Antioxidative and Anti-Apoptotic Roles of Silibinin in Reversing Learning and Memory Deficits in APP/PS1 Mice.

abstract：:Pyridostigmine bromide (PB), an inhibitor of acetylcholinesterase, has been used as a prophylactic for nerve gas poisoning. N,N'-diethyl-m-toluamide (DEET) is the active ingredient in most insect repellents and is thought to interact synergistically with PB. Since PB can inhibit the binding of organophosphates to tubu...

journal_title：Neurochemical research

authors： Prasad V,Scotch R,Chaudhuri AR,Walss C,Fathy DB,Miller C,Ludueña RF

更新日期：2000-01-01 00:00:00

abstract：:The three essential amino acids, valine, leucine and isoleucine, constitute the group of branched-chain amino acids (BCAAs). BCAAs are rapidly taken up into the brain parenchyma, where they serve several distinct functions including that as fuel material in brain energy metabolism. As one function of astrocytes is con...

journal_title：Neurochemical research

authors： Murín R,Mohammadi G,Leibfritz D,Hamprecht B

更新日期：2009-07-01 00:00:00

abstract：:Human dental follicle cells (DFCs) are ectomesenchymal multipotent stem cells that form spheroid cell clusters (SCCs) under serum free medium cell culture conditions (SFM). Until today, molecular mechanisms for the formation of SCCs are unknown. In this study a quantitative phosphoproteomics approach revealed regulate...

journal_title：Neurochemical research

authors： Beck HC,Gosau M,Kristensen LP,Morsczeck C

更新日期：2014-07-01 00:00:00

abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...

journal_title：Neurochemical research

authors： Hao G,Dong Y,Huo R,Wen K,Zhang Y,Liang G

更新日期：2016-06-01 00:00:00

abstract：:In this review article, we summarize recently accumulated knowledge regarding the molecular mechanisms, which control retinal development. Retinal neurons are born in two waves of cytogenesis. In the first wave, neurons of cone circuitry are generated, whereas in the second wave, rod circuitry is added. Neurons genera...

journal_title：Neurochemical research

authors： Sharma RK,Johnson DA

更新日期：2000-10-01 00:00:00

abstract：:Folic acid plays an important role in neuroplasticity and acts as a neuroprotective agent, as observed in experimental brain ischemia studies. The aim of this study was to investigate the effects of folic acid on locomotor activity, aversive memory and Na(+),K(+)-ATPase activity in the frontal cortex and striatum in a...

journal_title：Neurochemical research

authors： Carletti JV,Deniz BF,Miguel PM,Rojas JJ,Kolling J,Scherer EB,de Souza Wyse AT,Netto CA,Pereira LO

更新日期：2012-08-01 00:00:00

abstract：:Evidence that brain glutamatergic activity is pathologically elevated in bipolar disorder suggests that mood stabilizers are therapeutic in the disease in part by downregulating glutamatergic activity. Such activity can involve the second messenger, arachidonic acid (AA, 20:4n - 6). We tested this hypothesis with rega...

journal_title：Neurochemical research

authors： Basselin M,Chang L,Chen M,Bell JM,Rapoport SI

更新日期：2008-11-01 00:00:00

abstract：:The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high levels of Glu at synapses during aging, we used transgenic (Tg) mice that over-express the enzyme ...

journal_title：Neurochemical research

authors： Choi IY,Lee P,Wang WT,Hui D,Wang X,Brooks WM,Michaelis EK

更新日期：2014-01-01 00:00:00

abstract：:The influence of phosphatidylserine (PS) on the isoniazid-induced convulsions has been studied in mice. Sonicated dispersions of this phospholipid given intravenously do not show anticonvulsant activity but they do so when gamma-aminobutyric acid (GABA) is simultaneously injected. GABA alone is inactive. The synergism...

journal_title：Neurochemical research

authors： Toffano G,Mazzari S,Zanotti A,Bruni A

更新日期：1984-08-01 00:00:00

abstract：:This study was designed to investigate the protective effects of extracellular superoxide dismutase (SOD3) against hydrogen peroxide (H2O2) induced damage in human neuroblastoma SH-SY5Y cells and to elucidate the mechanisms responsible for this beneficial effect. SOD3-overexpressing SH-SY5Y cells were generated by ade...

