Abstract：
:Natural products including those derived from plants, have over the years greatly contributed to the development of therapeutic drugs. Polygodial and drimanial are sesquiterpenes isolated from the bark of the plant Drymis Winteri (Winteraceae) that exhibit antinociceptive properties. Since peripheral glutamate presents nociceptive actions, in this study it was investigated the effects of hydroalcooholic extracts from Drymis winteri (polygodial and drimanial) on the glutamatergic system in rat brain. Polygodial and drimanial inhibited glutamate uptake by astrocytes, as well as by cortical, hippocampal and striatal slices, and increased synaptosomal glutamate release. These concurrent effects would predispose to an increase in the extracellular glutamate concentrations, leading to possible neurotoxic effects (excitotoxicity) of these natural compounds, which would suggest the need for some caution in their therapeutic application.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Martini LH,Cereser L,Junior IZ,Jardim FM,Vendite DA,Frizzo ME,Yunes RA,Calixto JB,Wofchuk S,Souza DOdoi
10.1007/s11064-005-9033-3subject
Has Abstractpub_date
2006-03-01 00:00:00pages
431-8issue
3eissn
0364-3190issn
1573-6903journal_volume
31pub_type
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