Abstract：
:The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expression or activity of a number of genes in a variety of signalling networks. These include regulation of redox balance, fatty acid oxidation, immune responses and mitochondrial function. Recent studies suggest that the PPARγ agonists may serve as good candidates for the treatment of several neurodegenerative disorders including Parkinson's disease (PD), Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis, even though multiple etiological factors contribute to the development of these disorders. Recent reports have also signposted a role for PPARγ coactivator-1α (PGC-1α) in several neurodegenerative disorders including PD. In this review, we explore the current knowledge of mechanisms underlying the beneficial effects of PPARγ agonists and PGC-1α in models of PD.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Corona JC,Duchen MRdoi
10.1007/s11064-014-1377-0subject
Has Abstractpub_date
2015-02-01 00:00:00pages
308-16issue
2eissn
0364-3190issn
1573-6903journal_volume
40pub_type
杂志文章,评审abstract：:Sex differences exist in the functioning of the two brain corticosteroid receptor systems. Ovarian steroid replacement alters receptor mRNA expression, receptor binding capacities, and receptor affinity. The abundance of both mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) message can be reduced by es...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022023207326
更新日期：1997-11-01 00:00:00
abstract：:The activation of caspase-3 is considered to be a reliable marker for apoptotic cell death, and a 120-kDa fragment of αII-spectrin is generated by caspase-3 mediated cleavage of this structural protein. In the present study, we compared cleaved αII-spectrin (120-kDa) and cleaved caspase-3-immunoreactive cells and thei...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0633-9
更新日期：2012-03-01 00:00:00
abstract：:GABAA-receptors were localized in explant cultures of rat cerebellum and in dissociated primary cultures of rat cerebellar granule cells and rat cerebellar astrocytes using the monoclonal antibody bd-17 directed against the beta-subunit of the GABAA/benzodiazepine/chloride channel complex. At the light microscope leve...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966097
更新日期：1991-03-01 00:00:00
abstract：:Human neuroblastoma cholinergic LA-N-2 cells were used as an experimental model to test the possibility that the methylation of phosphoethanolamine (PEtn) to phosphocholine (PCho) and free choline (Cho) (Andriamampandry et al. 1989) could contribute to acetylcholine (AcCho) synthesis. LA-N-2 cells were incubated with ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966721
更新日期：1994-01-01 00:00:00
abstract：:Previous studies have shown that hypoxia induces nitric oxide synthase-mediated generation of nitric oxide free radicals leading to peroxynitrite production. The present study tests the hypothesis that hypoxia results in NO-mediated modification of Na+, K+-ATPase in the fetal brain. Studies were conducted in guinea pi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1012331108641
更新日期：2001-10-01 00:00:00
abstract：:Propofol and ketamine may provide certain degree of neuroprotection, but the underlying mechanism remains unclear to date. The cAMP response element-binding protein (CREB) was proposed that its phosphorylation at Ser133 (P-CREB) constituted a convergence point involved in neuroprotection. The purpose of this study was...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0582-3
更新日期：2012-01-01 00:00:00
abstract：:The hypothalamic paraventricular nucleus (PVN) is a key site for regulating neuroendocrine functions in the magnocellular part and autonomic activities in the parvocellular part. Its anatomical proximity to the third ventricle could be a good target for intrathecal injection of baclofen. We investigated the correlatio...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0621-0
更新日期：2012-02-01 00:00:00
abstract：:The efflux kinetics of 45Ca from rat brain cortex thin slices previously equilibrated with it, was studied in a superfusion system. Two first order kinetic components of efflux from the tissue were found: k2 = 0.0667 min-1, that was unchanged by lowering the temperature from 37 degrees C to 15 degrees, and k3 = 0.0167...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966071
更新日期：1982-11-01 00:00:00
abstract：:Incubation of membranes derived from sarcotubular system of rabbit skeletal muscle with increasing concentrations of Triton X-100 produced both stimulation of the AChE activity and solubilization of this enzyme. Mild proteolytic treatment of microsomal membranes produced a several fold activation of the still membrane...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969639
更新日期：1989-02-01 00:00:00
abstract：:Prion diseases are conformational diseases, many factors are involved in altering the conformation of prion, such as RNA, DNA, pH, and copper etc. However the neurotoxic mechanism of prion diseases is not clear yet. The aim of this study is to investigate the effect of the nucleoprotein complex of RNA and recombinant ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0506-2
更新日期：2011-10-01 00:00:00
abstract：:Metabolism of triacylglycerol (TAG) in developing brain has been examined. TAG is a relatively minor fraction of brain lipid in both suckling and adult rats and cannot be accounted for as entrapped blood. When glycerol tri[1-14C]oleate and [2-3H]glycerol trioleate were simultaneously injected intracerebrally into suck...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966679
更新日期：1981-11-01 00:00:00
abstract：:The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic ac...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967746
