Abstract:
:Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the critical period for the anatomical plasticity observed in layer IV barrel neuron is not clear yet, the accumulating evidence suggests that neurotrophins modulate synaptic connections including central nervous system. In this study, we showed by in situ hybridization that mouse barrel side neurons express brain-derived neurotrophic factor (BDNF) mRNA and both catalytic and non-catalytic forms of trkB mRNA. Cautery of row C vibrissae on the right side of the face within 24 h after birth (post natal day 0, PND0) reduced the expression of BDNF and trkB mRNA from the division region between the contralateral row C barrels at PND7. The vibrissae in row A, C, and E were cauterized at PND0 followed by quantitative RT-PCR for BDNF and trkB mRNA with total RNA isolated from the barrel region at PND7. The result showed that BDNF, but not trkB, mRNA was increased several-fold in the contralateral barrel region. These data suggest that the expression of BDNF mRNA is differentially regulated between injured barrels and actively innervated barrels. The differential expression of the mRNA encoding neurotrophins and their receptors may be important in regulating the injury-dependent re-segregation of barrels.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Singh TD,Mizuno K,Kohno T,Nakamura Sdoi
10.1023/a:1022075508176subject
Has Abstractpub_date
1997-07-01 00:00:00pages
791-7issue
7eissn
0364-3190issn
1573-6903journal_volume
22pub_type
杂志文章abstract::Brains of Alzheimer disease patients in early stages of dementia contain an increased 24(S)-hydroxycholesterol (cerebrosterol)/cholesterol ratio when compared to controls. In this study, effects of amyloid beta peptides and of racemic 24-hydroxycholesterol were evaluated in vitro on undepleted or cholesterol-depleted ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9443-5
更新日期:2008-03-01 00:00:00
abstract::During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9506-7
更新日期:2008-04-01 00:00:00
abstract::Pyroptosis is a newly identified lytic form of programmed cell death which is characterized by plasma membrane blebbing and rupture. Pyroptosis occurs in cerebral ischemia injury, and contributes to the activation and secretion of the inflammatory cytokines interleukin (IL)-1β, IL-18, and IL-6. Previous reports have f...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02935-w
更新日期:2020-02-01 00:00:00
abstract::The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9439-1
更新日期:2008-03-01 00:00:00
abstract::The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebe...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1027345808746
更新日期:1997-06-01 00:00:00
abstract::Adult neural stem cells can be isolated from various regions of the rat brain and seem to have multilineage differentiation potential. In this study, we investigated the hypothesis that global protein expression of adult neural stem cells isolated from rat hippocampus is changed during in vitro differentiation. After ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000023600.25994.11
更新日期:2004-06-01 00:00:00
abstract::Previous studies have shown that chronic administration of SR-3 (a 1:4 mixture of alpha-linolenic and linoleic acid) affects spatial learning, thermoregulation, pain threshold and protection from seizures. The mode of action is unknown. One possible explanation is that the preparation induces changes in the fatty acid...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022430620205
更新日期:1998-05-01 00:00:00
abstract::Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators are ADP and leucine and inhibitors include GTP, p...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-013-1173-2
更新日期:2014-01-01 00:00:00
abstract::Spinal cord injury (SCI), a severe health problem in worldwide, was commonly associated with functional disability and reduced quality of life. As the expression of brain-derived neurotrophic factor (BDNF) was substantial event in injured spinal cord, we hypothesized whether BDNF-overexpression could be in favor of th...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1970-5
更新日期:2016-10-01 00:00:00
abstract::The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-7412-4
更新日期:2005-09-01 00:00:00
abstract::The pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood-brain barrier (BBB) disruption has been indicated among the possible causative mechanisms. S100B, a calcium binding protein, originates in the central nervous system but it can be also produced by extra-cerebral sources; it is passi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9907-2
更新日期:2009-07-01 00:00:00
abstract::Lipid synthesis from acetoacetate and 3-hydroxybutyrate was studied in chick embryo from 15 to 21 days and in chick neonate from 1 to 21 days. Embryonic spinal cord showed higher ability than brain to incorporate acetoacetate into total lipids, although a sharp decrease was found at hatching. 3-Hydroxybutyrate incorpo...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966692
更新日期:1993-10-01 00:00:00
