Abstract:
:Lipid synthesis from acetoacetate and 3-hydroxybutyrate was studied in chick embryo from 15 to 21 days and in chick neonate from 1 to 21 days. Embryonic spinal cord showed higher ability than brain to incorporate acetoacetate into total lipids, although a sharp decrease was found at hatching. 3-Hydroxybutyrate incorporation into total lipids was also higher in spinal cord than in brain, especially during the embryonic period. Phospholipids were the main lipids formed in both tissues from both precursors. An appreciable percentage of radioactivity was also recovered as free cholesterol, especially during the embryonic phase. The developmental patterns of amino acid synthesis from acetoacetate and 3-hydroxybutyrate were similar in both tissues: a clear increase after hatching was followed by a decrease at day 4 of neonatal life. Acetoacetate was a better substrate for amino acid synthesis than 3-hydroxybutyrate during the embryonic development in both tissues. Oxidation of both precursors to CO2 strongly decreased between 15 and 21 days of embryonic development both in brain and spinal cord.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Linares A,Caamaño GJ,Diaz R,Gonzalez FJ,Garcia-Peregrin Edoi
10.1007/BF00966692subject
Has Abstractpub_date
1993-10-01 00:00:00pages
1107-12issue
10eissn
0364-3190issn
1573-6903journal_volume
18pub_type
杂志文章abstract::Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) receptors. There are eight known mGlu receptor subtypes (mGlu1-8), which are widely expressed throughout the brain, and are divided into three group...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-014-1415-y
更新日期:2014-10-01 00:00:00
abstract::It is well known that the principal biomolecules involved in Alzheimer's disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Aβ42). ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1400-5
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pub_type: 杂志文章
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journal_title:Neurochemical research
pub_type: 杂志文章,撤回出版物
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更新日期:2020-09-01 00:00:00
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更新日期:1990-06-01 00:00:00
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更新日期:2009-11-01 00:00:00
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更新日期:2003-01-01 00:00:00
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更新日期:2011-07-01 00:00:00
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更新日期:2013-03-01 00:00:00
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-04-01 00:00:00
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更新日期:1992-12-01 00:00:00
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更新日期:2000-12-01 00:00:00
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