Abstract:
:The uptake of radioactive ethanolamine has been studied in exclusively neuronal and glial cell cultures from dissociated cerebral hemispheres of chick embryos. Both cell types show saturable kinetics; neurons have an apparent Km of 6.7 microM, Vmax 41.4 pmol mg prot.-1 min-1 and glial cells a Km of 119.6 microM, Vmax 3,917 pmol mg prot-1 min-1. The lower affinity of the transport and the 100 fold increase in Vmax observed in glial cells correlated with a more important accumulation of free ethanolamine found in glial cells and with a higher degree of phosphorylation of ethanolamine. The uptake appeared to be temperature and Na+ ions dependent but was not affected by CN- or ouabain. Monomethyl-, dimethylethanolamine and choline were effective in inhibiting the uptake. Little or no effect was observed with serine, methionine, carnitine, alanine or glutamate.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Massarelli AC,Dainous F,Hoffmann D,Mykita S,Freysz L,Dreyfus H,Massarelli Rdoi
10.1007/BF00965162subject
Has Abstractpub_date
1986-01-01 00:00:00pages
29-36issue
1eissn
0364-3190issn
1573-6903journal_volume
11pub_type
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