abstract::Exposure of rat pheochromocytoma PC12 cells to 0.1 mM 6-aminonicotinamide (6AN) for 24 hours resulted in a 500-fold increase in 6-phosphogluconate indicating active metabolism of glucose via the oxidative enzymes of the pentose phosphate pathway. Amounts of 6-phosphogluconate that accumulated in 6AN-treated cells at 2...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01000236
更新日期:1987-06-01 00:00:00
abstract::Ketogenic diet (KD) has been shown to be beneficial in a range of neurological disorders, with ketone metabolite β-hydroxybutyrate (βOHB) reported to block the nucleotide oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in bone marrow-derived macrophages. In this study, we sh...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03156-2
更新日期:2020-10-27 00:00:00
abstract::Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were adminis...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03174-0
更新日期:2020-11-17 00:00:00
abstract::Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital. Isobolographic analysi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1812-x
更新日期:2016-05-01 00:00:00
abstract::Ion fluxes in mammalian myelinated axons are restricted to the nodes of Ranvier, where, in particular, voltage-gated Na+ channels are clustered at a high density. The node of Ranvier is separated from the internode by two distinct domains of the axolemma, the paranode and the juxtaparanode. Each axonal domain is chara...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021608514646
更新日期:2003-01-01 00:00:00
abstract::We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF02527711
更新日期:1996-04-01 00:00:00
abstract::Rabbits sensitized with whole nervous tissue or myelin basic protein (MBP) plus adjuvant and developing experimental allergic encephalomyelitis (EAE) were studied for the presence of oligoclonal immunoglobulin (Ig) bands in spinal fluid and serum. Samples obtained prior to sensitization and at the time of sacrifice we...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00963909
更新日期:1981-01-01 00:00:00
abstract::Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2701-x
更新日期:2019-06-01 00:00:00
abstract::It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020937728506
更新日期:2002-10-01 00:00:00
abstract::Berberine and palmatine exhibit a mild and competitive inhibition on bovine adrenal tyrosine hydroxylase (EC 1.14.16.2; TH). In this study, the inhibitory effects of protoberberine alkaloids (such as berberine, palmatine and coptisine) on dopamine biosynthesis in PC12 cells were investigated. Treatment with berberine ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007541020736
更新日期:2000-03-01 00:00:00
abstract::The current studies focus on what mechanisms regulate the concentration of PLP mRNA in cells. The PLP mRNA is very stable and these studies suggest that its stability is regulated by a trans-acting factor specific to oligodendrocytes. In order to test whether the 3'untranslated region (3'UTR) of the PLP mRNA might reg...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021623700009
更新日期:2002-11-01 00:00:00
abstract::The monoclonal antibody 14E immunocytochemically stains the nuclear membrane of oligodendrocytes but not myelin in tissue sections of adult normal human white matter. The nuclear membranes of Schwann cells in human peripheral nerve and cerebellar Bergmann glia were also visualized with this antibody. In actively demye...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00993270
更新日期:1992-09-01 00:00:00
abstract::The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was fou...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1012372115058
更新日期:2001-09-01 00:00:00
abstract::An analytical method for the determination of saturated very long chain (VLC) fatty acids in the serum has been devised. Free fatty acids obtained after hydrolysis of total lipid extracts were converted into p-bromophenacyl esters. The derivatives were purified in two sequential steps by clean-up on C18 reversed-phase...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968082
更新日期:1984-12-01 00:00:00
abstract::The abnormal production of short chain fatty acid (SCFAs) caused by gut microbial dysbiosis plays an important role in the pathogenesis and progression of Parkinson's disease (PD). This study sought to evaluate how butyrate, one of SCFAs, affect the pathology in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03074-3
更新日期:2020-09-01 00:00:00
abstract::Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964958
更新日期:1980-12-01 00:00:00
abstract::The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0412-7
更新日期:2011-05-01 00:00:00
abstract::We examined the effects of small unilamellar vesicles composed of dipalmitoylphosphatidylcholine on rat cerebral cortical [3H]acetylcholine release. Synaptosomes from this region were loaded with the labeled transmitter, and then incubated with the lipid (0-6 mg/ml) for specified intervals before adding various secret...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00970530
更新日期:1987-08-01 00:00:00