journal_title：Neurochemical research

authors： Yang R,Wei L,Fu QQ,Wang H,You H,Yu HR

更新日期：2016-07-01 00:00:00

abstract：:Caspase activation and apoptotic events may take place in terminal regions far removed from the cell body and contribute to synapse loss in neurodegenerative diseases. For examination of events in terminals, we have developed a cell-free assay using quantitative flow cytometric analysis (fluorescence-activated cell so...

journal_title：Neurochemical research

authors： Gylys KH,Fein JA,Cole GM

更新日期：2002-06-01 00:00:00

abstract：:Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 microM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates ge...

journal_title：Neurochemical research

authors： Panchal HD,Vranizan K,Lee CY,Ho J,Ngai J,Timiras PS

更新日期：2008-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterized by presence of senile plaques in the hippocampus, which are composed mainly of extracellular deposition of a polypeptide known as the beta amyloid, the Aβ. It has been demonstrated on numerous occasions that it was the deposition and aggregation of this Aβ pepti...

journal_title：Neurochemical research

authors： Yang HQ,Li X,Yang WM,Feng SM,Ma JJ

更新日期：2012-10-01 00:00:00

abstract：:The pathophysiological mechanism(s) underlying Alzheimer's disease (AD) still remain unclear, and no disease-modifying or prophylactic therapies are currently available. Unraveling the fundamental neuropathogenesis of AD is an important challenge. Several studies on AD have suggested lesions in a number of CNS areas i...

journal_title：Neurochemical research

authors： Daulatzai MA

更新日期：2012-04-01 00:00:00

abstract：:Ochratoxin A (OA) is a mycotoxin produced by several storage fungi, such as Aspergillus ochraceus and several Penicillium species. OA (3 mg/kg) was given intraperitoneally to pregnant mice on day 11 of gestation (day 1 = day of insemination), and neurochemical changes in brains of their offspring were examined at feta...

journal_title：Neurochemical research

authors： Tamaru M,Hirata Y,Matsutani T

更新日期：1988-12-01 00:00:00

abstract：:In vitro aggregation and fibrillization of synthetic amyloid beta-protein Abeta 1-40 was assessed in the conditioned media from rhabdomyosarcoma (CRL 1598, HTB 82, HTB 153, CCL 136), adenocarcinoma (CCL 218), neuroblastoma (SY5Y), and COS cells cultured in the absence and presence of 10% heat-inactivated fetal bovine ...

journal_title：Neurochemical research

authors： Chauhan A,Chauhan VP,Rubenstein R,Wegiel J,Wisniewski HM

更新日期：1997-02-01 00:00:00

abstract：:Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is known about this important topic. In the present study, we investigated the effects of hyperthermia on the protect...

journal_title：Neurochemical research

authors： Du F,Qian ZM,Zhu L,Wu XM,Yung WH,Ke Y

更新日期：2011-02-01 00:00:00

abstract：:Protein misfolding and deposition in the brain are implicated in the etiology of numerous neurodegenerative disorders. Here, organic solutes characteristic of microorganisms adapted to hot environments, were tested on experimental cell models of Huntington's and Parkinson's diseases. Diglycerol phosphate, di-myo-inosi...

journal_title：Neurochemical research

authors： Jorge CD,Ventura R,Maycock C,Outeiro TF,Santos H,Costa J

更新日期：2011-06-01 00:00:00

abstract：:Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...

journal_title：Neurochemical research

authors： Grassi S,Giussani P,Prioni S,Button D,Cao J,Hakimi I,Sarmiere P,Srinivas M,Cabitta L,Sonnino S,Prinetti A

更新日期：2019-06-01 00:00:00

abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...

