Abstract:
:The influence of theophylline (2.5--100 mg/kg p.o.) on cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) in brain of Sprague-Dawley rats (0.5--3.0 hr after administration of theophylline) was investigated. It was found that theophylline increases cAMP and cGMP levels when administered in a dose of 25 mg/kg or higher. A significant decrease of cGMP level was observed after administration of 10 mg/kg. The results of this study suggest that the influence of theophylline on cyclic nucleotide levels of rat brain is the result of two factors: (a) inhibitory properties of theophylline on cAMP and cGMP phosphodiesterases and (b) competition of theophylline with adenosine.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Stefanovich Vdoi
10.1007/BF00964436subject
Has Abstractpub_date
1979-10-01 00:00:00pages
587-94issue
5eissn
0364-3190issn
1573-6903journal_volume
4pub_type
杂志文章abstract::Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02733-4
更新日期:2019-04-01 00:00:00
abstract::The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-9032-4
更新日期:2006-03-01 00:00:00
abstract::Complementary DNA (cDNA) clones containing the entire coding sequence for Diazepam Binding Inhibitor (DBI) peptide, a 10-kDa precursor of putative natural ligands of benzodiazepine recognition sites, were isolated from rat, human and cow libraries. The sequence of all these clones is highly conserved; however, the N-t...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF00972202
更新日期:1990-02-01 00:00:00
abstract::Chlorpyrifos (CPF), an organophosphorus insecticide is known to cause ill health in non-target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-related differences and vulnerability in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0311-3
更新日期:2011-02-01 00:00:00
abstract::We previously showed that extracellular levels of N-acetylaspartate (NAA) increase when a medium with reduced NaCl concentration is perfused through a microdialysis probe, and proposed that NAA may be released during hypoosmotic swelling. Here, we demonstrate that this effect is due to hypoosmolarity of the perfusion ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020778832745
更新日期:1998-08-01 00:00:00
abstract::We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007546600535
更新日期:2000-05-01 00:00:00
abstract::Subunit-specific antibodies to all the gamma subunit isoforms described in mammalian brain (gamma(1), gamma(2S), gamma(2L), and gamma(3) have been made. The proportion of GABA(A) receptors containing each gamma subunit isoform in various brain regions has been determined by quantitative immunoprecipitation. In all tes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02529132
更新日期:1996-02-01 00:00:00
abstract::Excitatory and inhibitory neurotransmission in the central nervous system can be modulated by neurosteroids. We previously found that in rat hippocampal slices allopregnanolone (3α-hydroxy-5α-pregnan-20-one), a positive GABA(A) receptor modulator, suppresses the epileptic discharges induced by 4-aminopyridine (4-AP), ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0649-1
更新日期:2012-03-01 00:00:00
abstract:UNLABELLED:Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0788-z
更新日期:2012-08-01 00:00:00
abstract::We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1010999622760
更新日期:2001-06-01 00:00:00
abstract::Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMD...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9213-9
更新日期:2007-02-01 00:00:00
abstract::Cortical spreading depression (CSD) enhances ischemic tolerance to temporary focal ischemia. Although this effect most likely requires the expression or activation of neuroprotective factors, their identity remains relatively unknown. One important factor involved in neuroprotection is adenosine monophosphate-dependen...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1447-3
更新日期:2014-12-01 00:00:00
abstract::Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0229-9
更新日期:2010-11-01 00:00:00
abstract::Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965929
更新日期:1989-10-01 00:00:00
abstract::Pig brain cerebral cortex was subfractionated by isopycnic centrifugation in sucrose gradients. In each subfraction the content of the agonist [3H]R-PIA binding, the activity of adenosine metabolizing enzymes (5'-nucleotidase and adenosine deaminase) and the activity of membrane marker enzymes were determined. The fra...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966790
更新日期:1992-02-01 00:00:00
abstract::Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the crit...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022075508176
更新日期:1997-07-01 00:00:00
abstract::Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2701-x
更新日期:2019-06-01 00:00:00
abstract::During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering multiple cellular responses to injury. Here, we evaluated changes in extracellular ATP, ADP and AMP hydrolysis at different times (0-24 hours) after unilateral cortical stab injury (CSI) in adul...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9529-0
更新日期:2008-05-01 00:00:00
abstract::The long-acting opiate antagonist naltrexone hydrochloride was administered by intraperitoneal injection, in a dose response protocol, to adult rats. The drug was used to observe effects of opiate receptor blockade on cells of the pituitary gland and adjacent hypothalamus. At higher drug doses (5 mg/kg or 10 mg/kg), n...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964168
更新日期:1984-02-01 00:00:00
abstract::Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 microM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates ge...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9608-x
更新日期:2008-09-01 00:00:00
abstract::Harpagophytum procumbens, popularly known as devil's claw, is a plant commonly used in the treatment of diseases of inflammatory origin. The anti-inflammatory effects of H. procumbens have been studied; however, the mechanism of action is not elucidated. It is known that excess of reactive oxygen and nitrogen species ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1133-x
更新日期:2013-11-01 00:00:00
abstract::The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undert...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02839-9
更新日期:2019-08-01 00:00:00
abstract::Dual-specificity tyrosine-regulated kinase 2 (DYRK2), a protein kinase that phosphorylates its substrates on serine/threonine, is expressed in numerous human tumors, but little is known about its role in the pathophysiology of glioma. In this study, we made an effort to explore the expression and function in human gli...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2345-2
更新日期:2017-11-01 00:00:00
abstract::CNTF (ciliary neurotrophic factor) has been suggested to be an important survival factor for oligodendrocytes; however, this effect is inconsistently obtained and myelination appears normal in CNTF null animals. On the other hand, CNTF stimulates astrocytes to produce growth and trophic factors. Therefore, we tested t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9151-6
更新日期:2007-02-01 00:00:00
abstract::The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-7412-4
更新日期:2005-09-01 00:00:00
abstract::The real-time iontophoretic method has measured volume fraction and tortuosity of the interstitial component of extracellular space in many regions and under different conditions. To interpret these data computer models of the interstitial space (ISS) of the brain are constructed by representing cells as Basic Cellula...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02793-6
更新日期:2020-01-01 00:00:00
abstract::Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In o...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9629-5
更新日期:2008-09-01 00:00:00
abstract::Our previous studies have shown that three sigma (sigma) receptor ligands, (+)-N-allylnormetazocine ((+)-SKF-10,047), (+/-)-pentazocine and 1,3-di(2-tolyl)guanidine (DTG) differently regulated the dopamine (DA) transmission in the rat brain. In the present study, we attempted to clarify the role of sigma 1 receptor su...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1027361101419
更新日期:1997-09-01 00:00:00
abstract::Amyloidogenic proteins (Abeta peptide) in Alzheimer's disease (AD) and alpha-synuclein (alpha-Syn) in Parkinson's disease (PD) are typically soluble monomeric precursors, which undergo remarkable conformational changes and culminate in the form of aggregates in diseased condition. Overlap of clinical and neuropatholog...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9140-9
更新日期:2006-09-01 00:00:00
abstract::Patients with diabetes display a progressive decay in the physiological counter-regulatory response to hypoglycemia, resulting in hypoglycemia unawareness. The mechanism through which the brain adapts to hypoglycemia may involve brain glycogen. We tested the hypothesis that brain glycogen supercompensation following h...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2178-z
更新日期:2017-06-01 00:00:00