Abstract:
:Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to adult, while the related compound N-acetylaspartylglutamate was highest in adult optic nerve. Creatine and choline-containing compounds were present in all regions throughout development, with higher levels of creatine found in grey matter compared to other regions. Choline-containing compounds were present at the highest concentrations in the eye at all ages examined, and tended to decrease in concentration to minimum values in adulthood in all regions. The presence of hypotaurine in corpus callosum and optic nerve was consistent with the metabolic profiles of O-2A progenitor cells and oligodendrocytes, which are cells composing these tissues. The neurotransmitters glutamate and GABA reached their highest concentrations in the olfactory bulb (higher than in adult cortex).
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Florian CL,Williams SR,Bhakoo KK,Noble MDdoi
10.1007/BF02532417subject
Has Abstractpub_date
1996-09-01 00:00:00pages
1065-74issue
9eissn
0364-3190issn
1573-6903journal_volume
21pub_type
杂志文章abstract::We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1010999622760
更新日期:2001-06-01 00:00:00
abstract::Ferulago angulata (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, hemorrhoids, snake bite, ulcers and as sedative. In the present study, the effects of inhaled F. angulata essential oil (1 and 3%, daily, for 21 days) o...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1662-6
更新日期:2015-09-01 00:00:00
abstract::A Zn(2+)-glycerophosphocholine cholinephosphodiesterase was purified with a specific activity of 4.6 mumole/min.mg protein from bovine brain membranes by procedures involving PI-PLC solubilization, concanavalin A affinity chromatography, CM-sephadex chromatography and Sephadex G-150 chromatography. Based on molecular ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02532395
更新日期:1996-10-01 00:00:00
abstract::A study was undertaken in rats to evaluate the effects of short-term oral ethanol administration on the levels of fatty acid ethyl esters (FAEE) in brain and peripheral organs in the presence and absence of pretreatment with L-carnitine. Administration of ethanol to rats for seven days resulted in fatty acid ethyl est...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020984114824
更新日期:1999-01-01 00:00:00
abstract::One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9288-y
更新日期:2007-07-01 00:00:00
abstract::It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966062
更新日期:1982-11-01 00:00:00
abstract::Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2284-y
更新日期:2018-01-01 00:00:00
abstract::We examined the effects of small unilamellar vesicles composed of dipalmitoylphosphatidylcholine on rat cerebral cortical [3H]acetylcholine release. Synaptosomes from this region were loaded with the labeled transmitter, and then incubated with the lipid (0-6 mg/ml) for specified intervals before adding various secret...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00970530
更新日期:1987-08-01 00:00:00
abstract::Bilateral injection of 6-hydroxydopamine into the medial forebrain bundle (MFB) significantly decreased monoamine concentrations in the hypothalamus. The noradrenaline and serotonin content of the paraventricular nucleus (PVN) was also significantly reduced. These drastic decreases in neurotransmitter concentration di...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01474679
更新日期:1993-02-01 00:00:00
abstract::Malformations of cortical development (MCD) are critical brain development disorders associated with varied abnormalities in both anatomic structures and neural functioning. It is also a very common etiology to the epilepsy, in which the alteration on excitability of cortical neurons is hypothesized as one of importan...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1936-7
更新日期:2016-09-01 00:00:00
abstract::The present work describes the kinetics of enkephalin hydrolysis by plasma enzymes and the fragmentation pattern of both the parent peptide and of the first hydrolysis by-products. The degradation kinetics were followed by positive identification of the hydrolysis fragments by chromatographic methods, by amino acid an...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964980
更新日期:1985-10-01 00:00:00
abstract::Mutations in presenilin 1 (PS-1) are associated with most early-onset familiar Alzheimer's disease (AD). Previous studies have demonstrated that PS-1 mutations enhance the production of beta-amyloid (Aβ). In this study, we further examined the in vivo effects of PS-1 mutation on tau and synapse protein markers. The da...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0575-2
更新日期:2012-01-01 00:00:00
abstract::Effects of methylmercury (MetHg) on the specific [3H]flunitrazepam binding were studied in rat cortical and cerebellar P2-fractions in vitro. MetHg did not affect significantly the specific [3H]flunitrazepam binding in unwashed P2-fraction but increased it marginally (by 16%) at 100 microM in washed P2-fraction, in bo...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01705532
更新日期:1995-06-01 00:00:00
