Abstract:
:Lesions of the nigrostriatal pathway are known to induce a compensatory up-regulation of various neurotrophic factors. In this study we examined protein content of basic fibroblast growth factor (FGF-2) in tissue samples taken from the ventral midbrain and striatum at two different time points following a neurotoxic lesion of the nigrostriatal pathway in two different rat strains, the outbred Sprague-Dawley (SD) and inbred F344 9 Brown Norway F1 hybrid (F344BNF1). Despite both rat strains having comparable lesions of the nigrostriatal pathway, we observed a difference in the temporal up-regulation of FGF-2 in ventral midbrain samples taken from the side ipsilateral to the lesion. Basic FGF was significantly upregulated in ventral midbrain in SD rats 1 week post-lesion while we did not observe an up-regulation of FGF-2 in the lesioned ventral midbrain of F344BNF1 at this same time point. However, both strains showed a significant up-regulation of FGF-2 in the lesioned ventral midbrain 3 weeks post-lesion. Sprague-Dawley rats also appeared to be more sensitive to the lesion in terms of up-regulating FGF-2 expression. The differences reported here suggest currently unknown genetic differences between these two strains may be important factors for regulating the compensatory release of neurotrophic factors, such as FGF-2, in response to a neurotoxic lesion of the nigrostriatal pathway.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Yurek DM,Fletcher AM,Peters LE,Cass WAdoi
10.1007/s11064-009-0093-7subject
Has Abstractpub_date
2010-04-01 00:00:00pages
531-9issue
4eissn
0364-3190issn
1573-6903journal_volume
35pub_type
杂志文章abstract::Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0639-3
更新日期:2012-03-01 00:00:00
abstract::The effects of a number of drugs that deplete catecholamines or block their receptors were investigated on the levels of free amino acids and glutamate decarboxylase activity in rat striatum and substantia nigra, in an attempt to clarify the possible links between catecholamine and amino acid transmitter function. Whi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966009
更新日期:1977-10-01 00:00:00
abstract::Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-006-9128-5
更新日期:2007-04-01 00:00:00
abstract::Apoptotic cell death pathways have been implicated in acute brain injuries, including cerebral ischemia, brain trauma, and spinal cord injury, and in chronic neurodegenerative diseases. Experimental ischemia and reperfusion models, such as transient focal/global ischemia in rodents, have been thoroughly studied and su...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-004-6869-x
更新日期:2004-11-01 00:00:00
abstract::The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0412-7
更新日期:2011-05-01 00:00:00
abstract::The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal we...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1889-x
更新日期:2016-07-01 00:00:00
abstract::Level of adenosine, an endogenous astrocyte-based neuromodulator, is primarily regulated by adenosine P1 receptors. This study assessed expression of adenosine P1 receptors, ADORA1 (adenosine A1 receptor) and ADORA2A (adenosine A2a receptor) and their association with glioma development and epilepsy in glioma patients...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1893-1
更新日期:2016-07-01 00:00:00
abstract::Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020716304520
更新日期:1998-08-01 00:00:00
abstract::Glutamine synthetase (GS) is the major glutamine-forming enzyme of vertebrates and is accepted to be a marker of astroglial cells. Maturation of astroglial cells is characterized by an increase of GS activity, and the regulation of this enzyme is the topic of many publications. Because of the fundamental role of the G...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-2754-5
更新日期:2005-05-01 00:00:00
abstract::Neuronal excitation leads to an increase of the extracellular K(+) concentration ([K(+)]o) in brain. This increase has at least two energy-consuming consequences: (1) a depolarization-mediated change in intracellular pH (pHi) in astrocytes due to depolarization-mediated increased activity of the acid-extruding Na(+)/b...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1149-2
更新日期:2013-11-01 00:00:00
abstract::Subunit-specific antibodies to all the gamma subunit isoforms described in mammalian brain (gamma(1), gamma(2S), gamma(2L), and gamma(3) have been made. The proportion of GABA(A) receptors containing each gamma subunit isoform in various brain regions has been determined by quantitative immunoprecipitation. In all tes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02529132
更新日期:1996-02-01 00:00:00
abstract::We propose the following scheme for cerebral uptake and overall metabolism of glucose in vivo: that brain selects from two pools of glucose anomers in arterial blood, that it takes up excess glucose, that glucose enters the brain tissue as glucose-6-phosphate through the actions of mutarotase and hexokinase, that some...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964568
更新日期:1985-02-01 00:00:00
abstract::Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children, with hyperoxia (HHI) treatment being a clinical therapy for newborn resuscitation. Although cerebral edema is a common outcome after HI, the mechanisms leading to excessive fluid accumu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0308-y
