Abstract：
:We examined the role of hippocampal metabotropic glutamate receptor 5 (mGlu5) in spatial learning and memory. Although it has been shown that mGlu5 signalling is required for certain forms of learning and memory, its role in spatial learning is unclear since studies using pharmacological or knockout mice models provide inconsistent findings. Additionally, the location in the brain where mGlu5 signalling may modulate such learning is yet to be precisely delineated. We stereotaxically injected rAAV-Cre into the dorsal hippocampus of mGlu5(loxP/loxP) mice to knockdown mGlu5 in that region. We show for the first time that knockdown of mGlu5 in the dorsal hippocampus is sufficient to impair spatial learning in Morris Water Maze. Locomotor activity and memory retrieval were unaffected by the mGlu5 knockdown. Taken together, these findings support a key role for dorsal hippocampal mGlu5 signalling in spatial learning.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Tan SZ,Ganella DE,Dick AL,Duncan JR,Ong-Palsson E,Bathgate RA,Kim JH,Lawrence AJdoi
10.1007/s11064-015-1595-0subject
Has Abstractpub_date
2015-06-01 00:00:00pages
1303-10issue
6eissn
0364-3190issn
1573-6903journal_volume
40pub_type
杂志文章abstract：:The purpose of this study was to investigate whether the kappa-opioid receptor (KOR) agonist, BRL52537, has a neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury in rats and further explore the underlying mechanisms. Adult male Sprague-Dawley rats were randomly assigned into sham (group A), I/R (...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1139-4
更新日期：2013-11-01 00:00:00
abstract：:In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different ages with several types of aging brain disorders. When compared with ac...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532336
更新日期：1996-08-01 00:00:00
abstract：:Over the past two decades the techniques associated with the manipulation of the mouse genome have provided a powerful approach toward the better understanding of gene function. Conventional transgenic and gene targeting approaches have been used extensively, and these techniques have been particularly rewarding for n...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1020772706279
更新日期：1999-09-01 00:00:00
abstract：:Exposure to Hg2+ below 10 micrometer destroys synaptosomal membrane-associated sialidase of bovine brain in situ. Inhibition by Cu2+ occurs only at relatively higher concentrations, and is demonstrable after the synaptosomal membrane preparation has been presaturated with Cu2+ . Pb2+ does not inhibit enzymatic activit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964363
更新日期：1978-02-01 00:00:00
abstract：:The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1262-x
更新日期：2014-04-01 00:00:00
abstract：:The effects of delta 9-tetrahydrocannabinol (delta 9-THC) administration on the central serotoninergic system were evaluated by biochemical assays of tissue levels of indoleamines; a measure of the serotonin (5-HT) innervation was obtained by using [3H]paroxetine as a marker of 5-HT uptake sites. Two different delta 9...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00978372
更新日期：1993-11-01 00:00:00
abstract：:Epileptogenesis, induced by status epilepticus (SE), is a chronic process, and intervention in this progress may prevent chronic epilepsy. It has been proposed that DNA methylation might be related with epileptogenesis. RASgrf1 has a differentially methylated region at the promoter which can silence gene expression. W...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2621-9
更新日期：2018-10-01 00:00:00
abstract：:We have previously showed that peptide neurotensin inhibits neuronal Na(+), K(+)-ATPase activity, an effect which involves high affinity neurotensin receptor. Nitric oxide (NO) acts as a neurotransmitter or as a neuromodulator when it is synthesized by neuronal nitric oxide synthase. Neurotensin effect on Na(+), K(+)-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0552-9
更新日期：2011-12-01 00:00:00
abstract：:The release of endogenous amino acids from depolarized rat hippocampal mossy fiber synaptosomes was investigated to assess the possible role(s) of glutamate and aspartate in mediating the excitatory mossy fiber synaptic input. The relative proportions of prodynorphin-derived peptides concomitantly released with amino ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969176
更新日期：1990-01-01 00:00:00
abstract：:Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we cha...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9434-6
更新日期：2008-01-01 00:00:00
abstract：:The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are al...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF02529142
更新日期：1996-02-01 00:00:00
abstract：:Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain, many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, man...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0280-6
更新日期：2011-01-01 00:00:00
abstract：:Proteolipid protein (PLP) is the major intrinsic membrane protein of CNS myelin and is expressed in oligodendrocytes as part of a coordinate program of myelin-specific gene activation. In order to identify the DNA sequences and proteins involved in the regulation of PLP transcription, we have analyzed the 5' flanking ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968716
更新日期：1994-08-01 00:00:00
