Serotonin turnover in discrete regions of young rat brain after 24 h REM sleep deprivation.

abstract：:The long-acting opiate antagonist naltrexone hydrochloride was administered by intraperitoneal injection, in a dose response protocol, to adult rats. The drug was used to observe effects of opiate receptor blockade on cells of the pituitary gland and adjacent hypothalamus. At higher drug doses (5 mg/kg or 10 mg/kg), n...

journal_title：Neurochemical research

authors： Saland LC,Reyes E,Ortiz E

更新日期：1984-02-01 00:00:00

abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...

journal_title：Neurochemical research

authors： Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck EL

更新日期：2013-08-01 00:00:00

abstract：:Diminished thiamine (vitamin B1) dependent processes and oxidative stress accompany Alzheimer's disease (AD). Thiamine deficiency in animals leads to oxidative stress. These observations suggest that thiamin may act as an antioxidant. The current experiments first tested directly whether thiamin could act as an antiox...

journal_title：Neurochemical research

authors： Huang HM,Chen HL,Gibson GE

更新日期：2010-12-01 00:00:00

abstract：:Thiamine deficiency (TD) produces severe neurodegenerative lesions. Studies have suggested that primary neurodegenerative events are associated with both oxidative stress and inflammation. Very little is known about the downstream effects on intracellular signaling pathways involved in neuronal death. The primary aim ...

journal_title：Neurochemical research

authors： Medeiros RCN,Moraes JO,Rodrigues SDC,Pereira LM,Aguiar HQDS,de Cordova CAS,Yim Júnior A,de Cordova FM

更新日期：2020-04-01 00:00:00

abstract：:The effect of phenobarbital (100 mg/kg i.p.) and 6-aminonicotinamide (6AN) (35 mg/kg i.p.) on enzyme activities related to energy transduction was investigated on the homogenate "in toto", non-synaptic mitochondrial fraction and synaptosomal fraction isolated from different rat brain areas (cerebral cortex, hippocampu...

journal_title：Neurochemical research

authors： Marzatico F,Dagani F,Curti D,Benzi G

更新日期：1987-01-01 00:00:00

abstract：:The NG 108-15 (neuroblastoma X glioma hybrid) cell line was used as an in vitro neuronal model to evaluate potential antagonists of the Na+-selective carboxylic ionophore monensin. Changes in membrane electrical characteristics induced by monensin with and without the simultaneous administration of antagonists were me...

journal_title：Neurochemical research

authors： Doebler JA

更新日期：2000-07-01 00:00:00

abstract：:The effect of oxidative stress, induced by Fe(2+)-EDTA system, on Na+,K(+)-ATPase, Na+/CA2+ exchanger and membrane fluidity of synaptosomes was investigated. Synaptosomes isolated from gerbil whole forebrain were incubated in the presence of 200 microM FeSO4-EDTA per mg of protein at 37 degrees C for 30 min. The oxida...

journal_title：Neurochemical research

authors： Kaplán P,Matejovicová M,Mézesová V

更新日期：1997-12-01 00:00:00

abstract：:Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...

journal_title：Neurochemical research

authors： Ma J,Cui B,Ding X,Wei J,Cui L

更新日期：2015-08-01 00:00:00

abstract：:The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high levels of Glu at synapses during aging, we used transgenic (Tg) mice that over-express the enzyme ...

journal_title：Neurochemical research

authors： Choi IY,Lee P,Wang WT,Hui D,Wang X,Brooks WM,Michaelis EK

更新日期：2014-01-01 00:00:00

abstract：:Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...

journal_title：Neurochemical research

authors： Sitges M,Aldana BI,Reed RC

更新日期：2016-06-01 00:00:00

abstract：:The cellular effects of eleven compounds including chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives were studied in rat pheochromocytoma PC12 cells. Of the compounds tested, 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone (A2) significantly increased the levels of the phosph...

journal_title：Neurochemical research

authors： Nishina A,Kimura H,Tsukagoshi H,Kozawa K,Koketsu M,Ninomiya M,Sato D,Obara Y,Furukawa S

更新日期：2013-11-01 00:00:00

abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...

journal_title：Neurochemical research

authors： Jeong JI,Lee YW,Kim YK

更新日期：2003-08-01 00:00:00

abstract：:Glutamine synthetase (GS) is the major glutamine-forming enzyme of vertebrates and is accepted to be a marker of astroglial cells. Maturation of astroglial cells is characterized by an increase of GS activity, and the regulation of this enzyme is the topic of many publications. Because of the fundamental role of the G...

journal_title：Neurochemical research

authors： Haghighat N

更新日期：2005-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a promising biological marker and prognostic indicator in many neurological diseases. Although VEGF concentrations in plasma and cerebrospinal fluid (CSF) are increasingly reported, CSF-VEGF stability pre- and during-assay procedures is seldom evaluated. In the current stud...

journal_title：Neurochemical research

authors： Yang J,Dombrowski SM,Deshpande A,Krajcir N,El-Khoury S,Krishnan C,Luciano MG

更新日期：2011-11-01 00:00:00

abstract：:Postnatal developmental patterns of activity for acid and alkaline deoxyribonuclease (DNase) were determined in the cerebellum of the androgenized female rat. Littermates were injected s.c. with either 1.25 mg testosterone propionate (TP) or vehicle 48 hours after birth. The enzymes and DNA content were measured in th...

