Dose- and time-dependent hippocampal cholinergic lesions induced by ethylcholine mustard aziridinium ion: effects of nerve growth factor, GM1 ganglioside, and vitamin E.

abstract：:Probenecid inhibits the transport of the small monocarboxylic acids lactate and propionate from blood to brain but does not affect the transport of 5HIAA or HVA. Neither lactate, 5HIAA, HVA, nor probenecid itself inhibits probenecid uptake into brain from blood and neither lactate nor 5HIAA itself inhibits 5HIAA uptak...

journal_title：Neurochemical research

authors： Yuwiler A,Bennett BL,Geller E

更新日期：1982-10-01 00:00:00

abstract：:Harpagophytum procumbens, popularly known as devil's claw, is a plant commonly used in the treatment of diseases of inflammatory origin. The anti-inflammatory effects of H. procumbens have been studied; however, the mechanism of action is not elucidated. It is known that excess of reactive oxygen and nitrogen species ...

journal_title：Neurochemical research

authors： Schaffer LF,Peroza LR,Boligon AA,Athayde ML,Alves SH,Fachinetto R,Wagner C

更新日期：2013-11-01 00:00:00

abstract：:It has been reported that electrical stimulation (ES) can promote nerve regeneration. One of the key factors leading to the promotion is calcium, which plays a vital role in the regulation on electrical activity of neurons, but the detailed mechanism is still an open question. In this study, ES was used to stimulate c...

journal_title：Neurochemical research

authors： Yan X,Liu J,Huang J,Huang M,He F,Ye Z,Xiao W,Hu X,Luo Z

更新日期：2014-01-01 00:00:00

abstract：:Adult neural stem cells can be isolated from various regions of the rat brain and seem to have multilineage differentiation potential. In this study, we investigated the hypothesis that global protein expression of adult neural stem cells isolated from rat hippocampus is changed during in vitro differentiation. After ...

journal_title：Neurochemical research

authors： Maurer MH,Feldmann RE Jr,Fütterer CD,Butlin J,Kuschinsky W

更新日期：2004-06-01 00:00:00

abstract：:Cold restraint stress (CRS) model exerts similar effect as physiological stress because it combines emotional stress (escape reaction) and physical stress (muscle work). It is well established that various responses to stress are regulated by sympathoadrenal system, brain monoaminergic systems and oxidative processes....

journal_title：Neurochemical research

authors： Lyle N,Chakrabarti S,Sur T,Gomes A,Bhattacharyya D

更新日期：2012-12-01 00:00:00

abstract：:Cerebral blood flow (CBF) and cerebellar blood flow (CeBF) were measured and correlated with brain lactate, pyruvate and adenosine triphosphate concentrations from groups representing 3-week old suckling (n = 10), 18-22-week old adult (n = 9) and 70-week old aged (n = 7) Sprague-Dawley rats before and during bilateral...

journal_title：Neurochemical research

authors： He Z,Ibayashi S,Sugimori H,Fujii K,Sadoshima S,Fujishima M

更新日期：1997-01-01 00:00:00

abstract：:Ion channels are targets of various antiepileptic drugs. In cerebral presynaptic nerve endings Na(+) and Ca(2+) channels are particularly abundant, as they control neurotransmitter release, including the release of glutamate (Glu), the most concentrated excitatory amino acid neurotransmitter in the brain. Several pre-...

journal_title：Neurochemical research

authors： Sitges M,Chiu LM,Reed RC

更新日期：2016-04-01 00:00:00

abstract：:We have utilized quantitative autoradiography with the GABA(A) receptor chloride channel blocker [35S]t-butylbicyclophosphorothionate ([35S]TBPS) in rodent brain sections to investigate if differential proton modulation of various GABA(A) receptor subtypes expressed in various brain regions are differentially sensitiv...

journal_title：Neurochemical research

authors： Uusi-Oukari M,Kosonen P,Homanics GE,Korpi ER

更新日期：2004-04-01 00:00:00

abstract：:The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...

