Effect of Imipramine, Paroxetine, and Lithium Carbonate on Neurobehavioral Changes of Streptozotocin in Rats: Impact on Glycogen Synthase Kinase-3 and Blood Glucose Level.

abstract：:Anesthetics such as propofol can provide neuroprotective effects against cerebral ischemia. However, the underlying mechanism of this beneficial effect is not clear. Therefore, we subjected male Sprague-Dawley rats to 2 h of middle cerebral artery occlusion and investigated how post-ischemic administration of propofol...

journal_title：Neurochemical research

authors： Zhao XC,Zhang LM,Tong DY,An P,Jiang C,Zhao P,Chen WM,Wang J

更新日期：2013-03-01 00:00:00

abstract：:The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decr...

journal_title：Neurochemical research

authors： Glaser J,Russell VA,de Villiers AS,Searson JA,Taljaard JJ

更新日期：1990-10-01 00:00:00

abstract：:The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968. The characteristic feature of aging com...

journal_title：Neurochemical research

authors： Takeda T

更新日期：2009-04-01 00:00:00

abstract：:Several methods have been described previously for the purification of the nervous-tissue specific protein kinase C substrate B-50 (GAP-43). In this paper we present a new purification method for B-50 from rat brain which employs 2-mercaptoethanol to release the protein from isolated synaptosomal plasma membranes. Mos...

journal_title：Neurochemical research

authors： De Graan PN,Moritz A,de Wit M,Gispen WH

更新日期：1993-08-01 00:00:00

abstract：:Apoptosis is a highly complex form of cell death that can be triggered by alterations in Ca(2+) homeostasis. Members of the Bcl-2 family may regulate apoptosis and modulate Ca(2+) distribution within intracellular compartments. Bax, a proapoptotic member of the family, is constitutively expressed and soluble in the cy...

journal_title：Neurochemical research

authors： Morales AP,Carvalho AC,Monteforte PT,Hirata H,Han SW,Hsu YT,Smaili SS

更新日期：2011-05-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) inhibits carbachol-stimulated phosphoinositide breakdown in rat brain cortical slices but not in isolated membranes (1). To gain insight into the mechanisms, we examined the effects of NMDA on carbachol-stimulated [3H]inositol phosphate and intermediates of phosphatidylinositol cycle accumu...

journal_title：Neurochemical research

authors： Lee HM,Huang CL

更新日期：1997-05-01 00:00:00

abstract：:Beta-amyloid (Abeta) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Abeta on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Abeta(25-35) at 3 and 10 microM for 12 and 24 h followed by...

journal_title：Neurochemical research

authors： Buntup D,Skare O,Solbu TT,Chaudhry FA,Storm-Mathisen J,Thangnipon W

更新日期：2008-02-01 00:00:00

abstract：:Effects of methylmercury (MetHg) on the specific [3H]flunitrazepam binding were studied in rat cortical and cerebellar P2-fractions in vitro. MetHg did not affect significantly the specific [3H]flunitrazepam binding in unwashed P2-fraction but increased it marginally (by 16%) at 100 microM in washed P2-fraction, in bo...

journal_title：Neurochemical research

authors： Komulainen H,Keränen A,Saano V

更新日期：1995-06-01 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...

journal_title：Neurochemical research

authors： Lanning CL,Wilmarth KR,Abou-Donia MB

更新日期：1994-09-01 00:00:00

abstract：:A Zn(2+)-glycerophosphocholine cholinephosphodiesterase was purified with a specific activity of 4.6 mumole/min.mg protein from bovine brain membranes by procedures involving PI-PLC solubilization, concanavalin A affinity chromatography, CM-sephadex chromatography and Sephadex G-150 chromatography. Based on molecular ...

journal_title：Neurochemical research

authors： Sok DE

更新日期：1996-10-01 00:00:00

abstract：:Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...

journal_title：Neurochemical research

authors： Liu P,Zhao P,Li B,Xu D,Wang K

更新日期：2020-12-01 00:00:00

abstract：:Direct evidence for the excitotoxicity of 3-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), the Lathyrus sativus neurotoxin has been studied by examining the binding of chemically synthesized [2,3 3H]ODAP ([3H]ODAP) to synaptic membranes. [3H]ODAP binding to membranes was mostly nonspecific, with only a very low s...

journal_title：Neurochemical research

authors： Jain RK,Junaid MA,Rao SL

更新日期：1998-09-01 00:00:00

abstract：:This study evaluates whether physiological variables differentially affect the local synthesis of protein constituents of synapses in subcellular fractions containing pinched-off dendrites (synaptodendrosomes). Synaptodendrosomes were pulse-labeled in a medium containing 35S-methionine with 3 or 25 mM KCl and in the p...

journal_title：Neurochemical research

authors： Leski ML,Steward O

更新日期：1996-06-01 00:00:00

abstract：:The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603 +/- 6 to 22 +/- 2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but d...

journal_title：Neurochemical research

authors： Hirsch JA,Gibson GE

更新日期：1984-08-01 00:00:00

abstract：:The present study examined the potential membrane retention of desipramine (DMI) following exposures of 293-hNET cells to DMI, and its effect on [3H]NE uptake. Incubation of cells with 500 nM DMI for 1 h or 1 day persistently inhibited the uptake of [3H]NE up to 7 days, despite daily repeated washing of cells with dru...

