Abstract：
:This study was designed to investigate the effects of chronic toluene inhalation in high concentration on lipid peroxidation, antioxidant enzyme activities and ultrastructural changes in the sciatic nerves of rats. Male Wistar albino rats (150-250 g) were divided in two experimental groups: the control and the toluene treated group (n = 10 for each). Toluene treatment was performed by inhalation of 3000 ppm toluene, in a 8 h/day and 6 day/week order for 16 weeks. Blood and tissue samples were obtained for biochemical and histopathological investigation. The blood and sciatic nerves were assayed for toluene by gas chromatography. Toluene significantly increased blood and tissue malondialdehyde (MDA), and decreased tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), but not tissue catalase (CAT) levels when compared with controls. Electron micrographs of sciatic nerve in the toluene group shows myelin destructions with onion-bulb and bubble form protrusion on the myelin sheath and axolemma border of myelinated axons. The area of injury on the myelin sheath were measured by Image-Pro Plus. Mean of the injury area were estimated 34% each myelin. These findings indicate that chronic toluene inhalation might be involved with free radical processes.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Coskun O,Oter S,Korkmaz A,Armutcu F,Kanter Mdoi
10.1007/s11064-004-9683-6keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
33-8issue
1eissn
0364-3190issn
1573-6903journal_volume
30pub_type
杂志文章abstract：:The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore established sensitive quantification methods and provided a rat ICH model for detection of ICH deterioration. In ICH intrastriatally induced by 0.014-unit, 0.070-unit, and 0.350-unit co...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022826220469
更新日期：2003-05-01 00:00:00
abstract：:Exposure chronically to n-hexane produces peripheral-central axonopathy mediated by 2,5-hexanedione (HD). Previous studies have demonstrated decreases in neurofilament (NF) contents of peripheral and central nervous regions from rats intoxicated with HD, and recent analysis has demonstrated that axonal atrophy, instea...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-2439-5
更新日期：2005-02-01 00:00:00
abstract：:Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1399-7
更新日期：2014-11-01 00:00:00
abstract：:Effects of single and repeated doses of acrylamide on fast and slow axonal transport of radio labeled proteins following the injection of L-[4,5-3H] leucine have been studied in the optic system of male Sprague-Dawley rats. A single dose of acrylamide (100 mg/kg) had no effect, but higher concentrations (200-300 mg/kg...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973750
更新日期：1990-06-01 00:00:00
abstract：:Rabbits sensitized with whole nervous tissue or myelin basic protein (MBP) plus adjuvant and developing experimental allergic encephalomyelitis (EAE) were studied for the presence of oligoclonal immunoglobulin (Ig) bands in spinal fluid and serum. Samples obtained prior to sensitization and at the time of sacrifice we...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963909
更新日期：1981-01-01 00:00:00
abstract：:Acidosis (pH 6.0) led to significant decrease in high-affinity choline uptake by rat brain synaptosomes. The effects persisted following pH readjustment (7.4) of the incubation medium, consisting of decrease in both Km and Vmax of the affinity system. pH readjustment coincided with synaptosomal leakage of lactate dehy...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969699
更新日期：1995-07-01 00:00:00
abstract：:Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such as ischemic stroke. In this study, we examined the neuroprotective effect of TsI against ischemic damage and its neuroprotective mecha...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1312-4
更新日期：2014-07-01 00:00:00
abstract：:Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for ty...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0433-2
更新日期：2011-09-01 00:00:00
abstract：:The present study was designed to evaluate the potential role of miR-93 in cerebral ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice via middle cerebral artery occlusion (MCAO) for 1 h followed by reperfusion. And miR-93 antagomir was transfected to down-regulate the miR-93 le...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1975-0
更新日期：2016-10-01 00:00:00
abstract：:Populations of enriched glial precursor cells and astrocytes isolated from primary cultures of newborn rat brain were used to study the synthesis of sulfated glycoproteins. Both cell types incorporated [3H]glucosamine and [35S]sulfate into carbohydrate side chains of proteoglycans and glycoproteins. The rate of incorp...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965947
更新日期：1986-08-01 00:00:00
abstract：:DYT1 dystonia is caused by a glutamic acid deletion (ΔE) in the endoplasmic reticulum (ER) protein torsinA. Previous studies suggest that torsinA modulates the aggregation of cytosolic misfolded proteins and ER stress responses, although the mechanisms underlying those effects remain unclear. In order to investigate t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0363-4
更新日期：2011-03-01 00:00:00
abstract：:The steady-state mRNA levels of NGF, BDNF and NT-3, and the mRNA levels of their receptors p75NGFR, trk, trkB, and trkC were examined in various human peripheral neuropathies, to determine the correlation with myelinated fiber pathology and T cell and macrophage invasions in the diseased nerves. Steady state levels of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022434209787