journal_title：Neurochemical research

authors： Saransaari P,Oja SS

更新日期：2008-03-01 00:00:00

abstract：:One pathway by which tryptophan is metabolized in the brain as well as in the periphery is through cleavage of the indole ring to formylkynurenine and then kynurenine. Indoleamine-2,3-dioxygenase, the enzyme that catalyzes this cleavage, and kynurenine are distributed all across the different anatomic regions of brain...

journal_title：Neurochemical research

authors： Gál EM,Sherman AD

更新日期：1980-03-01 00:00:00

abstract：:The effects of phenylalanine (PHE) and its deaminated metabolites phenylpyruvate (PHP), phenyllactate (PHL) and phenylacetate (PHA) on sodium and potassium activated adenosinetriphosphatase (Na+,K+-ATPase) in synaptosomes from rat brain were investigated. At very low concentrations (5-10 microM). PHE, PHL and PHA inhi...

journal_title：Neurochemical research

authors： Dwivedy AK,Shah SN

更新日期：1982-06-01 00:00:00

abstract：:The activation of caspase-3 is considered to be a reliable marker for apoptotic cell death, and a 120-kDa fragment of αII-spectrin is generated by caspase-3 mediated cleavage of this structural protein. In the present study, we compared cleaved αII-spectrin (120-kDa) and cleaved caspase-3-immunoreactive cells and thei...

journal_title：Neurochemical research

authors： Hwang IK,Ahn JH,Yoo DY,Lee CH,Yoo KY,Choi JH,Moon SM,Shin HC,Won MH

更新日期：2012-03-01 00:00:00

abstract：:McGill-R-Thy1-APP rats express the human amyloid precursor protein carrying the Swedish and Indiana mutations. We examined the neurochemical content of the dorsal hippocampus in three-months-old male and female transgenic rats and healthy age- and gender-matched controls using in vivo (1)H MRS in order to assess early...

journal_title：Neurochemical research

authors： Nilsen LH,Melø TM,Witter MP,Sonnewald U

更新日期：2014-02-01 00:00:00

abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...

journal_title：Neurochemical research

authors： Kim JS,Giacobini E

更新日期：1985-10-01 00:00:00

abstract：:Specific [3H]MK801 binding to rat brain NMDA receptors after the administration of the convulsant drug 3-mercaptopropionic acid (MP) and the adenosine analogue cyclopentyladenosine (CPA) was studied by means of a quantitative autoradiographic method. MP administration (150 mg/kg, i.p.) caused significant decreases in ...

journal_title：Neurochemical research

authors： Giraldez L,Girardi E

更新日期：1998-10-01 00:00:00

abstract：:This review presents data on metabotropic uridine nucleotide receptor subtypes (P2UR) activated by UTP, sometimes also by UDP and/or ATP. Some chemical details of receptor subtypes and ligand interactions are described. Ligand-activated P2UR subtypes may couple to different second messengers, yet little is known about...

journal_title：Neurochemical research

authors： Heilbronn E,Knoblauch BH,Müller CE

更新日期：1997-08-01 00:00:00

abstract：:Two major glycoproteins, P0 and PASII/PMP22, are specifically expressed in peripheral myelin. Point mutations of these proteins and over or under expression of PASII/PMP22 cause various hereditary peripheral neuropathies. P0 is well characterized as a major adhesion molecule in PNS myelin, but the function of PASII/PM...

journal_title：Neurochemical research

authors： Takeda Y,Notsu T,Kitamura K,Uyemura K

更新日期：2001-06-01 00:00:00

abstract：:Microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as Alzheimer disease. Mounting evidence points to ion channels expressed by microglia as contributing to these neuropathologies. The Chloride Intracellular Channel (CLIC) family represent...

