Abstract:
:Apoptotic cell death pathways have been implicated in acute brain injuries, including cerebral ischemia, brain trauma, and spinal cord injury, and in chronic neurodegenerative diseases. Experimental ischemia and reperfusion models, such as transient focal/global ischemia in rodents, have been thoroughly studied and suggest the involvement of mitochondria and the cell survival/death signaling pathways in cell death/survival cascades. Recent studies have implicated mitochondria-dependent apoptosis involving pro- and antiapoptotic protein binding, the release of cytochrome c and second mitochondria-derived activator of caspase, the activation of downstream caspases-9 and -3, and DNA fragmentation. Reactive oxygen species are known to be significantly generated in the mitochondrial electron transport chain in the dysfunctional mitochondria during reperfusion after ischemia, and are also implicated in the survival signaling pathway that involves phosphatidylinositol-3-kinase (PI3-K), Akt, and downstream signaling molecules, like Bad, 14-3-3, and the proline-rich Akt substrate (PRAS), and their bindings. Further studies of these survival pathways may provide novel therapeutic strategies for clinical stroke.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Chan PHdoi
10.1007/s11064-004-6869-xkeywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1943-9issue
11eissn
0364-3190issn
1573-6903journal_volume
29pub_type
杂志文章,评审abstract::A study was undertaken in rats to evaluate the effects of short-term oral ethanol administration on the levels of fatty acid ethyl esters (FAEE) in brain and peripheral organs in the presence and absence of pretreatment with L-carnitine. Administration of ethanol to rats for seven days resulted in fatty acid ethyl est...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020984114824
更新日期:1999-01-01 00:00:00
abstract::T-588(R(-)-1-(benzo(b)thiophen-5yl)-2-[2(N,N-diethylamino)ethoxy]ethanol hydrochloride) is a novel compound which has been shown to exhibit a wide range of neurotrophic effects both in vivo and in vitro. This compound can slow the motor deterioration of wobbler mouse motor neuron disease. However, it is not known whet...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1014884504879
更新日期:2002-03-01 00:00:00
abstract::To evaluate the influence of light and darkness on brain pyroglutamyl-peptidase I (pGluPI) activity, four experimental groups of rats were compared at the same time-point (10.00 h). Two groups were designed with a standard 12-12 h light-dark cycle: In group A, the lights were on from 7.00 h to 19.00 h, and the experim...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1010996425408
更新日期:2001-05-01 00:00:00
abstract::Hypothalamic and plasma dopamine-beta-hydroxylase [DBH, EC 1.14.2.1] activites were measured by a coupled radioenzymatic method. Animals representing five experimental groups [intact controls, adrenalectomized, pinealectomized, adrenalectomized pinealectomized, doubly sham-operated] were killed and sampled at 8 times ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965575
更新日期:1978-06-01 00:00:00
abstract::Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specif...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966702
更新日期:1991-11-01 00:00:00
abstract::We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF02527711
更新日期:1996-04-01 00:00:00
abstract::Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark-light transition. The rhythmic cycling pattern of Chordc1 was retained under various light-d...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9271-z
更新日期:2007-02-01 00:00:00
abstract::Status epilepticus (SE) is a severe clinical manifestation of epilepsy associated with intense neuronal loss and inflammation, two key factors involved in the pathophysiology of temporal lobe epilepsy. Bone marrow mononuclear cells (BMMC) attenuated the consequences of pilocarpine-induced SE, including neuronal loss, ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1217-7
更新日期:2014-02-01 00:00:00
abstract::The present studies examined the inhibitory effect of veratridine (a Na+ channel activator) on carbachol (a cholinergic agonist) stimulated inositol 1,3,4,5-tetrakisphosphate accumulation in rat brain cortical slices. Veratridine inhibited carbachol stimulation of inositol 1,3,4,5-tetrakisphosphate formation (after a ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00995560
更新日期:1995-09-01 00:00:00
abstract::In this communication, the effect of acute treatment with lamotrigine (LTG) was investigated on release of main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-induced and PTZ-kindled freely moving rats using micro dialysis. The results show that, ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0942-7
更新日期:2013-03-01 00:00:00
abstract::The mechanism of focal demyelination in multiple sclerosis has been a long-standing enigma of this disorder. Cytokines, a diverse family of signalling molecules, are viewed as potential mediators of the process based on clinical observations and studies with animal models and tissue/cell culture systems. Myelin and ol...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022493013904
更新日期:1998-03-01 00:00:00
abstract::Recent evidence suggests that young rodents submitted to high fructose (FRU) diet develop metabolic, and cognitive dysfunctions. However, it remains unclear whether these detrimental effects of FRU intake can also be observed in middle-aged mice. Nine months-old C57BL/6 female mice were fed with water (Control) or 10%...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03135-7
更新日期:2020-12-01 00:00:00