更新日期：1986-12-01 00:00:00
abstract：:Transferrin (Tf), the iron-transport protein of vertebrate serum, is mainly synthesized in hepatocytes but is also found in other cell-types including oligodendrocytes. Our laboratory has characterized in a human oligodendrial cell line the presence of a new Tf transcript containing an alternative exon 1b replacing th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021692220482
更新日期：2002-11-01 00:00:00
abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973648
更新日期：1990-07-01 00:00:00
abstract：:The steady-state mRNA levels of NGF, BDNF and NT-3, and the mRNA levels of their receptors p75NGFR, trk, trkB, and trkC were examined in various human peripheral neuropathies, to determine the correlation with myelinated fiber pathology and T cell and macrophage invasions in the diseased nerves. Steady state levels of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022434209787
更新日期：1998-06-01 00:00:00
abstract：:Level of adenosine, an endogenous astrocyte-based neuromodulator, is primarily regulated by adenosine P1 receptors. This study assessed expression of adenosine P1 receptors, ADORA1 (adenosine A1 receptor) and ADORA2A (adenosine A2a receptor) and their association with glioma development and epilepsy in glioma patients...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1893-1
更新日期：2016-07-01 00:00:00
abstract：:Myelinated axons were isolated by flotation from bovine pons, middle cerebellar peduncle, cervical spinal cord and three regions of the subcortical white matter. The myelinated axons were osmotically and mechanically shocked, followed by fractionation on a linear 15% sucrose to 45% sucrose density gradient. Axolemma-e...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01268880
更新日期：1988-05-01 00:00:00
abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965726
更新日期：1983-03-01 00:00:00
abstract：:N-terminal protein arginylation has been demonstrated in vitro and in situ and has been reported to increase following injury to sciatic nerves of rats. The present study attempts to demonstrate these reactions in vivo by applying [3H]Arg to the cut end of sciatic nerves in anesthetized rats and assaying for N-termina...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021998227237
更新日期：1997-12-01 00:00:00
abstract：:N-Methyl-D-aspartate (NMDA) and L-glutamate activate membrane receptors that produce substantial permeation of Na+, K+ and Ca2+ through the neuronal membrane. These ionic fluxes are intimately linked to processes that regulate neuronal survival, growth and differentiation. Intracellular free Ca2+ concentrations are th...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF00966862
更新日期：1992-01-01 00:00:00
abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965769
更新日期：1986-11-01 00:00:00
abstract：:Adaptive changes in serotonergic 5HT1 receptor signalling are believed to underlie the therapeutic effectiveness of antidepressant drugs. Since cells are continuously exposed to neurotransmitters/neuromodulators, spatially and temporally integrated, the responsiveness of a receptor system is dependent upon the physio-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9582-8
更新日期：2008-07-01 00:00:00
abstract：:Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03017-y
更新日期：2020-07-01 00:00:00
abstract：:Folic acid plays an important role in neuroplasticity and acts as a neuroprotective agent, as observed in experimental brain ischemia studies. The aim of this study was to investigate the effects of folic acid on locomotor activity, aversive memory and Na(+),K(+)-ATPase activity in the frontal cortex and striatum in a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0757-6
更新日期：2012-08-01 00:00:00
abstract：:The effect of postdecapitative ischemia (5 min at 37 degrees) and hypoxia (5% O2, 95% N2, 30 min) on the distribution of protein radioactivity in the cellular fractions of guinea pig cerebral cortex was studied. Ischemic conditions resulted in the increase of total radioactivity level and protein content in the mitoch...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963828
更新日期：1979-02-01 00:00:00
abstract：:This review presents data on metabotropic uridine nucleotide receptor subtypes (P2UR) activated by UTP, sometimes also by UDP and/or ATP. Some chemical details of receptor subtypes and ligand interactions are described. Ligand-activated P2UR subtypes may couple to different second messengers, yet little is known about...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022487128766
更新日期：1997-08-01 00:00:00
abstract：:We investigated the distribution of serotonin (5-HT) receptors of type 3 (5-HT3) in human brain areas, by means of the the specific binding of [3H]GR65630. The brains were obtained during autoptic sessions from 6 subjects. Human brain membranes and the binding of [3H]GR65630 were carried out according to standardized ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1010939530412
更新日期：2001-03-01 00:00:00
abstract：:MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is invol...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-018-2602-z
更新日期：2018-10-01 00:00:00
abstract：:Hippocampal cells dissociated from 5-day-old rat pups were grown in a suitable chemically defined basal medium, supplemented or not with 3,3',5-triiodo-L-thyronine (T3), [Arg8]-vasopressin (AVP), or both, at different concentrations. Four days after plating, neuron-like cells began to degenerate drastically in the bas...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965924
更新日期：1989-10-01 00:00:00
abstract：:Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2477-z
更新日期：2018-03-01 00:00:00
