Abstract:
:Alzheimer's disease (AD) is the most common form of dementia in the aged population. Early-onset familial AD (FAD) involves mutations in a gene on chromosome 21 encoding the amyloid protein precursor or on chromosomes 14 or 1 encoding genes known as presenilins. All mutations examined have been found to increase the production of amyloidogenic forms of the amyloid protein (A beta), a 4 kDa peptide derived from APP. Despite the remarkable progress in elucidating the biochemical mechanisms responsible for AD, little is known about the normal function of APP. A model of how APP and A beta are involved in pathogenesis is presented. This model may explain why certain neuronal populations are selectively vulnerable in AD. It is suggested that those neurons which more readily undergo neuritic sprouting and synaptic remodelling are more vulnerable to A beta neurotoxicity.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Small DHdoi
10.1023/a:1022471729291subject
Has Abstractpub_date
1998-05-01 00:00:00pages
795-806issue
5eissn
0364-3190issn
1573-6903journal_volume
23pub_type
杂志文章,评审abstract::Protein kinase C (PKC) plays a key role in cellular events including proliferation, survival and differentiation. Our previous study showed the effect of phorbol 12-myristate 13-acetate (PMA), a PKC activator, inducing a decrease in retinal cells proliferation. This effect was mediated by muscarinic type 1 receptors (...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9847-x
更新日期:2009-05-01 00:00:00
abstract::Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1025678510480
更新日期:2003-10-01 00:00:00
abstract::Regional cerebral glucose utilization (RCGU) and behavior were studied during naloxone-precipitated withdrawal in rats after chronic intravenous (IV) or intracerebroventricular (ICV) administration of sufentanil citrate, a potent, highly selective mu opiate agonist. Changes in RCGU were indistinguishable between the t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01006813
更新日期:1994-10-01 00:00:00
abstract::Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2595-7
更新日期:2018-09-01 00:00:00
abstract::Secretases degrade amyloid precursor protein (APP) releasing fragments (beta-peptides A beta, A beta x) that assemble to form hallmark extracellular deposits in Alzheimer's disease (AD) correlating with disease severity. As such, secretases supply targets for therapeutic intervention and form the focus of this overvie...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1023211323853
更新日期:2003-07-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1603-4
更新日期:2015-07-01 00:00:00
abstract::A panel of mouse monoclonal antibodies to rat and human myelin-associated glycoprotein (MAG) was developed. Normal mice were unresponsive to rat MAG, and successful immunization with rat MAG was only achieved in autoimmune NZB mice. By contrast, all strains of mice were responsive to human MAG. The monoclonal antibodi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964654
更新日期:1985-04-01 00:00:00
abstract::The JNKs have been implicated in a variety of biological functions in mammalian cells, including apoptosis and the responses to stress. However, the physiological role of these pathways in the intracerebral hemorrhage (ICH) has not been fully elucidated. In this study, we identified a MAPK kinase kinase (MAPKKK), MEKK...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2063-1
更新日期:2016-12-01 00:00:00
abstract::We have shown that acute ammonia toxicity is mediated by activation of the NMDA type of glutamate receptors. Although it is well known that L-carnitine prevents acute ammonia toxicity, the underlying molecular mechanism is not clear. We suspected that L-carnitine would prevent ammonia toxicity by preventing the toxic ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971588
更新日期:1994-03-01 00:00:00
abstract::The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-rel...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2544-5
更新日期:2018-06-01 00:00:00
abstract::Hemin is a breakdown product of the blood protein, hemoglobin and is responsible for much of the secondary damage caused following a hemorrhagic stroke. Hemin is toxic to cultured astrocytes and it is thought that this toxicity is due to iron that is liberated when hemin is degraded. However, free iron applied to astr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1795-7
更新日期:2016-02-01 00:00:00
abstract::Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02734-3
更新日期:2019-04-01 00:00:00
abstract::3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington's disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. (1)H NMR spectroscopy was used to ch...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9904-5
更新日期:2009-07-01 00:00:00
abstract::Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in re...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965332
更新日期:1986-05-01 00:00:00
abstract::The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965738
更新日期:1990-10-01 00:00:00
abstract::Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adapt...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2469-z
更新日期:2018-03-01 00:00:00