abstract::We investigated the ability of hydrogen peroxide (H2O2) to cause apoptotic cell death in cultured rat forebrain neurons and the potential mechanisms by which oxidative stress triggers delayed neuronal death. H2O2 (25 microM for 5 min) reduced cell viability to 34.5 +/- 8.3% of untreated controls 20 h after exposure, a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022403224901
更新日期:1997-03-01 00:00:00
abstract::The pathophysiological mechanism(s) underlying Alzheimer's disease (AD) still remain unclear, and no disease-modifying or prophylactic therapies are currently available. Unraveling the fundamental neuropathogenesis of AD is an important challenge. Several studies on AD have suggested lesions in a number of CNS areas i...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-011-0680-2
更新日期:2012-04-01 00:00:00
abstract::Acupuncture and moxibustion are traditional medical treatments that have come to play important roles in complementary and alternative medicines. Moxibustion also has a long history as a folk remedy in Japan, particularly due to the technical simplicity and selective efficacy on certain types of disease and distress. ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-8839-3
更新日期:2005-12-01 00:00:00
abstract::During the past decade a new approach to pathogenetic studies of hepatic encephalopathy has been undertaken to identify the neurochemical alterations which characterize the syndrome. Using animal models of hepatic encephalopathy electrophysiological, behavioral, pharmacological and biochemical evidence were provided o...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF00972205
更新日期:1990-02-01 00:00:00
abstract::We have shown that acute ammonia toxicity is mediated by activation of the NMDA type of glutamate receptors. Although it is well known that L-carnitine prevents acute ammonia toxicity, the underlying molecular mechanism is not clear. We suspected that L-carnitine would prevent ammonia toxicity by preventing the toxic ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971588
更新日期:1994-03-01 00:00:00
abstract::Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022413718447
更新日期:1998-03-01 00:00:00
abstract::We have utilized quantitative autoradiography with the GABA(A) receptor chloride channel blocker [35S]t-butylbicyclophosphorothionate ([35S]TBPS) in rodent brain sections to investigate if differential proton modulation of various GABA(A) receptor subtypes expressed in various brain regions are differentially sensitiv...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000018849.54169.c4
更新日期:2004-04-01 00:00:00
abstract::Sex differences exist in the functioning of the two brain corticosteroid receptor systems. Ovarian steroid replacement alters receptor mRNA expression, receptor binding capacities, and receptor affinity. The abundance of both mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) message can be reduced by es...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022023207326
更新日期:1997-11-01 00:00:00
abstract::cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold or greater difference in normalized expression. RT-PCR analysis of a s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1026179926780
更新日期:2003-12-01 00:00:00
abstract::The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal we...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1889-x
更新日期:2016-07-01 00:00:00
abstract::The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines. VRI protein was de...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000018839.59457.5c
更新日期:2004-04-01 00:00:00
abstract::Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei iso...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965136
更新日期:1982-08-01 00:00:00
abstract::Chemotherapy drugs such as vincristine (VCR) can cause neuropathic pain, and there is still lack of ideal strategy to treat it. The current study was designed to investigate effect of matrine (MT) on VCR-induced neuropathic pain in animal model. VCR (75 μg/kg, i.p. for 10 consecutive days) was administered to induce p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2040-8
更新日期:2016-11-01 00:00:00
abstract::The release of labeled norepinephrine from preloaded synaptosomes requires the presence of potassium and calcium. ATP-dependent binding of calcium to synaptic plasma membranes (SPM) may provide a means of maintaining the cation in a readily available pool for the triggering of transmitter release. A high Ca-binding ca...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965106
更新日期:1983-04-01 00:00:00
abstract::Suspensions of rat brain microsomes, synaptosomes, and synaptic vesicles were able to convert adenosine to inosine by means of adenosine deaminase. Isosbestic points of this transformation, at 222, 250 and 281 nm, remained unchanged with time-course. This fact suggests that adenosine deaminase (ADA, E.C. 3.5.4.4) is l...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965316
更新日期:1986-04-01 00:00:00
abstract::Plasmalogens are ether-linked phospholipids that are abundant in nervous tissues. Their biological role is unclear, but may involve membrane structure/function and antioxidant activities. This study further investigates a recent report that chronic administration of myo-inositol in rats increased brain phosphatidyleth...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000018859.23881.f9
更新日期:2004-04-01 00:00:00
abstract::In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract::In the present study, we evaluated the expression of some proliferation and differentiation markers in 15 DIV astrocyte cultures pretreated or not with 0.5 mM glutamate for 24 h and than maintained under chronic or acute treatment with 50 μM R(+)enantiomer or raceme alpha-lipoic acid (ALA). GFAP expression significant...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0256-6
更新日期:2010-12-01 00:00:00