The Actin Cytoskeleton in Myelinating Cells.

abstract：:Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that a...

journal_title：Neurochemical research

authors： Xu ZP,Gan GS,Liu YM,Xiao JS,Liu HX,Mei B,Zhang JJ

更新日期：2018-02-01 00:00:00

abstract：:Multiple sclerosis (MS) is a demyelinating disease that affects the central nervous system. MS is the most common neurological disorder in young adults with a greater incidence among females. Male gonadal hormones have a protective effect on neural system development and myelin maturation. In this study, we investigat...

journal_title：Neurochemical research

authors： Sherafat MA,Javan M,Mozafari S,Mirnajafi-Zadeh J,Motamedi F

更新日期：2011-10-01 00:00:00

abstract：:Experimental hyperphenylalaninemia has been induced in 5-day-old chicks by dietary treatments with phenylalanine and alpha-methylphenylalanine. An increase of nearly 8-fold in plasma Phe/Tyr ratio was found after 4 days of supplementation the standard diet with 5% phenylalanine plus 0.4% alpha-methylphenylalanine. The...

journal_title：Neurochemical research

authors： Castillo M,Zafra MF,Garcia-Peregrin E

更新日期：1988-06-01 00:00:00

abstract：:The potent parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is known to cause dopaminergic neurodegeneration in nigrostriatal system. In the present study we investigated the nuclear morphology of cells in the substantia nigra pars compacta (SNpc) region of rats following unilateral intra...

journal_title：Neurochemical research

authors： Banerjee R,Sreetama S,Saravanan KS,Dey SN,Mohanakumar KP

更新日期：2007-07-01 00:00:00

abstract：:We recently presented evidence that distinct morphine and enkephalin receptors coexist in an opioid receptor complex (Mol. Pharmacol. 21:548-557, 1982). In this paper, we present data which demonstrate that in the presence of sodium leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to a crude pa...

journal_title：Neurochemical research

authors： Rothman RB,Westfall TC

更新日期：1983-07-01 00:00:00

abstract：:Prevention and amelioration of Mibyou (sub-healthy condition) is the critical target for disease prevention including age-related diseases and cancer although the Mibyou condition is not yet pathologically defined. Since the oxidative stress is an underlying basic etiology associated with many diseases and aging, the ...

journal_title：Neurochemical research

authors： Konishi T

更新日期：2009-04-01 00:00:00

abstract：:The control and maintenance of the intracellular redox state is an essential task for cells and organisms. NAD(+) and NADH constitute a redox pair crucially involved in cellular metabolism as a cofactor for many dehydrogenases. In addition, NAD(+) is used as a substrate independent of its redox-carrier function by enz...

journal_title：Neurochemical research

authors： Wilhelm F,Hirrlinger J

更新日期：2012-11-01 00:00:00

abstract：:Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...

journal_title：Neurochemical research

authors： Grassi S,Giussani P,Prioni S,Button D,Cao J,Hakimi I,Sarmiere P,Srinivas M,Cabitta L,Sonnino S,Prinetti A

更新日期：2019-06-01 00:00:00

abstract：:After rapid inactivation of the enzymes responsible for glucose metabolism by microwave irradiation, concentrations of glucose in 20 regions of the mouse brain were estimated with combined gas chromatography-mass spectrometry (GC-MS). The highest concentrations of glucose were found in the periventricular nuclei of th...

journal_title：Neurochemical research

authors： Shimada M,Kihara T,Watanabe M,Kurimoto K

更新日期：1977-12-01 00:00:00

abstract：:The present studies examined the inhibitory effect of veratridine (a Na+ channel activator) on carbachol (a cholinergic agonist) stimulated inositol 1,3,4,5-tetrakisphosphate accumulation in rat brain cortical slices. Veratridine inhibited carbachol stimulation of inositol 1,3,4,5-tetrakisphosphate formation (after a ...

