Retention of a dialkylphosphatidylcholine in myelin and other membranes.

abstract：:T-588(R(-)-1-(benzo(b)thiophen-5yl)-2-[2(N,N-diethylamino)ethoxy]ethanol hydrochloride) is a novel compound which has been shown to exhibit a wide range of neurotrophic effects both in vivo and in vitro. This compound can slow the motor deterioration of wobbler mouse motor neuron disease. However, it is not known whet...

journal_title：Neurochemical research

authors： Iwasaki Y,Ikeda K,Ichikawa Y,Igarashi O,Kinoshita M,Marubuchi S,Ono S

更新日期：2002-03-01 00:00:00

abstract：:Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...

journal_title：Neurochemical research

authors： Perry G,Nunomura A,Raina AK,Aliev G,Siedlak SL,Harris PL,Casadesus G,Petersen RB,Bligh-Glover W,Balraj E,Petot GJ,Smith MA

更新日期：2003-10-01 00:00:00

abstract：:The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease the Km for acetylthiocholine, without changes in Vmas. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity...

journal_title：Neurochemical research

authors： Pastuszko A

更新日期：1980-07-01 00:00:00

abstract：:There is increasing evidence that proteins normally involved in the cell cycle play a role in the regulation of neuronal apoptotic death following various insults. However, it is not clear if the same mechanisms regulate cell death of oligodendrocytes as well. In this study, we investigated the mechanism of ceramide-i...

journal_title：Neurochemical research

authors： Strazza M,Luddi A,Brogi A,Carbone M,Riccio M,Santi S,Melli M,Costantino-Ceccarini E

更新日期：2004-05-01 00:00:00

abstract：:Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activ...

journal_title：Neurochemical research

authors： Chechik T,Poduslo SE

更新日期：1987-01-01 00:00:00

abstract：:In the present work we investigated the in vitro effect of the branched-chain amino acids (BCAA) accumulating in maple syrup urine disease (MSUD) on some parameters of energy metabolism in cerebral cortex of rats. 14CO2 production from [1-14C]acetate, [1-5-14C]citrate and [U-14C]glucose, as well as glucose uptake by t...

journal_title：Neurochemical research

authors： Ribeiro CA,Sgaravatti AM,Rosa RB,Schuck PF,Grando V,Schmidt AL,Ferreira GC,Perry ML,Dutra-Filho CS,Wajner M

更新日期：2008-01-01 00:00:00

abstract：:Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...

journal_title：Neurochemical research

authors： Florian CL,Williams SR,Bhakoo KK,Noble MD

更新日期：1996-09-01 00:00:00

abstract：:Folic acid plays an important role in neuroplasticity and acts as a neuroprotective agent, as observed in experimental brain ischemia studies. The aim of this study was to investigate the effects of folic acid on locomotor activity, aversive memory and Na(+),K(+)-ATPase activity in the frontal cortex and striatum in a...

journal_title：Neurochemical research

authors： Carletti JV,Deniz BF,Miguel PM,Rojas JJ,Kolling J,Scherer EB,de Souza Wyse AT,Netto CA,Pereira LO

更新日期：2012-08-01 00:00:00

abstract：:C-6 glial cells were studied in culture with respect to morphological and biochemical changes under several experimental conditions. Doubling time was 33 hr for cells plated at either 0.5 or 1.0×10(6) cells per flask. Markedly reduced cell growth and astrocyte-like appearance were observed following dibutyryl cyclic A...

journal_title：Neurochemical research

authors： Vernadakis A,Nidess R

更新日期：1976-08-01 00:00:00

abstract：:Turnover rate of individual molecular species of sphingomyelin of adult rat brain myelin and microsomal membranes was determined after an intracerebral injection of 100 microCi of [C3H3]choline. Myelin and microsomal membrane sphingomyelins were isolated from the rest of the lipids. The individual molecular species of...

