Dynamic Changes in miR-126 Expression in the Hippocampus and Penumbra Following Experimental Transient Global and Focal Cerebral Ischemia-Reperfusion.

abstract：:The effects of vinpocetine on internal Na+ (Na(i)), cAMP accumulation, internal Ca2+ (Ca(i)) and excitatory amino acid neurotransmitters release, under resting and under depolarized conditions, was investigated in rat striatum synaptosomes. Veratridine (20 microM) or high K+ (30 mM) were used as depolarizing agents. R...

journal_title：Neurochemical research

authors： Sitges M,Nekrassov V

更新日期：1999-12-01 00:00:00

abstract：:Rat posterior eyecups containing the retina were prepared, loaded with [(3)H]glycine and superfused in order to determine its release originated from glycinergic amacrine cells and/or glial cells. Deprivation of oxygen and glucose from the Krebs-bicarbonate buffer used for superfusion evoked a marked increase of [(3)H...

journal_title：Neurochemical research

authors： Hanuska A,Szénási G,Albert M,Koles L,Varga A,Szabo A,Matyus P,Harsing LG Jr

更新日期：2016-02-01 00:00:00

abstract：:The finding that ketamine, an anaesthetic, can elicit a rapid antidepressant effect at low doses that lasts for weeks in patients with depression is arguably a major achievement in psychiatry in the last decades. However, the mechanisms of action are unclear. The glutamatergic hypothesis of ketamine action posits that...

journal_title：Neurochemical research

authors： Stenovec M,Božić M,Pirnat S,Zorec R

更新日期：2020-01-01 00:00:00

abstract：:The Src family kinases are a family of intracellular, non-receptor tyrosine kinases that are involved in a variety of cellular functions including the regulation of inflammation and apoptosis after brain hypoxia. Caspase-1 (C1) activates IL-1β through the formation of complex structures, the inflammasomes, while caspa...

journal_title：Neurochemical research

authors： Angelis D,Fontánez Nieves TD,Delivoria-Papadopoulos M

更新日期：2015-11-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). However, mechanisms by which CNTF expression could be increased in the brain are poorly understood. Recently we have discovered anti-inflammatory and immunomodulatory activities of sodium benz...

journal_title：Neurochemical research

authors： Modi KK,Jana M,Mondal S,Pahan K

更新日期：2015-11-01 00:00:00

abstract：:The adaptation of cells to hyperosmotic conditions involves accumulation of organic osmolytes to achieve osmotic equilibrium and maintenance of cell volume. The Na+ and Cl(-)-coupled betaine/GABA transporter, designated BGT-1, is responsible for the cellular accumulation of betaine and has been proposed to play a role...

journal_title：Neurochemical research

authors： Olsen M,Sarup A,Larsson OM,Schousboe A

更新日期：2005-06-01 00:00:00

abstract：:The participation of voltage-sensitive Na+ channels (VSSC) on the changes on internal (i) Na+, K+, Ca2+, and on DA, Glu, and GABA release caused by different concentrations of 4-AP was investigated in striatum synaptosomes. TTX, which abolished the increase in Na(i) (as determined with SBFI), induced by 0.1 mM 4-AP on...

journal_title：Neurochemical research

authors： Galván E,Sitges M

更新日期：2004-02-01 00:00:00

abstract：:Ingestion of ammonium induces hyperammonemia which increases tubulin content in cerebrum but not in cerebellum. We have dissected 11 discrete areas of cerebrum and quantified the tubulin content in control and hyperammonemic rats. An heterogeneity in the induction of tubulin is shown. The areas more affected are ventr...

journal_title：Neurochemical research

authors： Miñana MD,Felipo V,Quel A,Pallardó F,Grisolía S

更新日期：1989-12-01 00:00:00

abstract：:Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was ...

journal_title：Neurochemical research

authors： Uzbay IT,Usanmaz SE,Akarsu ES

更新日期：2000-02-01 00:00:00

abstract：:Menadione (2-methyl-1,4-naphthoquinone) is a synthetic derivative of vitamin K that allows rapid redox cycling in cells and thereby generates reactive oxygen species (ROS). To test for the consequences of a treatment of brain astrocytes with menadione, we incubated primary astrocyte cultures with this compound. Incuba...

journal_title：Neurochemical research

authors： Steinmeier J,Dringen R

更新日期：2019-05-01 00:00:00

abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...

journal_title：Neurochemical research

authors： Ivanov TR,Brown IR

更新日期：1989-02-01 00:00:00

abstract：:The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore established sensitive quantification methods and provided a rat ICH model for detection of ICH deterioration. In ICH intrastriatally induced by 0.014-unit, 0.070-unit, and 0.350-unit co...

journal_title：Neurochemical research

authors： Terai K,Suzuki M,Sasamata M,Miyata K

更新日期：2003-05-01 00:00:00

abstract：:The levels of selected neuroregulatory proteins that inhibit or promote apoptotic cell death were measured in the striatum of piglets subjected to precisely controlled 1 h hypoxic insult followed by 0, 2 and 4 h recovery and compared to sham operated animals. The anti-apoptotic proteins: there were increases in Surviv...

journal_title：Neurochemical research

authors： Mammen A,Kubin J,Greeley WJ,Schears GJ,Pastuszko P,F Wilson D,Pastuszko A

更新日期：2011-05-01 00:00:00

abstract：:Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain, many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, man...

journal_title：Neurochemical research

authors： Yi SS,Hwang IK,Kim DW,Shin JH,Nam SM,Choi JH,Lee CH,Won MH,Seong JK,Yoon YS

