Abstract:
:Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that adiponectin supplements significantly restored the cognitive deficits in ICV-STZ rat model including shorter escape latency, more crossing times and increased time spent in the target quadrant. Adiponectin supplements also increased number of dendritic branches and mushroom percentage. In addition, adiponectin supplements attenuated tau hyperphosphorylation at multiple AD-related sites through activation of protein Ser9-phosphorylated glycogen synthase kinase-3β (Ser9-GSK-3β) with increased the Akt and PI3K activity. Our data suggest that adiponectin supplements have neuroprotective effects on the ICV-STZ rat model, which may be mediated by the activation of the PI3K/Akt/GSK-3β signaling pathway.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Xu ZP,Gan GS,Liu YM,Xiao JS,Liu HX,Mei B,Zhang JJdoi
10.1007/s11064-017-2426-2subject
Has Abstractpub_date
2018-02-01 00:00:00pages
316-323issue
2eissn
0364-3190issn
1573-6903pii
10.1007/s11064-017-2426-2journal_volume
43pub_type
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