journal_title：Neurochemical research

authors： Myles ME,Gokmen-Polar Y,Fain JN

更新日期：1995-09-01 00:00:00

abstract：:Correct timing and spatial location of growth factor expression is critical for undisturbed brain development and functioning. In terminally differentiated cells distinct biological responses to growth factors may depend on cell type specific activation of signalling cascades. We show that the hematopoietic growth fac...

journal_title：Neurochemical research

authors： Byts N,Samoylenko A,Woldt H,Ehrenreich H,Sirén AL

更新日期：2006-10-01 00:00:00

abstract：:Developing cellular models of sporadic Alzheimer's disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells (iPSCs) has revolutionised the opportunities to model AD pathology, in...

journal_title：Neurochemical research

authors： Rowland HA,Hooper NM,Kellett KAB

更新日期：2018-12-01 00:00:00

abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...

journal_title：Neurochemical research

authors： Strosznajder JB,Cieslik M,Cakala M,Jesko H,Eckert A,Strosznajder RP

更新日期：2011-05-01 00:00:00

abstract：:In the unrestrained rat, the hyperphagic-like ingestion of food evoked by the sustained elevation of neuropeptide-Y (NPY) in the hypothalamus was correlated with the release and turnover of monoaminergic transmitters in this structure. A single guide tube was implanted stereotaxically in the perifornical region of the...

journal_title：Neurochemical research

authors： Myers RD,Lankford MF,Paez X

更新日期：1992-11-01 00:00:00

abstract：:Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a cause and consequence of epileptic seizures. Although recent years have seen tremendous progress in the molecular biology and metabolism of selenium, we still know...

journal_title：Neurochemical research

authors： Nazıroglu M

更新日期：2009-12-01 00:00:00

abstract：:The activities of L-glutamate decarboxylase (GAD), GABA-transaminase (GABA-T), choline acetyltransferase (CAT), and cysteic and cysteinesulfinic acids decarboxylase (CAD/CSAD) in putamen and frontal cortex in both Huntington's chorea and normal tissues were measured. The greatest difference between Huntington's and no...

journal_title：Neurochemical research

authors： Wu JY,Bird ED,Chen MS,Huang WM

更新日期：1979-10-01 00:00:00

abstract：:The conversion of phosphoethanolamine to phosphocholine requires 3 separate N-methyltransferases. We had previously purified the enzyme catalyzing the last methylation, phosphodimethylethanolamine N-methyltransferase. We have successfully purified the enzyme catalyzing the initial methylation of phosphoethanolamine. A...

journal_title：Neurochemical research

authors： Mukherjee S,Freysz L,Kanfer JN

更新日期：1995-10-01 00:00:00

abstract：:Age related changes in brain cortex NO metabolism were investigated in mitochondria and cytosolic extracts from youth to adulthood. Decreases of 19%, 40% and 71% in NO production were observed in mitochondrial fractions from 3, 7, and 14 months old rats, respectively, as compared with 1-month-old rats. Decreased nNOS ...

journal_title：Neurochemical research

authors： Bustamante J,Czerniczyniec A,Cymeryng C,Lores-Arnaiz S

更新日期：2008-07-01 00:00:00

abstract：:We investigated the distribution of serotonin (5-HT) receptors of type 3 (5-HT3) in human brain areas, by means of the the specific binding of [3H]GR65630. The brains were obtained during autoptic sessions from 6 subjects. Human brain membranes and the binding of [3H]GR65630 were carried out according to standardized ...

journal_title：Neurochemical research

authors： Marazziti D,Betti L,Giannaccini G,Rossi A,Masala I,Baroni S,Cassano GB,Lucacchini A

更新日期：2001-03-01 00:00:00

abstract：:Glucocorticoid receptors (GRs) exert actions on the hippocampus that are important for memory formation. There are correlations between vascular dysfunctions and GR-related gene expression. Both vascular dysfunction and GR gene expression decline occur during the ageing process. Therefore, hypotensors, which have effe...

