Abstract：
:The aim of this study is to investigate differences in thyroid-stimulating hormone (TSH) level in patients with acute schizophrenia, unipolar depression, bipolar depression and bipolar mania. Serum level of TSH was measured in 1,685 Caucasian patients (1,064 women, 63.1%; mean age 46.4). Mean serum TSH concentration was: schizophrenia (n = 769) 1.71 μIU/mL, unipolar depression (n = 651) 1.63 μIU/mL, bipolar disorder (n = 264) 1.86 μIU/mL, bipolar depression (n = 203) 2.00 μIU/mL, bipolar mania (n = 61) 1.38 μIU/mL (H = 11.58, p = 0.009). Depending on the normal range used, the overall rate of being above or below the normal range was 7.9-22.3% for schizophrenia, 13.9-26.0% for unipolar depression, 10.8-27.6% for bipolar disorder, 12.2-28.5% for bipolar depression, and 11.4-24.5% for bipolar mania. We have also found differences in TSH levels between the age groups (≤20, >20 years and ≤40, >40 years and ≤60 years and >60 years). TSH level was negatively correlated with age (r = -0.23, p < 0.001). Weak correlations with age have been found in the schizophrenia (r = -0.21, p < 0.001), unipolar depression (r = -0.23, p < 0.001), bipolar depression (r = -0.25, p = 0.002) and bipolar disorder (r = -0.21, p = 0.005) groups. Our results confirm that there may be a higher prevalence of thyroid dysfunctions in patients with mood disorders (both unipolar and bipolar) and that these two diagnostic groups differ in terms of direction and frequency of thyroid dysfunctions.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Wysokiński A,Kłoszewska Idoi
10.1007/s11064-014-1305-3subject
Has Abstractpub_date
2014-07-01 00:00:00pages
1245-53issue
7eissn
0364-3190issn
1573-6903journal_volume
39pub_type
杂志文章abstract：:cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold or greater difference in normalized expression. RT-PCR analysis of a s...
journal_title：Neurochemical research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1984-07-01 00:00:00
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更新日期：1989-12-01 00:00:00
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更新日期：2000-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1999-09-01 00:00:00
abstract：:One pathway by which tryptophan is metabolized in the brain as well as in the periphery is through cleavage of the indole ring to formylkynurenine and then kynurenine. Indoleamine-2,3-dioxygenase, the enzyme that catalyzes this cleavage, and kynurenine are distributed all across the different anatomic regions of brain...
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更新日期：1980-03-01 00:00:00
