Intermittent hypobaric hypoxia preconditioning induced brain ischemic tolerance by up-regulating glial glutamate transporter-1 in rats.

abstract：:Correct timing and spatial location of growth factor expression is critical for undisturbed brain development and functioning. In terminally differentiated cells distinct biological responses to growth factors may depend on cell type specific activation of signalling cascades. We show that the hematopoietic growth fac...

journal_title：Neurochemical research

authors： Byts N,Samoylenko A,Woldt H,Ehrenreich H,Sirén AL

更新日期：2006-10-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) and Schwann cells (SCs) are closely-related cell types with regeneration-promoting properties. Comparative gene expression analysis is particularly relevant since it may explain cell type-specific effects and guide the use of each cell type into special clinical applications. In the ...

journal_title：Neurochemical research

authors： Omar M,Hansmann F,Kreutzer R,Kreutzer M,Brandes G,Wewetzer K

更新日期：2013-05-01 00:00:00

abstract：:Several lines of evidence suggest that the mechanism underlying drug-induced neuronal apoptosis is initiated by the increased production of reactive oxygen species (ROS). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin, has been shown to initiate an apoptotic cascade by increasing ROS in the dopamine...

journal_title：Neurochemical research

authors： Nopparat C,Porter JE,Ebadi M,Govitrapong P

更新日期：2014-02-01 00:00:00

abstract：:Secretases degrade amyloid precursor protein (APP) releasing fragments (beta-peptides A beta, A beta x) that assemble to form hallmark extracellular deposits in Alzheimer's disease (AD) correlating with disease severity. As such, secretases supply targets for therapeutic intervention and form the focus of this overvie...

journal_title：Neurochemical research

authors： Marks N,Berg MJ

更新日期：2003-07-01 00:00:00

abstract：:Adult neural stem cells can be isolated from various regions of the rat brain and seem to have multilineage differentiation potential. In this study, we investigated the hypothesis that global protein expression of adult neural stem cells isolated from rat hippocampus is changed during in vitro differentiation. After ...

journal_title：Neurochemical research

authors： Maurer MH,Feldmann RE Jr,Fütterer CD,Butlin J,Kuschinsky W

更新日期：2004-06-01 00:00:00

abstract：:In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongat...

journal_title：Neurochemical research

authors： Manukian KH,Kirakosian LG

更新日期：1985-11-01 00:00:00

abstract：:The activities of L-glutamate decarboxylase (GAD), GABA-transaminase (GABA-T), choline acetyltransferase (CAT), and cysteic and cysteinesulfinic acids decarboxylase (CAD/CSAD) in putamen and frontal cortex in both Huntington's chorea and normal tissues were measured. The greatest difference between Huntington's and no...

journal_title：Neurochemical research

authors： Wu JY,Bird ED,Chen MS,Huang WM

更新日期：1979-10-01 00:00:00

abstract：:Oxidative stress is known to induce cell death in a wide variety of cell types, apparently by modulating intracellular signaling pathways. Activation of extracellular signal-regulated kinase (ERK) in oxidative stress remains controversial. In some cellular systems, the ERK activation is associated with protection agai...

journal_title：Neurochemical research

authors： Lee WC,Choi CH,Cha SH,Oh HL,Kim- YK

更新日期：2005-02-01 00:00:00

abstract：:To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...

journal_title：Neurochemical research

authors： Tanaka K,Asanuma M,Ogawa N

更新日期：2004-08-01 00:00:00

abstract：:Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippocampus and brainstem are involved in affective disorders. Sodium-potassium/ATPase is of paramount importance for the proper functioning of the brain and its involvement in the affective disorders has been claimed for a l...

journal_title：Neurochemical research

authors： Bignotto M,Benedito MA

更新日期：2006-04-01 00:00:00

abstract：:The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...

journal_title：Neurochemical research

authors： Dewar KM,Dyck LE,Durden DA,Boulton AA

更新日期：1988-02-01 00:00:00

abstract：:The influence of theophylline (2.5--100 mg/kg p.o.) on cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) in brain of Sprague-Dawley rats (0.5--3.0 hr after administration of theophylline) was investigated. It was found that theophylline increases cAMP and cGMP levels when admi...

journal_title：Neurochemical research

authors： Stefanovich V

更新日期：1979-10-01 00:00:00

abstract：:The ability of Sendai virosomes or Lipofectin to introduce an AAV vector into primary rat brain astroglial cultures was characterized. The pJDT95npy vector was constructed by inserting rat NPY cDNA downstream from the indigenous AAV p5, p19 and p40 promoters in pJDT95. Lipofectin-mediated transfection with pJDT95npy (...

journal_title：Neurochemical research

authors： de Fiebre CM,Wu P,Notabartolo D,Millard WJ,Meyer EM

更新日期：1994-06-01 00:00:00

abstract：:We investigated the action of the new hypothalamic proline-rich peptide (PRP-1), normally produced by neurosecretory cells of hypothalamic nuclei (NPV and NSO), 3 and 4 weeks following rat sciatic nerve transection. The impulse activity flow of interneurons (IN) and motoneurons (MN) on stimulation of mixed (n. ischiad...

journal_title：Neurochemical research

authors： Galoyan AA,Sarkissian JS,Sulkhanyan RM,Chavushyan VA,Avetisyan ZA,Avakyan ZE,Gevorgyan AJ,Abrahamyan DO,Grigorian YKh

更新日期：2005-04-01 00:00:00

abstract：:The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease the Km for acetylthiocholine, without changes in Vmas. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity...

journal_title：Neurochemical research

authors： Pastuszko A

更新日期：1980-07-01 00:00:00

abstract：:During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...