journal_title：Neurochemical research

authors： Long Y,Zhuang K,Ji Z,Han Y,Fei Y,Zheng W,Song Z,Yang H

更新日期：2019-04-01 00:00:00

abstract：:The effect of postdecapitative ischemia (5 min at 37 degrees) and hypoxia (5% O2, 95% N2, 30 min) on the distribution of protein radioactivity in the cellular fractions of guinea pig cerebral cortex was studied. Ischemic conditions resulted in the increase of total radioactivity level and protein content in the mitoch...

journal_title：Neurochemical research

authors： Rossowska M,Zalewska T

更新日期：1979-02-01 00:00:00

abstract：:TRH-like immunoreactivity distinct from TRH is present in various tissues and fluids. In order to determine whether TRH-like molecules are secreted by the hypothalamus, we analyzed tissues and media from hypothalamic slices incubated in Krebs Ringer bicarbonate. Media from basal or high KCl conditions contained 3 TRH-...

journal_title：Neurochemical research

authors： Méndez M,Cisneros M,Baez A,Joseph-Bravo P,Charli JL

更新日期：1999-07-01 00:00:00

abstract：:The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...

journal_title：Neurochemical research

authors： Cushman JD,Moore MD,Olsen RW,Fanselow MS

更新日期：2014-06-01 00:00:00

abstract：:It is reported that CNS hemorrhage causes membrane dysfunction and may exacerbate this damage as a result of secondary ischemia or hypoxia. Since hyperbaric oxygenation improves oxygen metabolism, it may reduce this membrane damage. The present study was conducted to reveal whether hyperbaric oxygenation influences me...

journal_title：Neurochemical research

authors： Yufu K,Itoh T,Edamatsu R,Mori A,Hirakawa M

更新日期：1993-09-01 00:00:00

abstract：:Epilepsy is one of the oldest neurological conditions known to humankind. It is known that oxidative stress and generation of reactive oxygen species are a cause and consequence of epileptic seizures. Although recent years have seen tremendous progress in the molecular biology and metabolism of selenium, we still know...

journal_title：Neurochemical research

authors： Nazıroglu M

更新日期：2009-12-01 00:00:00

abstract：:The effect of optic nerve transsection on proteolytic degradation of axonally transported proteins in the superior colliculus of the rabbit was studied. Proteolysis of labeled proteins was determined in vitro in small pieces of the superior colliculus. Within 2 hours after sectioning the optic nerve there was a decrea...

journal_title：Neurochemical research

authors： Gustavsson S,Karlsson JO

更新日期：1988-07-01 00:00:00

abstract：:We have previously shown that extracellular ATP caused cell death in PC12 cells through activation of its receptors. Oxidative stress has been implicated as a mechanism of cell death caused by extracellular ATP. In the present study we examined the possible signal transduction cascades leading to cell death by extrace...

journal_title：Neurochemical research

authors： Chen Y,Sun AY

更新日期：1998-04-01 00:00:00

abstract：:Evidence suggests that apoptosis contributes significantly to cell death after cerebral ischemia. Our recent studies that utilized human umbilical cord blood-derived mesenchymal stem cells (hUCBSCs) demonstrated the potential of hUCBSCs to inhibit neuronal apoptosis in a rat model of CNS injury. Therefore, we hypothes...

journal_title：Neurochemical research

authors： Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Veeravalli KK

更新日期：2014-08-01 00:00:00

abstract：:There is increasing evidence that proteins normally involved in the cell cycle play a role in the regulation of neuronal apoptotic death following various insults. However, it is not clear if the same mechanisms regulate cell death of oligodendrocytes as well. In this study, we investigated the mechanism of ceramide-i...

journal_title：Neurochemical research

authors： Strazza M,Luddi A,Brogi A,Carbone M,Riccio M,Santi S,Melli M,Costantino-Ceccarini E

更新日期：2004-05-01 00:00:00

abstract：:Malformations of cortical development (MCD) are critical brain development disorders associated with varied abnormalities in both anatomic structures and neural functioning. It is also a very common etiology to the epilepsy, in which the alteration on excitability of cortical neurons is hypothesized as one of importan...

journal_title：Neurochemical research

authors： Wang Y,Sun D,Yue Z,Tang W,Xiao B,Feng L

更新日期：2016-09-01 00:00:00