journal_title：Neurochemical research

authors： Skaper SD,Facci L,Giusti P

更新日期：2013-09-01 00:00:00

abstract：:The effect of anticonvulsant drugs was examined on brain GABA levels and GAD and GABA-T activities. The level of GABA was increased by the treatment with diphenylhydantoin. The drug had no effect on GABA-T activity, whereas GAD activity was inhibited. Carbamazepine increased the GABA level but did not effect GAD and G...

journal_title：Neurochemical research

authors： Battistin L,Varotto M,Berlese G,Roman G

更新日期：1984-02-01 00:00:00

abstract：:Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervo...

journal_title：Neurochemical research

authors： Nieoczym D,Socała K,Wlaź P

更新日期：2018-05-01 00:00:00

abstract：:Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress....

journal_title：Neurochemical research

authors： Finamor IA,Ourique GM,Pês TS,Saccol EM,Bressan CA,Scheid T,Baldisserotto B,Llesuy SF,Partata WA,Pavanato MA

更新日期：2014-09-01 00:00:00

abstract：:Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles...

journal_title：Neurochemical research

authors： Shin EJ,Tran HQ,Nguyen PT,Jeong JH,Nah SY,Jang CG,Nabeshima T,Kim HC

更新日期：2018-01-01 00:00:00

abstract：:The kinetics and specificity of taurine and beta-alanine uptake were studied in primary cultures of rat astrocytes under identical experimental conditions. The uptake consisted of nonsaturable penetration and saturable high-affinity transport that was strictly sodium dependent. The cells accumulated taurine more effec...

journal_title：Neurochemical research

authors： Holopainen I,Kontro P

更新日期：1986-02-01 00:00:00

abstract：:Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...

journal_title：Neurochemical research

authors： Gong SJ,Chen LY,Zhang M,Gong JX,Ma YX,Zhang JM,Wang YJ,Hu YY,Sun XC,Li WB,Zhang Y

更新日期：2012-03-01 00:00:00

abstract：:Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippocampus and brainstem are involved in affective disorders. Sodium-potassium/ATPase is of paramount importance for the proper functioning of the brain and its involvement in the affective disorders has been claimed for a l...

journal_title：Neurochemical research

authors： Bignotto M,Benedito MA

更新日期：2006-04-01 00:00:00

abstract：:A phosphoinositide-linked peptide response in cultured rat astrocytes was studied by measuring the accumulation of [3H]inositol phosphates in the presence of lithium. Cultures derived from cortex, cerebellum and spinal cord each showed a unique pattern or degree of stimulation to a panel of neuropeptides. Cortical and...

journal_title：Neurochemical research

authors： Cholewinski AJ,Hanley MR,Wilkin GP

更新日期：1988-04-01 00:00:00

abstract：:MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is invol...

journal_title：Neurochemical research

authors： Ji W,Jiao J,Cheng C,Shao J

更新日期：2018-10-01 00:00:00

abstract：:Radioactive 125I seeds-based radiotherapy has achieved great success in treatment of human cancers. However, radioresistance and severe side effects badly limited its clinic application. Recently, chemoradiotherapy as a superior strategy has been rapidly developed and widely used in clinic. However, the underlying mec...

journal_title：Neurochemical research

authors： Liu C,Wang L,Qiu H,Dong Q,Feng Y,Li D,Li C,Fan C

更新日期：2018-07-01 00:00:00

abstract：:Analysis in mouse brain slices of the uptake of acetyl-L-[N-methyl-14C]carnitine with time showed it to be concentrative, and kinetic analysis gave a Km of 1.92 mM and a Vmax of 1.96 mumol/min per ml, indicating the presence of a low-affinity carrier system. The uptake was energy-requiring and sodium-dependent, being ...

journal_title：Neurochemical research

authors： Burlina AP,Sershen H,Debler EA,Lajtha A

更新日期：1989-05-01 00:00:00

abstract：:The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...

journal_title：Neurochemical research

authors： Alshuaib WB,Mathew MV

更新日期：2005-09-01 00:00:00