journal_title：Neurochemical research

authors： LeBaron FN,Sanyal S,Jungalwala FB

更新日期：1981-10-01 00:00:00

abstract：:To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...

journal_title：Neurochemical research

authors： Tanaka K,Asanuma M,Ogawa N

更新日期：2004-08-01 00:00:00

abstract：:The protein composition of myelin isolated from the CNS of four different fish species (trout, goldfish), eel, Tilapia) was analysed by SDS-polyacrylamide gel electrophoresis and compared with that of pig and rat brain. Thereby the following features were found typical to the myelin of fish: (1) a basic protein of par...

journal_title：Neurochemical research

authors： Jeserich G

更新日期：1983-08-01 00:00:00

abstract：:We have previously shown that angiotensin II (Ang II) stimulates astrocyte growth through activation of ERK1/2 mitogen activated protein (MAP) kinases. In the current study, we determined whether Ang II stimulates the expression of c-fos, c-jun and c-myc in brainstem astrocyte cultures. Reverse transcriptase-PCR analy...

journal_title：Neurochemical research

authors： Delaney J,Chiarello R,Villar D,Kandalam U,Castejon AM,Clark MA

更新日期：2008-03-01 00:00:00

abstract：:Impaired glucose transport across brain tissue barriers causes infantile seizures, developmental delay and acquired microcephaly. Since the first report in 1991 (De Vivo et al, NEJM, 1991) 17 patients have been identified with the glucose transporter protein syndrome (GTPS). The diagnostic feature of the syndrome is a...

journal_title：Neurochemical research

authors： Klepper J,Wang D,Fischbarg J,Vera JC,Jarjour IT,O'Driscoll KR,De Vivo DC

更新日期：1999-04-01 00:00:00

abstract：:28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffeoyl triterpene with little information associated with its pharmacological target(s). To date no data is av...

journal_title：Neurochemical research

authors： Liu X,Ruan Z,Shao XC,Feng HX,Wu L,Wang W,Wang HM,Mu HY,Zhang RJ,Zhao WM,Zhang HY,Zhang NX

更新日期：2021-01-03 00:00:00

abstract：:We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...

journal_title：Neurochemical research

authors： Morell P,Jurevics H

更新日期：1996-04-01 00:00:00

abstract：:Effects of single and repeated doses of acrylamide on fast and slow axonal transport of radio labeled proteins following the injection of L-[4,5-3H] leucine have been studied in the optic system of male Sprague-Dawley rats. A single dose of acrylamide (100 mg/kg) had no effect, but higher concentrations (200-300 mg/kg...

journal_title：Neurochemical research

authors： Sabri MI,Spencer PS

更新日期：1990-06-01 00:00:00

abstract：:Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation and chemotherapy, this cancer recurs within short time and median survival after diagnosis is less than a year. Glioblastoma stem cells (GSCs) left in the brain after surgery is thought to explain the inevitable recurre...

journal_title：Neurochemical research

authors： Skjellegrind HK,Fayzullin A,Johnsen EO,Eide L,Langmoen IA,Moe MC,Vik-Mo EO

更新日期：2016-07-01 00:00:00

abstract：:The activity of gamma-glutamyltransferase localized in isolated brain synaptic membranes- and microvessels-enriched fractions was assayed after treatment of rats with either phenobarbital or ethanol. Phenobarbital increased the activity of gamma-glutamyltransferase in microvessels, without alteration of synaptic membr...

journal_title：Neurochemical research

authors： Ghersi-Egea JF,Minn A,Siest G

更新日期：1987-04-01 00:00:00

abstract：:The levels of selected neuroregulatory proteins that inhibit or promote apoptotic cell death were measured in the striatum of piglets subjected to precisely controlled 1 h hypoxic insult followed by 0, 2 and 4 h recovery and compared to sham operated animals. The anti-apoptotic proteins: there were increases in Surviv...

