Inhibitors of crayfish glutamic acid decarboxylase.

abstract：:Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adapt...

journal_title：Neurochemical research

authors： Cui H,Deng M,Zhang Y,Yin F,Liu J

更新日期：2018-03-01 00:00:00

abstract：:The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was fou...

journal_title：Neurochemical research

authors： Strunsky EG,Borisover MD,Nikolsky EE,Vyskocil F

更新日期：2001-09-01 00:00:00

abstract：:The pathophysiology of cerebral oedema (CE) in diabetic ketoacidosis (DKA) remains enigmatic. We investigated the role of the idiogenic osmol taurine and aquaporin channels in an in vitro model, the SH-SY5Y neuroblastoma cell line, by sequentially mimicking DKA-like hyperglycemia/hypertonicity and hypotonic fluid ther...

journal_title：Neurochemical research

authors： Koves IH,Russo VC,Higgins S,Mishra A,Pitt J,Cameron FJ,Werther GA

更新日期：2012-01-01 00:00:00

abstract：:It is well known that antioxidants containing sulfhydryl (-SH) groups are protective against the toxic effects of mercury. The current study was designed to elucidate the mechanism(s) of the cytoprotective effects of glutathione (GSH) and N-acetylcysteine (NAC) against the toxicity of inorganic mercury (HgCl(2)) in ne...

journal_title：Neurochemical research

authors： Becker A,Soliman KF

更新日期：2009-09-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) activity and levels of tyrosine were measured in whole brains from mice subjected to brief electric foot shock or to single or multiple injections of hydrocortisone acetate (HCA; 20 mg/kg). Adult brain tyrosine levels showed a rapid increase after either foot shock or a single injection of HC...

journal_title：Neurochemical research

authors： Diez JA,Sze PY,Ginsburg BE

更新日期：1977-04-01 00:00:00

abstract：:Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specif...

journal_title：Neurochemical research

authors： Freysz L,Farooqui AA,Horrocks LA,Massarelli R,Dreyfus H

更新日期：1991-11-01 00:00:00

abstract：:Beta-amyloid (Abeta) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Abeta on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Abeta(25-35) at 3 and 10 microM for 12 and 24 h followed by...

journal_title：Neurochemical research

authors： Buntup D,Skare O,Solbu TT,Chaudhry FA,Storm-Mathisen J,Thangnipon W

更新日期：2008-02-01 00:00:00

abstract：:Our previous studies have shown that three sigma (sigma) receptor ligands, (+)-N-allylnormetazocine ((+)-SKF-10,047), (+/-)-pentazocine and 1,3-di(2-tolyl)guanidine (DTG) differently regulated the dopamine (DA) transmission in the rat brain. In the present study, we attempted to clarify the role of sigma 1 receptor su...

journal_title：Neurochemical research

authors： Kobayashi T,Matsuno K,Murai M,Mita S

更新日期：1997-09-01 00:00:00

abstract：:Spinal cord injury (SCI), a severe health problem in worldwide, was commonly associated with functional disability and reduced quality of life. As the expression of brain-derived neurotrophic factor (BDNF) was substantial event in injured spinal cord, we hypothesized whether BDNF-overexpression could be in favor of th...

journal_title：Neurochemical research

authors： Chen MR,Dai P,Wang SF,Song SH,Wang HP,Zhao Y,Wang TH,Liu J

更新日期：2016-10-01 00:00:00

abstract：:Protein misfolding and deposition in the brain are implicated in the etiology of numerous neurodegenerative disorders. Here, organic solutes characteristic of microorganisms adapted to hot environments, were tested on experimental cell models of Huntington's and Parkinson's diseases. Diglycerol phosphate, di-myo-inosi...

journal_title：Neurochemical research

authors： Jorge CD,Ventura R,Maycock C,Outeiro TF,Santos H,Costa J

更新日期：2011-06-01 00:00:00

abstract：:Several lines of evidence suggest that the mechanism underlying drug-induced neuronal apoptosis is initiated by the increased production of reactive oxygen species (ROS). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin, has been shown to initiate an apoptotic cascade by increasing ROS in the dopamine...

journal_title：Neurochemical research

authors： Nopparat C,Porter JE,Ebadi M,Govitrapong P

更新日期：2014-02-01 00:00:00

abstract：:Danhong injection, a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is used extensively for the treatment of cerebrovascular diseases such as acutely cerebral infarction in clinic. In this study, we further investigated the mechanisms of Danhong inje...

journal_title：Neurochemical research

authors： Guo H,Li MJ,Liu QQ,Guo LL,Ma MM,Wang SX,Yu B,Hu LM

更新日期：2014-09-01 00:00:00

abstract：:Growth-promoting macroglia (aldynoglia) with growth properties and immunological markers similar to Schwann cells, are found in loci of the mammalian CNS where axon regeneration occurs throughout life, like the olfactory sytem, hypothalamus-hypophysis and the pineal gland. Contrary to Schwann cells, aldynoglia mingle ...

journal_title：Neurochemical research

authors： Nieto-Sampedro M

更新日期：2003-11-01 00:00:00

abstract：:Parkinson's disease (PD) is a severe neurodegenerative disease characterized by selective loss of dopaminergic neurons, which reduces quality of life of patients and poses a heavy burden to the society. The pathological mechanism of PD remains unclear, and increasing efforts are aimed to solve this problem. MiRNAs are...

