP-1 levels in plasma, periuterine adipose, and brain regions were not affected after 8 weeks. Unlike OVX rats, GFAP expression in the DVC of intact rats was decreased at 8 weeks, and TLR4 expression in the ARC was increased at 8 weeks. Taken together, these dynamic and selective changes in neuroimmune factors co-incident with post-ovariectomy weight gain provide insight into the role of neuroimmune signaling in obesity, particularly in females.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Curtis KS,McCracken K,Espinosa E,Ong J,Buck DJ,Davis RLdoi
10.1007/s11064-018-2596-6subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1802-1813issue
9eissn
0364-3190issn
1573-6903pii
10.1007/s11064-018-2596-6journal_volume
43pub_type
杂志文章abstract::The central control of growth hormone (GH) secretion from the pituitary gland is ultimately achieved by the interaction between two hypothalamic neurohormones, somatostatin which inhibits and growth hormone-releasing hormone (GHRH) which stimulates GH release. The regulation of the somatostatin and GHRH release from t...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-005-9017-3
更新日期:2006-02-01 00:00:00
abstract::Adaptive changes in serotonergic 5HT1 receptor signalling are believed to underlie the therapeutic effectiveness of antidepressant drugs. Since cells are continuously exposed to neurotransmitters/neuromodulators, spatially and temporally integrated, the responsiveness of a receptor system is dependent upon the physio-...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9582-8
更新日期:2008-07-01 00:00:00
abstract::Diisopropyl phosphorofluoridate (DFP) produces organophosphorus ester-induced delayed neurotoxicity (OPIDN) in sensitive species. We have investigated the in vivo and in vitro effects of DFP on hen brain tubulin polymerization. Hens were treated with a single dose of DFP (1.7 mg/kg, sc.), and were sacrificed after 18-...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967321
更新日期:1994-04-01 00:00:00
abstract::The elevated plus maze (EPM) is an animal model of anxiety used to test the effects of anxioselective drugs. The loss of the anxiolytic effect of drugs during the second exposure to the EPM is called the "one trial tolerance" (OTT) phenomenon. The present study was designed to investigate the relationship between the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1051-y
更新日期:2013-07-01 00:00:00
abstract::We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1185-y
更新日期:2013-12-01 00:00:00
abstract::There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced an...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2253-5
更新日期:2017-07-01 00:00:00
abstract::The cerebellar cortical circuit of mammals develops via a series of magnificent cellular events in the postnatal stage of development to accomplish the formation of functional circuit architectures. The contribution of genetic factors is thought to be crucial to cerebellar development. Therefore, it is essential to an...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-011-0398-1
更新日期:2011-07-01 00:00:00
abstract::Several epidemiological studies have shown that consumption of large quantities of vegetables especially cruciferous vegetables (Broccoli and Brussels sprouts) can protect against chronic diseases. Sulforaphane, an isothiocynate found in cruciferous vegetables has been demonstrated to have neuroprotective effects in s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1965-2
更新日期:2016-10-01 00:00:00
abstract::Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1803-y
更新日期:2016-05-01 00:00:00
abstract::Cell densities and respiratory rates of astrocytes from neonatal rat brain grown in primary culture were determined after 20-30 days in vitro. Cells grown in flasks reached lower densities (microgram DNA/cm2) and higher protein:DNA ratios than cells grown in petri dishes. Respiratory rates were lower for cells grown i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964355
更新日期:1981-12-01 00:00:00
abstract::The aim of the present study was to investigate possible membrane and genomic effects of corticosterone on the noradrenergic system of the rat brain. Corticosterone effects were studied in vivo by treating rats s.c. with 10 mg/kg corticosterone for 7 or 14 days. In the first two experiments corticosterone significantl...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966670
更新日期:1992-03-01 00:00:00
abstract::The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) ...
