Abstract:
:The real time dynamics of K+ evoked neurosecretion in cerebellar slices has been monitored electrochemically. In the presence of 5-methyltetrahydrofolate a statistically significant diminution in secretory response occurs. Agonists to probe the pharmacological basis for this indicate it is not due to voltage sensitive Ca2+ channel blockade, nor does it show any similarity of effect with kainate, whose receptor is a putative binding site for 5-methyltetrahydrofolate. The method is fully validated, although no account is taken of individual molecular species. High performance liquid chromatography combined with off line microbiological assay could only detect 5-methyltetrahydrofolate in cerebrospinal fluid. We therefore discuss our findings in relation to possible cerebral roles for cerebrospinal fluid 5-methyltetrahydrofolate in the context of both membrane and transmitter related interactions.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Lucock MD,Levene MI,Hartley Rdoi
10.1007/BF00966940subject
Has Abstractpub_date
1993-05-01 00:00:00pages
617-23issue
5eissn
0364-3190issn
1573-6903journal_volume
18pub_type
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