journal_title：Neurochemical research

authors： Litteria M

更新日期：1985-04-01 00:00:00

abstract：:Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles...

journal_title：Neurochemical research

authors： Shin EJ,Tran HQ,Nguyen PT,Jeong JH,Nah SY,Jang CG,Nabeshima T,Kim HC

更新日期：2018-01-01 00:00:00

abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...

journal_title：Neurochemical research

authors： Hartley DM,Snodgrass SR

更新日期：1990-07-01 00:00:00

abstract：:The number of c-Fos protein-like immunoreactive (c-Fos-IR) neurons in the spinal dorsal horn evoked by noxious stimulation was previously shown to be increased following peripheral nerve injury, and this increase was proposed to reflect the neuropathic pain state. The aim of this study was to investigate whether anoma...

journal_title：Neurochemical research

authors： Terayama R,Kishimoto N,Yamamoto Y,Maruhama K,Tsuchiya H,Mizutani M,Iida S,Sugimoto T

更新日期：2015-03-01 00:00:00

abstract：:Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...

journal_title：Neurochemical research

authors： Ripellino JA,Elam JS

更新日期：1980-04-01 00:00:00

abstract：:Tyrosinemia type II, also known as Richner-Hanhart syndrome, is an autosomal recessive inborn error of metabolism caused by a deficiency of hepatic cytosolic tyrosine aminotransferase, and is associated with neurologic and development difficulties in numerous patients. Considering that the mechanisms underlying the ne...

journal_title：Neurochemical research

authors： Macêdo LG,Carvalho-Silva M,Ferreira GK,Vieira JS,Olegário N,Gonçalves RC,Vuolo FS,Ferreira GC,Schuck PF,Dal-Pizzol F,Streck EL

更新日期：2013-12-01 00:00:00

abstract：:The effect of maternal hypoxia on the modification of the fetal brain cell membrane N-methyl-D-aspartate (NMDA) receptor and its modulatory sites was investigated. Experiments were conducted in pregnant guinea pigs of 60 days of gestation. Guinea pig fetuses were exposed to maternal hypoxia (FiO2 = 7%) for 60 minutes....

journal_title：Neurochemical research

authors： Mishra OP,Delivoria-Papadopoulos M

更新日期：1992-12-01 00:00:00

abstract：:The copper-transporting ATPases Atp7A and Atp7B play a major role in controlling intracellular copper levels. In addition, they are believed to deliver copper to the copper-requiring proteins destined for the secretory vesicles. One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepin...

journal_title：Neurochemical research

authors： Gerbasi V,Lutsenko S,Lewis EJ

更新日期：2003-06-01 00:00:00

abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...

journal_title：Neurochemical research

authors： Rath MF,Rohde K,Klein DC,Møller M

更新日期：2013-06-01 00:00:00

abstract：:Rat obturator nerve 16S acetylcholinesterase (16S AChE) was separated by sucrose gradient velocity sedimentation and compared to the 16S form of AChE similarly derived from endplate regions of anterior gracilis muscles. The 16S AChE from both tissues could only be extracted in high ionic strength buffer; as it aggrega...

journal_title：Neurochemical research

authors： Fernandez HL

更新日期：1981-09-01 00:00:00

abstract：:The Src family kinases are a family of intracellular, non-receptor tyrosine kinases that are involved in a variety of cellular functions including the regulation of inflammation and apoptosis after brain hypoxia. Caspase-1 (C1) activates IL-1β through the formation of complex structures, the inflammasomes, while caspa...

journal_title：Neurochemical research

authors： Angelis D,Fontánez Nieves TD,Delivoria-Papadopoulos M

更新日期：2015-11-01 00:00:00

abstract：:Transferrin (Tf), the iron-transport protein of vertebrate serum, is mainly synthesized in hepatocytes but is also found in other cell-types including oligodendrocytes. Our laboratory has characterized in a human oligodendrial cell line the presence of a new Tf transcript containing an alternative exon 1b replacing th...

journal_title：Neurochemical research

authors： Duchange N,Saleh MC,de Arriba Zerpa G,Pidoux J,Guillou F,Zakin MM,Baron B

更新日期：2002-11-01 00:00:00

abstract：:N-Acetylaspartic and N-acetylaspartylglutamic acid concentrations in human ventricular, subarachnoid and lumbar cerebrospinal fluid were measured by combined gas chromatography-mass spectrometry using selected ion monitoring with deuterated internal standards. N-Acetylaspartate concentrations were in the range 55, 9, ...

journal_title：Neurochemical research

authors： Faull KF,Rafie R,Pascoe N,Marsh L,Pfefferbaum A

更新日期：1999-10-01 00:00:00

abstract：:Growth-promoting macroglia (aldynoglia) with growth properties and immunological markers similar to Schwann cells, are found in loci of the mammalian CNS where axon regeneration occurs throughout life, like the olfactory sytem, hypothalamus-hypophysis and the pineal gland. Contrary to Schwann cells, aldynoglia mingle ...

journal_title：Neurochemical research

authors： Nieto-Sampedro M

更新日期：2003-11-01 00:00:00

abstract：:Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...

journal_title：Neurochemical research

authors： An L,Li G,Si J,Zhang C,Han X,Wang S,Jiang L,Xie K

更新日期：2016-05-01 00:00:00

abstract：:The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostria...

journal_title：Neurochemical research

authors： Reader TA,Ase AR,Huang N,Hébert C,van Gelder NM

更新日期：1998-01-01 00:00:00