journal_title：Neurochemical research

authors： Li X,Ma J,Xu J,Zhu D,Li A,Che Y,Chen D,Feng X

更新日期：2017-11-01 00:00:00

abstract：:This study was designed to investigate the protective effects of extracellular superoxide dismutase (SOD3) against hydrogen peroxide (H2O2) induced damage in human neuroblastoma SH-SY5Y cells and to elucidate the mechanisms responsible for this beneficial effect. SOD3-overexpressing SH-SY5Y cells were generated by ade...

journal_title：Neurochemical research

authors： Yang R,Wei L,Fu QQ,Wang H,You H,Yu HR

更新日期：2016-07-01 00:00:00

abstract：:Excitotoxicity has been associated with the loss of medium spiny neurons (MSN) in Huntington's disease (HD). We have previously observed that the content of the glial glutamate transporters, glutamate transporter 1 (GLT-1) and glutamate-aspartate transporter (GLAST), diminishes in R6/2 mice at 14 weeks of age but not ...

journal_title：Neurochemical research

authors： Estrada-Sánchez AM,Montiel T,Massieu L

更新日期：2010-08-01 00:00:00

abstract：: ...

journal_title：Neurochemical research

authors： Choi IY,Schousboe A

更新日期：2019-01-01 00:00:00

abstract：:Zinc (Zn2+) was shown to invariably inhibit muscimol-stimulated 36Cl- uptake by synaptoneurosomes in the cerebral cortex, hippocampus and cerebellum. The Zn2+ sensitivity of the GABAA receptor-gated 36Cl- uptake in the cerebral cortex was comparable to that in the hippocampus, whereas the uptake in the cerebellum was ...

journal_title：Neurochemical research

authors： Ito Y,Segawa K,Kobayashi M,Fukuda H

更新日期：1996-08-01 00:00:00

abstract：:In vitro synthesis of myelin proteolipid protein (PLP) was explored at different ages using rat brain total homogenates, incubated for 30 min with [3H]glycine. Total proteolipids, extracted from the incubated samples, were separated by SDS-PAGE and the radioactivity was measured in the band corresponding to myelin PLP...

journal_title：Neurochemical research

authors： Bizzozero OA,Pasquini JM

更新日期：1984-09-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...

journal_title：Neurochemical research

authors： Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian AS

更新日期：1998-06-01 00:00:00

abstract：:This study evaluates whether physiological variables differentially affect the local synthesis of protein constituents of synapses in subcellular fractions containing pinched-off dendrites (synaptodendrosomes). Synaptodendrosomes were pulse-labeled in a medium containing 35S-methionine with 3 or 25 mM KCl and in the p...

journal_title：Neurochemical research

authors： Leski ML,Steward O

更新日期：1996-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia that progressively disrupts neurocognitive function, which has neither cure nor effective treatment. Hypercholesterolemia might be involved in brain alterations that could evolve into AD. The present study aims to evaluate the potential of omega-3, Co-enzyme...

journal_title：Neurochemical research

authors： Ibrahim Fouad G

更新日期：2020-05-01 00:00:00

abstract：:We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...

journal_title：Neurochemical research

authors： Luo H,Xu IS,Chen Y,Yang F,Yu L,Li GX,Liu FY,Xing GG,Shi YS,Li T,Han JS,Wan Y

更新日期：2008-10-01 00:00:00

abstract：:The present study addressed the hypothesis that the DA transporter ligand, [3H]mazindol, labels multiple sites/states associated with the dopamine (DA) transporter in striatal membranes. Incubations with [3H]mazindol proceeded for 18-24 hr at 4 degrees C in 55.2 mM sodium phosphate buffer, pH 7.4, with a protease inhi...

journal_title：Neurochemical research

authors： Dersch CM,Akunne HC,Partilla JS,Char GU,de Costa BR,Rice KC,Carroll FI,Rothman RB

更新日期：1994-02-01 00:00:00