更新日期:2010-12-01 00:00:00
abstract::Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021670607647
更新日期:2002-12-01 00:00:00
abstract::Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is recovered as the free aminoacid within...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9418-6
更新日期:2008-01-01 00:00:00
abstract::Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007579705230
更新日期:2000-02-01 00:00:00
abstract::Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02532417
更新日期:1996-09-01 00:00:00
abstract::Brain noradrenergic system has been implicated in early-life stress effects on adult physiology and behavior; however, the mechanisms for this relationship are not clear. Here we tested the hypothesis that stress hormones, glucocorticoids, may affect noradrenergic system activity by modulating gene expression and func...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0676-y
更新日期:2012-04-01 00:00:00
abstract::The Src family kinases are a family of intracellular, non-receptor tyrosine kinases that are involved in a variety of cellular functions including the regulation of inflammation and apoptosis after brain hypoxia. Caspase-1 (C1) activates IL-1β through the formation of complex structures, the inflammasomes, while caspa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1717-8
更新日期:2015-11-01 00:00:00
abstract::Oxidative stress can induce neuronal apoptosis via the production of superoxide and hydroxyl radicals. This process is as a major pathogenic mechanism in neurodegenerative disorders. In this study, we aimed to clarify whether theaflavins protect PC12 cells from oxidative stress damage induced by H2O2. A cell model of ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2069-8
更新日期:2016-12-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The spelling of the author Tommaso Ianniti was incorrect and has been corrected as Tommaso Iannitti. The original article has been corrected. ...
journal_title:Neurochemical research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11064-018-2468-0
更新日期:2018-02-01 00:00:00
abstract::Selective blockade of a subset of GABA(A) receptors may be involved in the antipsychotic effects of Clozapine and several other antipsychotic drugs. Seven antipsychotic drugs, and 11 drugs classified as antidepressants that only partially reverse the inhibitory effect of 1 microM GABA on [35S]TBPS binding, do not yiel...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1027359422433
更新日期:1997-02-01 00:00:00
abstract::Three peptides overlapping the tryptophan region of bovine CNS myelin basic protein were synthesized by the solid phase procedure of Merrifield. These were the nonapeptide H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, the octapeptide H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, and the heptapeptide H-Trp-Gly-Ala-Glu-Gly-Gln-Lys-...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964458
更新日期:1980-01-01 00:00:00
abstract::This study was designed to investigate the protective effects of extracellular superoxide dismutase (SOD3) against hydrogen peroxide (H2O2) induced damage in human neuroblastoma SH-SY5Y cells and to elucidate the mechanisms responsible for this beneficial effect. SOD3-overexpressing SH-SY5Y cells were generated by ade...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1897-x
更新日期:2016-07-01 00:00:00
abstract::Insulin-like growth factor 1 (IGF-1) stimulates α-secretase processing of amyloid precursor protein (APP) and decreases Aβ production. Little is known about the relationship between IGF-1 and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1), the protease essential for the production of β-amyloid peptides (A...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0260-x
更新日期:2011-01-01 00:00:00
abstract::The effects of 1 min of acute hypoxic treatment (1% O2 in N2) on incorporation of [1-14C]arachidonic acid into brain lipids of 16-day-old rats were investigated at 3, 6, and 12 min after intracerebral injection of the labeled fatty acid. The hypoxic-hypoxia condition associated with convulsive seizures caused a decrea...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965474
更新日期:1981-07-01 00:00:00
abstract::We evaluated oxidative stress associated with a model of experimental epilepsy. Male Wistar rats were injected i.p. with 150 mg/kg convulsant 3-mercaptopropionic acid and decapitated in two stages: during seizures or in the post-seizure period. Spontaneous chemiluminescence, levels of thiobarbituric acid reactive subs...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF03177490
更新日期:1998-12-01 00:00:00
abstract::S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9915-x
更新日期:2009-08-01 00:00:00
abstract::Hypoglycemia is the major problem to blood glucose homeostasis in treatment of diabetes and is associated with severe irreversible consequences including seizures, coma and death. GABAergic inhibitory function in the cerebral cortex plays an important role in controlling the excitability and responsiveness of cortical...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0210-7
更新日期:2010-10-01 00:00:00
abstract::Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9311-3
更新日期:2007-08-01 00:00:00