更新日期：1998-06-01 00:00:00
abstract：:We have attempted to show eventual modifications in the brain protein synthesis apparatus of rat during the first three weeks after birth. Through this time we noted a steady decrease (about 60%) in the free polysomes, when expressed relative to tissue weight. This decrease does not correlate with changes in the polys...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966130
更新日期：1986-09-01 00:00:00
abstract：:The current study investigated the neuroprotective activity of idebenone against pilocarpine-induced seizures and hippocampal injury in rats. Idebenone is a ubiquinone analog with antioxidant, and ATP replenishment effects. It is well tolerated and has low toxicity. Previous studies reported the protective effects of ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1236-z
更新日期：2014-02-01 00:00:00
abstract：:Silibinin has been widely used to treat liver diseases due to its antioxidant activity. However, the effects of silibinin on the central nervous system have not been thoroughly investigated. The pathological hallmarks of Alzheimer's disease are the accumulation of amyloid β protein, development of neurofibrillary tang...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2389-3
更新日期：2017-12-01 00:00:00
abstract：:The present study has attempted to elucidate the alteration of serotonin turnover after 24 h REM sleep deprivation in different regions in brain of young rat. Sleep deprivation was induced by the inverted flower pot technique. Results of this study show increased serotonin turnover after 24 h REM sleep deprivation in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-9139-7
更新日期：2006-01-01 00:00:00
abstract：:Role of the orexinergic system in pain modulation is well studied and involvement of the spinal orexin-1 receptors is well documented. In this study, we examined role of the spinal orexin-2 receptors in modulation of inflammatory pain in rat. Fifty-one adult male Wistar rats were implanted unilaterally with a guide ca...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02749-w
更新日期：2019-05-01 00:00:00
abstract：:The insoluble fraction of ox-brain, which had previously been shown to have a non-linear affinity for Na+ and K+, was prepared. Acetylcholine (1 x 10(-8) mol/l and 1 x 10(-7) mol/l) reduced the affinity of the fraction for Na+ and K+ to zero, while at 1 x 10(-6) mol/l, the affinity for the cations was almost as high a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969636
更新日期：1989-02-01 00:00:00
abstract：:We investigated the ability of hydrogen peroxide (H2O2) to cause apoptotic cell death in cultured rat forebrain neurons and the potential mechanisms by which oxidative stress triggers delayed neuronal death. H2O2 (25 microM for 5 min) reduced cell viability to 34.5 +/- 8.3% of untreated controls 20 h after exposure, a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022403224901
更新日期：1997-03-01 00:00:00
abstract：:We investigated the action of the new hypothalamic proline-rich peptide (PRP-1), normally produced by neurosecretory cells of hypothalamic nuclei (NPV and NSO), 3 and 4 weeks following rat sciatic nerve transection. The impulse activity flow of interneurons (IN) and motoneurons (MN) on stimulation of mixed (n. ischiad...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-2685-1
更新日期：2005-04-01 00:00:00
abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-006-9128-5
更新日期：2007-04-01 00:00:00
abstract：:The action of electroacupuncture (EA) may be similar to analgesia by electrode stimulation or transcutaneous nerve stimulation. Since EA may directly stimulate nerve activity or indirectly enhance the release of opiate peptides and other neurotransmitter substances, we have used (Na+ + K+)-ATPase as a model to study t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964513
更新日期：1984-05-01 00:00:00
abstract：:Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1840-1
更新日期：2016-06-01 00:00:00
abstract：:The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9187-7
更新日期：2007-02-01 00:00:00
abstract：:Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00974871
更新日期：1991-05-01 00:00:00
abstract：:The volume-regulated anion channel, VRAC, plays an important role in cell volume regulation. This channel is permeable for a wide variety of anions, amino acids, and organic osmolytes, including taurine. However, nothing is known about possible water permeability of this channel. Water permeability of endothelial cell...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000010430.23137.be
更新日期：2004-01-01 00:00:00
abstract：:Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2676-7
更新日期：2019-02-01 00:00:00
abstract：:Neuronal differentiation and aging are known to involve many genes, which may also be differentially expressed during these developmental processes. From primary cultured cerebral cortical neurons, we have previously identified various differentially expressed gene transcripts from cultured cortical neurons using the ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-8800-5
更新日期：2005-10-01 00:00:00
abstract：:Excitatory and inhibitory neurotransmission in the central nervous system can be modulated by neurosteroids. We previously found that in rat hippocampal slices allopregnanolone (3α-hydroxy-5α-pregnan-20-one), a positive GABA(A) receptor modulator, suppresses the epileptic discharges induced by 4-aminopyridine (4-AP), ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0649-1
更新日期：2012-03-01 00:00:00
abstract：:The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic ac...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967746
更新日期：1986-12-01 00:00:00