journal_title:Neurochemical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1023/b:nere.0000026402.09466.54
更新日期:2004-07-01 00:00:00
abstract::Germline mutations in genes encoding succinate dehydrogenase subunits are associated with the development of familial pheochromocytomas and paragangliomas [hereditary paraganglioma/pheochromocytoma syndrome (HPPS)]. In particular, a mutation in succinate dehydrogenase subunit B (SDHB) is highly associated with abdomin...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1738-3
更新日期:2016-04-01 00:00:00
abstract::Subunit-specific antibodies to all the gamma subunit isoforms described in mammalian brain (gamma(1), gamma(2S), gamma(2L), and gamma(3) have been made. The proportion of GABA(A) receptors containing each gamma subunit isoform in various brain regions has been determined by quantitative immunoprecipitation. In all tes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02529132
更新日期:1996-02-01 00:00:00
abstract::cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold or greater difference in normalized expression. RT-PCR analysis of a s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1026179926780
更新日期:2003-12-01 00:00:00
abstract::The synaptic glutamate level homeostasis is mainly maintained by the astrocytes membrane bound glutamate transporter type-1 (GLT-1/EAAT2). Alterations in its expression during development and aging and the underlying mechanisms are not well studied. Here, we report that NF-κB interaction was highest in both cerebral a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1200-3
更新日期:2014-01-01 00:00:00
abstract::Spinal cord injury (SCI) is a functional impairment of the spinal cord caused by external forces, accompanied by limb movement disorders and permanent paralysis, which seriously lowers the life quality of SCI patients. Secondary injury caused by inflammation attenuated the therapeutic effects of SCI. Therefore, the ex...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03211-y
更新日期:2021-01-13 00:00:00
abstract::Single prolonged stress (SPS) is one of the preclinical models of posttraumatic stress disorder (PTSD) in humans. Not every traumatized person develops PTSD and the onset of the disease varies from months to many years after exposure to life-threatening events. The pathogenetic neurometabolites in PTSD have not been i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2232-x
更新日期:2017-08-01 00:00:00
abstract::N-terminal protein arginylation has been demonstrated in vitro and in situ and has been reported to increase following injury to sciatic nerves of rats. The present study attempts to demonstrate these reactions in vivo by applying [3H]Arg to the cut end of sciatic nerves in anesthetized rats and assaying for N-termina...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021998227237
更新日期:1997-12-01 00:00:00
abstract::Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and hu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966825
更新日期:1992-10-01 00:00:00
abstract::The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was fou...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1012372115058
更新日期:2001-09-01 00:00:00
abstract::The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9439-1
更新日期:2008-03-01 00:00:00
abstract::The steady-state mRNA levels of NGF, BDNF and NT-3, and the mRNA levels of their receptors p75NGFR, trk, trkB, and trkC were examined in various human peripheral neuropathies, to determine the correlation with myelinated fiber pathology and T cell and macrophage invasions in the diseased nerves. Steady state levels of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022434209787
更新日期:1998-06-01 00:00:00
abstract::Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965512
更新日期:1989-12-01 00:00:00
abstract::We propose the following scheme for cerebral uptake and overall metabolism of glucose in vivo: that brain selects from two pools of glucose anomers in arterial blood, that it takes up excess glucose, that glucose enters the brain tissue as glucose-6-phosphate through the actions of mutarotase and hexokinase, that some...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964568
更新日期:1985-02-01 00:00:00
abstract::Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified thro...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966871
更新日期:1992-01-01 00:00:00
abstract::Hypothalamic and plasma dopamine-beta-hydroxylase [DBH, EC 1.14.2.1] activites were measured by a coupled radioenzymatic method. Animals representing five experimental groups [intact controls, adrenalectomized, pinealectomized, adrenalectomized pinealectomized, doubly sham-operated] were killed and sampled at 8 times ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965575
更新日期:1978-06-01 00:00:00
abstract::Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00974871
更新日期:1991-05-01 00:00:00
abstract::Donepezil is a selective inhibitor of acetylcholinesterase (AChE) clinically used for treating Alzheimer's disease. Cholinergic effects after short-term exposure of donepezil (up to 12 h) have been extensively studied in rats, but few have addressed the potential long-term effects. After 14 days administration (1x3 mg...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-8828-6
更新日期:2005-12-01 00:00:00
abstract::The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore established sensitive quantification methods and provided a rat ICH model for detection of ICH deterioration. In ICH intrastriatally induced by 0.014-unit, 0.070-unit, and 0.350-unit co...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022826220469
更新日期:2003-05-01 00:00:00