Abstract：
:Malformations of cortical development (MCD) are critical brain development disorders associated with varied abnormalities in both anatomic structures and neural functioning. It is also a very common etiology to the epilepsy, in which the alteration on excitability of cortical neurons is hypothesized as one of important causes to the epileptic seizures. Due to the key role in regulating neuron firing properties, the plasticity of axon initial segment (AIS) was investigated in present study to further determine the relation between MCD and epilepsy. Our results showed a prolonged decrease in the length of AIS occurred in MCD animal models. Besides, the AIS was also found greatly shortened in MCD models during the acute, but not chronic phase of status epileptics compared with intact controls. Our findings of identification of AIS plasticity in MCD animal models and its hypersensitivity to status epilepsy are significant in furthering our understanding of the pathophysiological mechanisms involved in this disorder.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Wang Y,Sun D,Yue Z,Tang W,Xiao B,Feng Ldoi
10.1007/s11064-016-1936-7subject
Has Abstractpub_date
2016-09-01 00:00:00pages
2215-22issue
9eissn
0364-3190issn
1573-6903pii
10.1007/s11064-016-1936-7journal_volume
41pub_type
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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更新日期：2013-03-01 00:00:00
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abstract：:Bovine brain synaptic membranes which were frozen and then extensively washed showed low affinity [3H]muscimol binding. These membranes contained GABA and calmodulin, apparently tightly bound within the membrane fraction. Membranes which were additionally treated with the detergent Triton X-100 showed high affinity [3...
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abstract：:A double ligand enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies against brain tissue antigens in the sera of patients with neurological diseases. The sera were tested on human white matter homogenate. The technique consists of successive incubations with the human serum to be tested, ...
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更新日期：1985-04-01 00:00:00
