Abstract：
:The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebellar Bergmann cells. Glu, NMDA, AMPA and KA evoked a dose and time dependent increase in MAPK activity. AMPA and KA responses were blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) whereas NMDA responses were sensitive to 3-[(RS)-2-carboxypiperazin-4-yl)]-propyl-1-phosphonate (CPP) indicating that the increase in MAPK activity is mediated by AMPA/low affinity KA and NMDA subtypes of Glu receptors. The present findings open the possibility of a MAPK cascade involvement in the regulation of Glu-induced gene expression in radial glia.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
López-Colomé AM,Ortega Adoi
10.1023/a:1027345808746subject
Has Abstractpub_date
1997-06-01 00:00:00pages
679-85issue
6eissn
0364-3190issn
1573-6903journal_volume
22pub_type
杂志文章abstract：:Cerebral deposition of amyloid β-peptide (Aβ), a fundamental feature of Alzheimer's disease (AD), damages the neurocytes and impairs the cognition functions and associative learning memory of AD patients. A series of novel 2-arylethenylquinoline derivatives were synthesized and evaluated in our previous study, which i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2339-0
更新日期：2017-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022418231496
更新日期：1998-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971579
更新日期：1994-03-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02533102
更新日期：1996-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027366413289
更新日期：1997-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000018859.23881.f9
更新日期：2004-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963858
更新日期：1981-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9177-9
更新日期：2006-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964058
更新日期：1978-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11064-009-9969-9
更新日期：2009-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2477-z
更新日期：2018-03-01 00:00:00
abstract：:The kinetics of the uptake of p-tyramine, m-tyramine, and dopamine were investigated in slices of the hypothalamus and striatum of the rat in the presence of nialamide. When uptake was analyzed by a least-squares fit to a Lineweaver-Burk plot, each amine appeared to be concentrated by both a "low"-affinity and a "high...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964440
更新日期：1979-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9246-0
更新日期：2007-03-01 00:00:00
abstract：:The ketone body, β-hydroxybutyrate (βOHB), is metabolised by the brain alongside the mandatory brain fuel glucose. To examine the extent and circumstances by which βOHB can supplement glucose metabolism, we studied guinea pig cortical brain slices using increasing concentrations of [U-13C]D-βOHB in conjunction with [1...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2228-6
更新日期：2017-06-01 00:00:00
abstract：:Two models of perturbed cerebellar ontogenesis were obtained by a single administration of methylazoxymethanol (MAM), a potent antimitotic agent, to mouse pups either on the day of birth (MAM0 mice) or at postnatal day 5 (MAM5 mice). The alterations of the cerebellar GABAergic system were studied by measuring glutamic...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968010
更新日期：1992-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965516
更新日期：1989-12-01 00:00:00
abstract：:Selective blockade of a subset of GABA(A) receptors may be involved in the antipsychotic effects of Clozapine and several other antipsychotic drugs. Seven antipsychotic drugs, and 11 drugs classified as antidepressants that only partially reverse the inhibitory effect of 1 microM GABA on [35S]TBPS binding, do not yiel...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027359422433
更新日期：1997-02-01 00:00:00
abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1863-7
更新日期：2016-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1305-3
更新日期：2014-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1670-6
更新日期：2015-09-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964640
更新日期：1979-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021052725921
更新日期：1999-08-01 00:00:00
abstract：:Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for ty...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0433-2
更新日期：2011-09-01 00:00:00
abstract：:The aim of this study was to investigate potential therapeutic effects of IFN-γ primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs) transplantation on experimental autoimmune encephalomyelitis (EAE) in mice. In this study, EAE mouse model was established by MOG35-55 immunization method. Outcomes of the E...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03009-y
更新日期：2020-07-01 00:00:00
abstract：:The labeling of RNA in young and adult rat brain has been studied by measuring in vitro (tissue slices incubation) the incorporation of labeled uridine into RNA of total tissue and of the various subcellular fractions purified from cerebral hemispheres of 1- and 10-month-old rats. Gel electrophoretic analysis of the n...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965100
更新日期：1983-04-01 00:00:00
abstract：:Anesthetics such as propofol can provide neuroprotective effects against cerebral ischemia. However, the underlying mechanism of this beneficial effect is not clear. Therefore, we subjected male Sprague-Dawley rats to 2 h of middle cerebral artery occlusion and investigated how post-ischemic administration of propofol...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0945-4
更新日期：2013-03-01 00:00:00
abstract：: ...
journal_title：Neurochemical research
pub_type： 传,社论,历史文章
doi：10.1007/s11064-018-02702-3
更新日期：2019-01-01 00:00:00
abstract：:A sensitive and rapid assay method method for cysteic acid decarboxylase was develped which combined the selectivity of ion exchange resin (a complete retention of the substrate, cysteic acid, and exclusion of the product, taurine) with the speed of a vacuum filtration. The synthesis and purification of 35S-labeled cy...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964144
更新日期：1979-04-01 00:00:00
abstract：:Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the crit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022075508176
更新日期：1997-07-01 00:00:00
abstract：:The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a common precursor, prosaposin. Saposins share several structural properties, including six similarly located cysteines forming three disulfide bridges with the s...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022530508763
更新日期：1999-02-01 00:00:00