journal_title：Neurochemical research

authors： Zhu MY,Kyle PB,Hume AS,Ordway GA

更新日期：2004-02-01 00:00:00

abstract：:Zinc (Zn2+) was shown to invariably inhibit muscimol-stimulated 36Cl- uptake by synaptoneurosomes in the cerebral cortex, hippocampus and cerebellum. The Zn2+ sensitivity of the GABAA receptor-gated 36Cl- uptake in the cerebral cortex was comparable to that in the hippocampus, whereas the uptake in the cerebellum was ...

journal_title：Neurochemical research

authors： Ito Y,Segawa K,Kobayashi M,Fukuda H

更新日期：1996-08-01 00:00:00

abstract：:Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...

journal_title：Neurochemical research

authors： Maliszewski-Hall AM,Alexander M,Tkáč I,Öz G,Rao R

更新日期：2017-01-01 00:00:00

abstract：:Analysis in mouse brain slices of the uptake of acetyl-L-[N-methyl-14C]carnitine with time showed it to be concentrative, and kinetic analysis gave a Km of 1.92 mM and a Vmax of 1.96 mumol/min per ml, indicating the presence of a low-affinity carrier system. The uptake was energy-requiring and sodium-dependent, being ...

journal_title：Neurochemical research

authors： Burlina AP,Sershen H,Debler EA,Lajtha A

更新日期：1989-05-01 00:00:00

abstract：:The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was fou...

journal_title：Neurochemical research

authors： Strunsky EG,Borisover MD,Nikolsky EE,Vyskocil F

更新日期：2001-09-01 00:00:00

abstract：:Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) receptors. There are eight known mGlu receptor subtypes (mGlu1-8), which are widely expressed throughout the brain, and are divided into three group...

journal_title：Neurochemical research

authors： Mercier MS,Lodge D

更新日期：2014-10-01 00:00:00

abstract：:We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...

journal_title：Neurochemical research

authors： Herschman HR,Ferguson GD,Feldman JD,Farias-Eisner R,Vician L

更新日期：2000-05-01 00:00:00

abstract：:The mitochondrial enzyme, pyruvate carboxylase (PC; EC 6.4.1.1) is considered to play a significant role in the intermediary metabolism of neural tissue. PC-catalyzed carboxylation of pyruvate to oxaloacetate is a major anaplerotic reaction in brain. Anaplerosis is essential for homeostasis of the members of the trica...

journal_title：Neurochemical research

authors： Murin R,Cesar M,Kowtharapu BS,Verleysdonk S,Hamprecht B

更新日期：2009-03-01 00:00:00

abstract：:Hypoxia-induced oxidative stress is one of the major hallmark reasons underlying brain dysfunction. In the present manuscript, we have used CoCl2-induced hypoxic mice to investigate alterations in the activities of chief antioxidative stress enzymes- superoxide dismutase (SOD) and catalase (CAT) and expression of thei...

journal_title：Neurochemical research

authors： Rani A,Prasad S

更新日期：2014-09-01 00:00:00

abstract：:Danhong injection, a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is used extensively for the treatment of cerebrovascular diseases such as acutely cerebral infarction in clinic. In this study, we further investigated the mechanisms of Danhong inje...

journal_title：Neurochemical research

authors： Guo H,Li MJ,Liu QQ,Guo LL,Ma MM,Wang SX,Yu B,Hu LM

更新日期：2014-09-01 00:00:00

abstract：:This study was designed to investigate the protective effects of extracellular superoxide dismutase (SOD3) against hydrogen peroxide (H2O2) induced damage in human neuroblastoma SH-SY5Y cells and to elucidate the mechanisms responsible for this beneficial effect. SOD3-overexpressing SH-SY5Y cells were generated by ade...

journal_title：Neurochemical research

authors： Yang R,Wei L,Fu QQ,Wang H,You H,Yu HR

更新日期：2016-07-01 00:00:00

abstract：:The protein composition of myelin isolated from the CNS of four different fish species (trout, goldfish), eel, Tilapia) was analysed by SDS-polyacrylamide gel electrophoresis and compared with that of pig and rat brain. Thereby the following features were found typical to the myelin of fish: (1) a basic protein of par...

journal_title：Neurochemical research

authors： Jeserich G

更新日期：1983-08-01 00:00:00

abstract：:C-6 glial cells were studied in culture with respect to morphological and biochemical changes under several experimental conditions. Doubling time was 33 hr for cells plated at either 0.5 or 1.0×10(6) cells per flask. Markedly reduced cell growth and astrocyte-like appearance were observed following dibutyryl cyclic A...

journal_title：Neurochemical research

authors： Vernadakis A,Nidess R

更新日期：1976-08-01 00:00:00

abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...

journal_title：Neurochemical research

authors： Kim JS,Giacobini E

更新日期：1985-10-01 00:00:00

abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...

journal_title：Neurochemical research

authors： Hartley DM,Snodgrass SR

更新日期：1990-07-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expressi...

journal_title：Neurochemical research

authors： Corona JC,Duchen MR

更新日期：2015-02-01 00:00:00