abstract::Radioactive 125I seeds-based radiotherapy has achieved great success in treatment of human cancers. However, radioresistance and severe side effects badly limited its clinic application. Recently, chemoradiotherapy as a superior strategy has been rapidly developed and widely used in clinic. However, the underlying mec...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2547-2
更新日期:2018-07-01 00:00:00
abstract::In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964981
更新日期:1985-10-01 00:00:00
abstract::The ability of Sendai virosomes or Lipofectin to introduce an AAV vector into primary rat brain astroglial cultures was characterized. The pJDT95npy vector was constructed by inserting rat NPY cDNA downstream from the indigenous AAV p5, p19 and p40 promoters in pJDT95. Lipofectin-mediated transfection with pJDT95npy (...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967701
更新日期:1994-06-01 00:00:00
abstract::Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965512
更新日期:1989-12-01 00:00:00
abstract::The presynaptic dopamine (DA) D2 receptor-mediated regulation of ATP-sensitive potassium (K+ATP) channels was examined in slices of the rat caudate-putamen. When slices were incubated with the specific D2 receptor antagonist (-)-sulpiride (SLP), a concentration-dependent increase of extracellular DA release was observ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1026620316090
更新日期:2000-12-01 00:00:00
abstract::The serotoninergic system modulates nociceptive and locomotor spinal cord circuits. Exercise improves motor function and changes dopaminergic, noradrenergic, and serotonergic central systems. However, the direct relationship between serotonin, peripheral nerve lesion and aerobic treadmill exercise has not been studied...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-0066-x
更新日期:2010-03-01 00:00:00
abstract::(E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine (HOEC), a naturally caffeic ester isolated from Incarvillea mairei, has been reported to possess anti-inflammatory activity by targeting 5-lipoxygenase. However, its other potential activities have yet to be explored. In this study, we measured antioxidant activity of ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1498-5
更新日期:2015-03-01 00:00:00
abstract::Hydroxysafflor yellow A (HSYA) is a component of the flower Carthamus tinctorius L. that elicits neuroprotective effects in vivo and in vitro. The purpose of this study was to investigate pharmacological properties of HSYA on neurotoxicity of glutamate in primary cultured rat cortical neurons along with its possible m...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0191-6
更新日期:2010-09-01 00:00:00
abstract::There is evidence that many of the GABA(A) receptor subunits contain consensus sequence for tyrosine kinase, and phosphorylation may play a key role in ethanol's regulation of GABA(A) receptors. Recently, we investigated the effect of chronic exposure of ethanol (CE) on tyrosine kinase phosphorylation and reported tha...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9124-9
更新日期:2006-09-01 00:00:00
abstract::Tau is a protein involved in regulation of microtubule stability, axonal differentiation and transport. Alteration of retrograde transport may lead to motor neuron degeneration. Thus alternative mRNA splicing and expression of tau isoforms were studied in a transgenic mouse model harboring the human SOD1 G93A mutation...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9057-3
更新日期:2006-05-01 00:00:00
abstract::Previous studies have shown that early life stress induced by maternal separation or non-handling can lead to behavioural deficits in rats and that these deficits can be alleviated by providing palatable cafeteria high-fat diet (HFD). In these studies we investigated the effects of maternal separation or non-handling ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-0985-4
更新日期:2013-04-01 00:00:00
abstract::Exposure to Hg2+ below 10 micrometer destroys synaptosomal membrane-associated sialidase of bovine brain in situ. Inhibition by Cu2+ occurs only at relatively higher concentrations, and is demonstrable after the synaptosomal membrane preparation has been presaturated with Cu2+ . Pb2+ does not inhibit enzymatic activit...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964363
更新日期:1978-02-01 00:00:00
abstract::Alzheimer's disease is a neurodegenerative disease characterized by the production of β-amyloid proteins and hyperphosphorylation of tau protein. Inflammation and apoptotic severity were highly correlated with earlier age at onset of Alzheimer's disease and were also associated with cognitive decline. This study aims ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0866-2
更新日期:2012-12-01 00:00:00
abstract::The effect of ageing and the relationships between the catalytic properties of enzymes linked to Krebs' cycle, electron transfer chain, glutamate and aminoacid metabolism of cerebral cortex, a functional area very sensitive to both age and ischemia, were studied on mitochondria of adult and aged rats, after complete i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-0004-y
更新日期:2009-12-01 00:00:00