journal_title：Neurochemical research

authors： Mammen A,Kubin J,Greeley WJ,Schears GJ,Pastuszko P,F Wilson D,Pastuszko A

更新日期：2011-05-01 00:00:00

abstract：:The effect of oxidative stress, induced by Fe(2+)-EDTA system, on Na+,K(+)-ATPase, Na+/CA2+ exchanger and membrane fluidity of synaptosomes was investigated. Synaptosomes isolated from gerbil whole forebrain were incubated in the presence of 200 microM FeSO4-EDTA per mg of protein at 37 degrees C for 30 min. The oxida...

journal_title：Neurochemical research

authors： Kaplán P,Matejovicová M,Mézesová V

更新日期：1997-12-01 00:00:00

abstract：:Alterations in lysosomal proteases have been implicated in many neurodegenerative diseases. The current study demonstrates a concentration-dependent decrease in PC12 cell viability and transient changes in cystatin C (CYSC), cathepsin B (CATB), cathepsin D (CATD) and caspase-3 following exposure to H2O2. Furthermore, ...

journal_title：Neurochemical research

authors： Lee DC,Mason CW,Goodman CB,Holder MS,Kirksey OW,Womble TA,Severs WB,Palm DE

更新日期：2007-09-01 00:00:00

abstract：:Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...

journal_title：Neurochemical research

authors： Quay WB

更新日期：1989-10-01 00:00:00

abstract：:It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...

journal_title：Neurochemical research

authors： Vacotto M,Rapacioli M,Flores V,de Plazas SF

更新日期：2010-10-01 00:00:00

abstract：:The characteristics and properties of the increase in cytosolic [Ca2+] that occurs in bovine adrenal medullary chromaffin cells on exposure to angiotensin 11 have been investigated. In fura-2 loaded cells exposure to a maximally effective concentration of angiotensin II (100 nM) caused a rapid, but transient increase ...

journal_title：Neurochemical research

authors： Powis DA,Zerbes M,Herd LM,Dunkley PR

更新日期：2003-09-01 00:00:00

abstract：:Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about...

journal_title：Neurochemical research

authors： Kennedy SH,Davis BA,Brown GM,Ford CG,d'Souza J

更新日期：1993-12-01 00:00:00

abstract：:The chemical warfare nerve agent (CWNA) soman irreversibly inhibits acetylcholinesterase (AChE) causing seizure, neuropathology and neurobehavioral deficits. Pyridostigmine bromide (PB), the currently approved pretreatment for soman, is a reversible AChE inhibitor that does not cross the blood-brain barrier (BBB) to p...

journal_title：Neurochemical research

authors： Wang Y,Wei Y,Oguntayo S,Jensen N,Doctor BP,Nambiar MP

更新日期：2011-12-01 00:00:00

abstract：:It is reported that chitinase1 increases in Alzheimer's disease (AD). However, the alteration of chitinase1 in the progress of AD is still unclear. Thus, we designed the present study to detect chitinase1 level in different stages of APP/PS1 double transgenic mice. Experimental models were APP/PS1 double transgenic mi...

journal_title：Neurochemical research

authors： Xiao Q,Shi R,Yang W,Zou Y,Du Y,Zhang M,Yu W,Lü Y

更新日期：2016-07-01 00:00:00

abstract：:The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968. The characteristic feature of aging com...

journal_title：Neurochemical research

authors： Takeda T

更新日期：2009-04-01 00:00:00

abstract：:1-Methyl-4-phenylpyridinium (MPP(+)) or 6-hydroxydopamine (6-OHDA) caused a nuclear damage, the mitochondrial membrane permeability changes, leading to the cytochrome c release and caspase-3 activation, the formation of reactive oxygen species and the depletion of GSH in PC12 cells. Nicardipine (a calcium channel bloc...

journal_title：Neurochemical research

authors： Lee DH,Han YS,Han ES,Bang H,Lee CS

更新日期：2006-07-01 00:00:00