journal_title：Neurochemical research

authors： Brown CH,Brunton PJ,Russell JA

更新日期：2008-04-01 00:00:00

abstract：:Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...

journal_title：Neurochemical research

authors： Goldberg WJ,Watson BD,Busto R,Kurchner H,Santiso M,Ginsberg MD

更新日期：1984-12-01 00:00:00

abstract：:Selective and limited proteolysis is a key step in the post-translational modification of peptide hormone precursors. This process appears to involve a proteolytic machinery including highly specific endoproteases. Some of the enzyme systems possibly involved in the processing of pro-neuropeptides will be described an...

journal_title：Neurochemical research

authors： Gluschankof P,Cohen P

更新日期：1987-10-01 00:00:00

abstract：:Apoptosis is a highly complex form of cell death that can be triggered by alterations in Ca(2+) homeostasis. Members of the Bcl-2 family may regulate apoptosis and modulate Ca(2+) distribution within intracellular compartments. Bax, a proapoptotic member of the family, is constitutively expressed and soluble in the cy...

journal_title：Neurochemical research

authors： Morales AP,Carvalho AC,Monteforte PT,Hirata H,Han SW,Hsu YT,Smaili SS

更新日期：2011-05-01 00:00:00

abstract：:The activity of gamma-glutamyltransferase localized in isolated brain synaptic membranes- and microvessels-enriched fractions was assayed after treatment of rats with either phenobarbital or ethanol. Phenobarbital increased the activity of gamma-glutamyltransferase in microvessels, without alteration of synaptic membr...

journal_title：Neurochemical research

authors： Ghersi-Egea JF,Minn A,Siest G

更新日期：1987-04-01 00:00:00

abstract：:Nitric oxide has been strongly implicated in the development of tissue infarction in response to focal cerebral ischemia. Nitric oxide and its derivatives can inhibit components of the electron transport chain, providing a likely target for these substances in ischemic and post-ischemic brain. Lactate content is incre...

journal_title：Neurochemical research

authors： Helps SC,Sims NR

更新日期：2007-04-01 00:00:00

abstract：:Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) receptors. There are eight known mGlu receptor subtypes (mGlu1-8), which are widely expressed throughout the brain, and are divided into three group...

journal_title：Neurochemical research

authors： Mercier MS,Lodge D

更新日期：2014-10-01 00:00:00

abstract：:The wobbler mouse suffers an autosomal recessive mutation producing severe neurodegeneration and astrogliosis in spinal cord. It has been considered a model for amyotrophic lateral sclerosis. We have studied in these animals the expression of two proteins, the growth-associated protein (GAP-43) and the NADPH-diaphoras...

journal_title：Neurochemical research

authors： González Deniselle MC,González SL,Lima AE,Wilkin G,De Nicola AF

更新日期：1999-01-01 00:00:00

abstract：:Cholinergic muscarinic receptors, when stimulated by arecoline, can activate cytosolic phospholipase A(2) (cPLA(2)) to release arachidonic acid (AA) from membrane phospholipid. This signal can be imaged in the brain in vivo using quantitative autoradiography following the intravenous injection of radiolabeled AA, as a...

journal_title：Neurochemical research

authors： Basselin M,Villacreses NE,Lee HJ,Bell JM,Rapoport SI

更新日期：2007-11-01 00:00:00

abstract：:Apoptosis can be defined as the regulated death of a cell and is conducted by conserved pathways. Apoptosis of neurons after injury or disease differs from programed cell death, in the sense that neurons in an adult brain are not "meant" to die and results in a loss of function. Thus apoptosis is an honorable process ...

journal_title：Neurochemical research

authors： Haeberlein SL

更新日期：2004-03-01 00:00:00

abstract：:Endoplasmic reticulum (ER) and mitochondria are intracellular organelles and their interactions are directly involved in different processes such as Ca(2+) signaling in cell survival and death mechanisms. Bcl-2 is an anti-apoptotic protein intrinsically related to ER and mitochondria, modulating Ca(2+) content in thes...

journal_title：Neurochemical research

authors： Hirata H,Lopes GS,Jurkiewicz A,Garcez-do-Carmo L,Smaili SS

更新日期：2012-02-01 00:00:00

abstract：:The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration ...

journal_title：Neurochemical research

authors： Lakshmi S,Essa MM,Hartman RE,Guillemin GJ,Sivan S,Elumalai P

更新日期：2020-11-01 00:00:00

abstract：:The present study addressed the hypothesis that the DA transporter ligand, [3H]mazindol, labels multiple sites/states associated with the dopamine (DA) transporter in striatal membranes. Incubations with [3H]mazindol proceeded for 18-24 hr at 4 degrees C in 55.2 mM sodium phosphate buffer, pH 7.4, with a protease inhi...

journal_title：Neurochemical research

authors： Dersch CM,Akunne HC,Partilla JS,Char GU,de Costa BR,Rice KC,Carroll FI,Rothman RB

更新日期：1994-02-01 00:00:00

abstract：:We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-family member thioredoxin (THX), and asked whether changes in PDI/THX were associated with production of oxidative/nitro...

journal_title：Neurochemical research

authors： Tshala-Katumbay D,Desjardins P,Sabri M,Butterworth R,Spencer P

更新日期：2009-11-01 00:00:00

abstract：:Deprenyl has been discovered by Knoll and co-workers. The R-enantiomer of deprenyl (selegiline) is a selective and irreversible inhibitor of the B-isoform of monoamine oxidase (MAO-B) enzyme. Due to its dopamine potentiating and possible neuroprotective properties it has an established role in the treatment of parkins...

journal_title：Neurochemical research

authors： Magyar K,Szende B,Jenei V,Tábi T,Pálfi M,Szöko E

更新日期：2010-12-01 00:00:00