更新日期：2011-01-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces type I organophosphorus ester-induced delayed neurotoxicity in humans and sensitive animal species. This is accompanied by enhanced Ca2+/CaM-dependent protein kinase II (CaM-kinase II) activity, and [125I]calmodulin binding to CaM-kinase II in DFP-treated hen brain supern...

journal_title：Neurochemical research

authors： Gupta RP,Abou-Donia MB

更新日期：1993-03-01 00:00:00

abstract：:Recent evidence has linked striatal amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor function to the adverse effects of long-term dopaminergic treatment in Parkinson's disease. The phosphorylation of AMPA subunit, GluR1, reflects AMPA receptor activity. To determine whether serine phosphorylation of...

journal_title：Neurochemical research

authors： Ba M,Kong M,Yang H,Ma G,Lu G,Chen S,Liu Z

更新日期：2006-11-01 00:00:00

abstract：:Metformin is the most frequently used drug for the treatment of type 2 diabetes in humans. However, only little is known about effects of metformin on brain metabolism. To investigate potential metabolic consequences of an exposure of brain cells to metformin, we incubated rat astrocyte-rich primary cultures with this...

journal_title：Neurochemical research

authors： Westhaus A,Blumrich EM,Dringen R

更新日期：2017-01-01 00:00:00

abstract：:The Editors have retracted this article [1] following an investigation conducted by the journal. After publication concerns were raised regarding interpretation of the data presented in Fig. 4. The Editors requested additional data and clarification to confirm interpretation of data results. After further review, the ...

journal_title：Neurochemical research

authors： Zhang J,Liu Z,Pei Y,Yang W,Xie C,Long S

更新日期：2020-09-01 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...

journal_title：Neurochemical research

authors： Lanning CL,Wilmarth KR,Abou-Donia MB

更新日期：1994-09-01 00:00:00

abstract：:Post-ischemic changes in energy metabolites and natural antioxidant compounds have been measured in rat brain in vitro concurrent with two different assays for peroxidized lipids. No exogenous free radical initiators were employed. In vitro oxygenation of minced brain preparations for periods of 10 minutes to 4 hours,...

journal_title：Neurochemical research

authors： Kogure K,Watson BD,Busto R,Abe K

更新日期：1982-04-01 00:00:00

abstract：:Kainic acid-induced seizures produced early (2 hr) generalized edema and later (24 and 48 hr) necrotic edema in temporal cortex and hippocampus as measured by specific gravity changes. Mannitol given during the seizure partially protected against the early edema and prevented the necrotic edema indicating early edema ...

journal_title：Neurochemical research

authors： Nelson SR,Olson JP

更新日期：1987-06-01 00:00:00

abstract：:Mitochondrial dysfunction has been proposed to be one of the earliest triggering events in isoflurane-induced neuronal damage. Lidocaine has been demonstrated to attenuate the impairment of cognition in aged rats induced by isoflurane in our previous study. In this study, we hypothesized that lidocaine could attenuate...

journal_title：Neurochemical research

authors： Li J,Zhu X,Yang S,Xu H,Guo M,Yao Y,Huang Z,Lin D

更新日期：2019-07-01 00:00:00

abstract：:Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological ...

journal_title：Neurochemical research

authors： Sámano C,Nistri A

更新日期：2019-01-01 00:00:00

abstract：:The microdialysis technique was utilized to study the local effects of D1 and D2 family type dopamine (DA) receptor (R) ligands on the in vivo release of endogenous glutamate (GLU) and aspartate (ASP) from rat substantia nigra (SN). Addition to the dialysis perfusion solution of either D1-R and D2-R agonists, such as ...

journal_title：Neurochemical research

authors： Abarca J,Gysling K,Roth RH,Bustos G

更新日期：1995-02-01 00:00:00

abstract：:Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA si...

journal_title：Neurochemical research

authors： Peterson C,Héroux M,Lavoie J,Butterworth RF

更新日期：1995-10-01 00:00:00

abstract：:Sex differences exist in the functioning of the two brain corticosteroid receptor systems. Ovarian steroid replacement alters receptor mRNA expression, receptor binding capacities, and receptor affinity. The abundance of both mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) message can be reduced by es...

journal_title：Neurochemical research

authors： Turner BB

更新日期：1997-11-01 00:00:00

abstract：:Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such as ischemic stroke. In this study, we examined the neuroprotective effect of TsI against ischemic damage and its neuroprotective mecha...

journal_title：Neurochemical research

authors： Park JH,Park Ok,Cho JH,Chen BH,Kim IH,Ahn JH,Lee JC,Yan BC,Yoo KY,Lee CH,Hwang IK,Kwon SH,Lee YL,Won MH,Choi JH

更新日期：2014-07-01 00:00:00

abstract：:The three essential amino acids, valine, leucine and isoleucine, constitute the group of branched-chain amino acids (BCAAs). BCAAs are rapidly taken up into the brain parenchyma, where they serve several distinct functions including that as fuel material in brain energy metabolism. As one function of astrocytes is con...

journal_title：Neurochemical research

authors： Murín R,Mohammadi G,Leibfritz D,Hamprecht B

更新日期：2009-07-01 00:00:00

abstract：:Exposure to sevoflurane and other inhalational anesthetics can induce cognitive impairment in elderly patients. Studies have indicated that methylene blue (MB) has beneficial effects on multiple neurodegenerative diseases and the mechanism involves mitochondrial function preservation. However, whether MB can attenuate...

journal_title：Neurochemical research

authors： Zheng F,Fang P,Chang J,Chen M,Zhong Q,Chen T,Chen C,Zhang Z

更新日期：2020-04-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expressi...

journal_title：Neurochemical research

authors： Corona JC,Duchen MR

更新日期：2015-02-01 00:00:00