abstract：:Diisopropyl phosphorofluoridate (DFP) produces organophosphorus ester-induced delayed neurotoxicity (OPIDN) in sensitive species. We have investigated the in vivo and in vitro effects of DFP on hen brain tubulin polymerization. Hens were treated with a single dose of DFP (1.7 mg/kg, sc.), and were sacrificed after 18-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967321
更新日期：1994-04-01 00:00:00
abstract：:The uptake of radioactive ethanolamine has been studied in exclusively neuronal and glial cell cultures from dissociated cerebral hemispheres of chick embryos. Both cell types show saturable kinetics; neurons have an apparent Km of 6.7 microM, Vmax 41.4 pmol mg prot.-1 min-1 and glial cells a Km of 119.6 microM, Vmax ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965162
更新日期：1986-01-01 00:00:00
abstract：:Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to identify genes whose expression is modulated due to the over-expression of human mutant presenilin-2 (N141I) (hPS2m) in transgenic mice, which has previously been p...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-6787-6
更新日期：2005-08-01 00:00:00
abstract：:Astrocyte-neuron communication has recently been proposed as a potential mechanism participating to synaptic transmission. With the development of this concept and accumulating evidences in favor of a modulation of synaptic transmission by astrocytes, has emerged the term gliotransmission. It refers to the capacity of...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0807-0
更新日期：2012-11-01 00:00:00
abstract：:During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-015-1545-x
更新日期：2015-12-01 00:00:00
abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02734-3
更新日期：2019-04-01 00:00:00
abstract：:The kinetics of the uptake of p-tyramine, m-tyramine, and dopamine were investigated in slices of the hypothalamus and striatum of the rat in the presence of nialamide. When uptake was analyzed by a least-squares fit to a Lineweaver-Burk plot, each amine appeared to be concentrated by both a "low"-affinity and a "high...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964440
更新日期：1979-10-01 00:00:00
abstract：:In membranes of rat striatum, phorbol 12-myristate 13-acetate (PMA), a potent activator of Ca2+/phospholipid-dependent protein kinase, enhanced adenylate cyclase activity by counteracting the inhibition elicited by GTP. Exposure to pertussis toxin caused a similar alteration of the GTP-regulation of the enzyme activit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01101712
更新日期：1990-11-01 00:00:00
abstract：:The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in developing cerebellum in addition to their tyrosine kinase receptors. TrkB and TrkC. In contrast to BDNF.NT-3 has only a negligible or a transient survival activity on cultured cerebellar granule neurons. The gra...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532309
更新日期：1996-07-01 00:00:00
abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1880-6
更新日期：2016-07-01 00:00:00
abstract：:Staurosporine was found to bring about complete growth inhibition of human glioma cell lines. U87 MG cells were arrested in S phase while U373 MG cells in G2/M phase on staurosporine treatment. Consistent with this observation, no change in G1 phase regulators viz., Cyclin D1, D3 and CDK4 was seen on staurosporine tre...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9068-0
更新日期：2006-05-01 00:00:00
abstract：:We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA)...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9197-5
更新日期：2006-12-01 00:00:00
abstract：:(E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine (HOEC), a naturally caffeic ester isolated from Incarvillea mairei, has been reported to possess anti-inflammatory activity by targeting 5-lipoxygenase. However, its other potential activities have yet to be explored. In this study, we measured antioxidant activity of ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1498-5
更新日期：2015-03-01 00:00:00
abstract：:Thiamine deficiency (TD) produces severe neurodegenerative lesions. Studies have suggested that primary neurodegenerative events are associated with both oxidative stress and inflammation. Very little is known about the downstream effects on intracellular signaling pathways involved in neuronal death. The primary aim ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-02975-7
更新日期：2020-04-01 00:00:00
abstract：:Social isolation is one of the most potent stressors in the prepubertal period and may influence disease susceptibility or resilience in adulthood. The glucocorticoid response and, consequently, the adaptive response to stress involve important changes in mitochondrial functions and apoptotic signaling. Previous studi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0915-x
更新日期：2013-02-01 00:00:00
abstract：:The subcellular distribution of Ca2+/calmodulin-stimulated adenylate cyclase activity was studied in comparison with that of guanine nucleotide-stimulated cyclase activity. The distributions of these activities were similar among the crude fractions but differed among the purified subsynaptosomal fractions. The specif...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965018
更新日期：1986-03-01 00:00:00
abstract：:Alzheimer's disease is a neurodegenerative disease characterized by the production of β-amyloid proteins and hyperphosphorylation of tau protein. Inflammation and apoptotic severity were highly correlated with earlier age at onset of Alzheimer's disease and were also associated with cognitive decline. This study aims ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0866-2
更新日期：2012-12-01 00:00:00