journal_title：Neurochemical research

authors： Dong Y,Xiong J,Ji L,Xue X

更新日期：2020-11-12 00:00:00

abstract：:The effect of optic nerve transsection on proteolytic degradation of axonally transported proteins in the superior colliculus of the rabbit was studied. Proteolysis of labeled proteins was determined in vitro in small pieces of the superior colliculus. Within 2 hours after sectioning the optic nerve there was a decrea...

journal_title：Neurochemical research

authors： Gustavsson S,Karlsson JO

更新日期：1988-07-01 00:00:00

abstract：:gamma-L-Glutamylglutamate (LGG), an endogenous constituent of the brain, reduced the glutamate-evoked increase in intracellular Ca2+ in cultured cerebellar granule cells. The extent and properties of this inhibition were different at different Mg2+ concentrations. The intracellular Ca2+ response to NMDA was slightly e...

journal_title：Neurochemical research

authors： Varga V,Janáky R,Holopainen I,Oja SS,Akerman KE

更新日期：1995-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common neurodegenerative condition that affects the elderly population. Its primary symptom is memory loss. The memory dysfunction in AD has been associated with cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM). Zizyphus jujube (ZJ) a...

journal_title：Neurochemical research

authors： Rabiei Z,Rafieian-Kopaei M,Heidarian E,Saghaei E,Mokhtari S

更新日期：2014-02-01 00:00:00

abstract：:Chlorpyrifos (CPF), an organophosphorus insecticide is known to cause ill health in non-target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-related differences and vulnerability in ...

journal_title：Neurochemical research

authors： Basha PM,Poojary A

更新日期：2011-02-01 00:00:00

abstract：:Several methods have been described previously for the purification of the nervous-tissue specific protein kinase C substrate B-50 (GAP-43). In this paper we present a new purification method for B-50 from rat brain which employs 2-mercaptoethanol to release the protein from isolated synaptosomal plasma membranes. Mos...

journal_title：Neurochemical research

authors： De Graan PN,Moritz A,de Wit M,Gispen WH

更新日期：1993-08-01 00:00:00

abstract：:Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were adminis...

journal_title：Neurochemical research

authors： Yardım A,Kandemir FM,Çomaklı S,Özdemir S,Caglayan C,Kucukler S,Çelik H

更新日期：2020-11-17 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...

journal_title：Neurochemical research

authors： Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian AS

更新日期：1998-06-01 00:00:00

abstract：:It is an honour to have this opportunity write an article in recognition of the immense contributions of Bruce Ransom to the field of glial research. For me (BAM) personally there are many highlights both as a colleague and a friend that come to mind when I reflect on the many years that I have known Bruce. My own ent...

journal_title：Neurochemical research

authors： MacVicar BA,Choi HB

更新日期：2017-09-01 00:00:00

abstract：:The spontaneously hypertensive rat (SHR) has been proposed as an animal model for attention-deficit hyperactivity disorder (ADHD). The behavioural problems have been suggested to be secondary to altered reinforcement mechanisms in which nucleus accumbens dopaminergic activity plays an important role. Interaction betwe...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Sagvolden T,Searson A,Jaffer A,Taljaard JJ

更新日期：1995-04-01 00:00:00

abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...

journal_title：Neurochemical research

authors： Pei DS,Sun YF,Song YJ

更新日期：2009-08-01 00:00:00

abstract：:Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...

journal_title：Neurochemical research

authors： Shen Y,Zhao H,Li P,Peng Y,Cui P,Miao F,Zhang Y,Zhang A,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:The present study has attempted to elucidate the alteration of serotonin turnover after 24 h REM sleep deprivation in different regions in brain of young rat. Sleep deprivation was induced by the inverted flower pot technique. Results of this study show increased serotonin turnover after 24 h REM sleep deprivation in ...

journal_title：Neurochemical research

authors： Senthilvelan M,Ravindran R,Samson J,Devi RS

更新日期：2006-01-01 00:00:00

abstract：:Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD pati...

journal_title：Neurochemical research

authors： Andreoli V,Nicoletti G,Romeo N,Condino F,La Russa A,Liguori M,Manna I,Spadafora P,Quattrone A,Cittadella R

更新日期：2007-09-01 00:00:00

abstract：:Passive avoidance (PA) conditioning is a fear motivated task able to initiate a cascade of altered gene expression within the hippocampus, a structure critical to learning and memory. We have previously shown that neurofibromin (NF1) and amyloid precursor protein (APP), two genes implicated in cognitive function, are ...

journal_title：Neurochemical research

authors： D'Amico AG,Castorina A,Leggio GM,Drago F,D'Agata V

更新日期：2013-03-01 00:00:00

abstract：:The control and maintenance of the intracellular redox state is an essential task for cells and organisms. NAD(+) and NADH constitute a redox pair crucially involved in cellular metabolism as a cofactor for many dehydrogenases. In addition, NAD(+) is used as a substrate independent of its redox-carrier function by enz...

journal_title：Neurochemical research

authors： Wilhelm F,Hirrlinger J

更新日期：2012-11-01 00:00:00

abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...

journal_title：Neurochemical research

authors： Rath MF,Rohde K,Klein DC,Møller M

更新日期：2013-06-01 00:00:00