Abstract：
:Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39. Initially projected as a neuron-specific kinase, cdk5 is expressed ubiquitously and its kinase activity solely depends on the presence of its activators, which are also found in some non-neuronal tissues. As a multifunctional protein, cdk5 has been linked to axonogenesis, cell migration, exocytosis, neuronal differentiation and apoptosis. Cdk5 plays a critical role in functions other than normal physiology, especially in neurodegeneration. Its contribution to both normal physiological as well as pathological processes is mediated by its specific substrates. Cdk5-null mice are embryonically lethal, therefore making it difficult to study precisely what cdk5 does to the nervous system at early stages of development, be it neuron development or programmed cell death. Zebrafish model system bypasses the impediment, as it is amenable to reverse genetics studies. One of the functions that we have followed for the cdk5 ortholog in zebrafish in vivo is its effect on the Rohon-Beard (RB) neurons. RB neurons are the primary sensory spinal neurons that die during the first two days of zebrafish development eventually to be replaced by the dorsal root ganglia (DRG). Based on ours studies and others', here we discuss possible mechanisms that may be involved in cdk5's role in RB neuron development and survival.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Kanungo J,Zheng YL,Mishra B,Pant HCdoi
10.1007/s11064-008-9885-4subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1129-37issue
6eissn
0364-3190issn
1573-6903journal_volume
34pub_type
杂志文章,评审abstract：:Transferrin (Tf), the iron-transport protein of vertebrate serum, is mainly synthesized in hepatocytes but is also found in other cell-types including oligodendrocytes. Our laboratory has characterized in a human oligodendrial cell line the presence of a new Tf transcript containing an alternative exon 1b replacing th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021692220482
更新日期：2002-11-01 00:00:00
abstract：:It is reported that chitinase1 increases in Alzheimer's disease (AD). However, the alteration of chitinase1 in the progress of AD is still unclear. Thus, we designed the present study to detect chitinase1 level in different stages of APP/PS1 double transgenic mice. Experimental models were APP/PS1 double transgenic mi...
journal_title：Neurochemical research
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doi：10.1007/s11064-016-1874-4
更新日期：2016-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9149-0
更新日期：2006-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2307-8
更新日期：2017-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0004-y
更新日期：2009-12-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1993-12-01 00:00:00
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journal_title：Neurochemical research
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1976-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973648
更新日期：1990-07-01 00:00:00
abstract：:The endogenous sialidase (N-acetylneuraminidase) activity of membranes prepared from goldfish retina and optic tectum displays characteristics similar to those reported for neural plasma membrane sialidases of other organisms. Endogenous membrane sialidase activity was found to be optimal at ph 4.0, and maximal releas...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965657
更新日期：1983-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1990-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1753-4
更新日期：2016-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9151-6
更新日期：2007-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967978
更新日期：1986-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-0992-5
更新日期：2013-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1023/a:1020973023059
更新日期：1999-10-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1981-01-01 00:00:00
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更新日期：2015-07-01 00:00:00
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更新日期：2004-04-01 00:00:00
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更新日期：2004-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1990-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF03177490
更新日期：1998-12-01 00:00:00
abstract：:The protein composition of myelin isolated from the CNS of four different fish species (trout, goldfish), eel, Tilapia) was analysed by SDS-polyacrylamide gel electrophoresis and compared with that of pig and rat brain. Thereby the following features were found typical to the myelin of fish: (1) a basic protein of par...
journal_title：Neurochemical research
pub_type： 杂志文章
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
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更新日期：2003-06-01 00:00:00
abstract：:Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital. Isobolographic analysi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1812-x
更新日期：2016-05-01 00:00:00
abstract：:The present study has attempted to elucidate the alteration of serotonin turnover after 24 h REM sleep deprivation in different regions in brain of young rat. Sleep deprivation was induced by the inverted flower pot technique. Results of this study show increased serotonin turnover after 24 h REM sleep deprivation in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-9139-7
更新日期：2006-01-01 00:00:00