abstract::Neuroglycan C (NGC) is a transmembrane-type chondroitin sulfate proteoglycan that promotes neurite outgrowth. To identify the ligand of NGC, we applied a detergent-solubilized membrane fraction of fetal rat brains to an NGC-immobilized affinity column. Several proteins were eluted from the column including an 18 kDa-b...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0164-9
更新日期:2010-08-01 00:00:00
abstract::A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966022
更新日期:1977-02-01 00:00:00
abstract::Astrocytes occupy a strategic position in the brain where they can act as an interface between neurones and blood vessels, and neurones and the cerebro-spinal fluid. This location is ideal for functioning as interoceptors, as they may sense changes in brain microenvironment and contribute to the adaptive homeostatic r...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1562-9
更新日期:2015-12-01 00:00:00
abstract::Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1840-1
更新日期:2016-06-01 00:00:00
abstract::Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964224
更新日期:1980-04-01 00:00:00
abstract::Bilateral lesion of the nucleus basalis with ibotenic acid infusions in young and aged rats results in the degeneration of cholinergic neurons which innervate the cortex. As expected, high-affinity uptake of choline was decreased in the frontal cortex subsequent to the lesion. Twenty one days after surgery there was a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00974576
更新日期:1992-04-01 00:00:00
abstract::Transgenic therapy for central neuralgia faces the problems of low expression and weak targeting and affects superficial but not deep neurons. In this study, we generated a lentivirus vector with human preproenkephalin gene (hPPE) expression driven by the transcriptional amplification strategy system (TAS) and establi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03068-1
更新日期:2020-09-01 00:00:00
abstract::Human amniotic membrane mesenchymal stem cells (hAMSCs) are considered ideal candidate stem cells for cell-based therapy. In this study, we assessed whether hAMSCs transplantation promotes neurological functional recovery in rats after traumatic spinal cord injury (SCI). In addition, the potential mechanisms underlyin...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1987-9
更新日期:2016-10-01 00:00:00
abstract::Subacute exposure to manganese (Mn) produced Parkinson's disease-like syndrome called Manganism. Chronic onset and progression are characteristics of Manganism, therefore, this study aimed to examine Mn toxicity following chronic exposures. Male Sprague-Dawley rats were injected Mn2+ 1 and 5 mg/kg, every 10 days for 1...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03059-2
更新日期:2020-08-01 00:00:00
abstract::"Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model of temporal lobe epilepsy. At the present work we investigated the contribution of NMDA receptors in the Pentylenetetrazol-induced "kindling" model in the mouse brain, by using quantitative autoradiography and the radioa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021143813935
更新日期:1999-12-01 00:00:00
abstract::Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specif...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966702
更新日期:1991-11-01 00:00:00
abstract:UNLABELLED:Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0788-z
更新日期:2012-08-01 00:00:00
abstract::Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in E1 mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug admi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969763
更新日期:1989-01-01 00:00:00
abstract::Evidence that brain glutamatergic activity is pathologically elevated in bipolar disorder suggests that mood stabilizers are therapeutic in the disease in part by downregulating glutamatergic activity. Such activity can involve the second messenger, arachidonic acid (AA, 20:4n - 6). We tested this hypothesis with rega...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9700-2
更新日期:2008-11-01 00:00:00
abstract::It is an honour to have this opportunity write an article in recognition of the immense contributions of Bruce Ransom to the field of glial research. For me (BAM) personally there are many highlights both as a colleague and a friend that come to mind when I reflect on the many years that I have known Bruce. My own ent...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2315-8
更新日期:2017-09-01 00:00:00
abstract::The activity of guanine deaminase (GAH, E.C.3.5.4.3) was lower in rat cerebellum soluble and microsomal fractions than in rat brain subfractions. Adenosine deaminase (ADA, E.C.3.5.4.4) activity was released in higher proportion than guanine deaminase, purine nucleoside phosphorylase (PNP, E.C.2.1.2.4), 5'-nucleotidase...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965016
更新日期:1986-03-01 00:00:00
abstract::Activation of cholinergic muscarinic receptors results in an increased turnover of membrane inositol phospholipids. In rat cerebral cortex slices, carbachol- and acetylcholine-induced inositol phosphates ([3H]InsPs) accumulation is maximal in 7 day-old rats and lowest in adults, while the density of muscarinic binding...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969181
更新日期:1990-01-01 00:00:00