Abstract:
:Insulin-like growth factor 1 (IGF-1) stimulates α-secretase processing of amyloid precursor protein (APP) and decreases Aβ production. Little is known about the relationship between IGF-1 and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1), the protease essential for the production of β-amyloid peptides (Aβ). Here, we investigated the effect of IGF-1 on BACE-1 in PC12 cells. Quantitative polymerase chain reaction analysis and western blot showed that treatment of cells with IGF-1 significantly decreased the levels of BACE-1 mRNA and protein. Furthermore, IGF-1 increased the phosphorylation of Akt and ERK1/2. The presence of the phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002 and the mitogen-activated protein kinase kinases (MEK) inhibitor PD98059 blocked the effect of IGF-1 on BACE-1. Our data indicated that IGF-1-induced reduction of BACE-1 might involve the PI3-K/Akt and MAPK/ERK1/2 signaling pathways.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Zhang H,Gao Y,Dai Z,Meng T,Tu S,Yan Ydoi
10.1007/s11064-010-0260-xsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
49-57issue
1eissn
0364-3190issn
1573-6903journal_volume
36pub_type
杂志文章abstract::NMDA, the specific agonist of glutamate gated ion channels permeable to calcium, is implicated as a causal factor in the pathogenesis of several neurobiological disorders such as stroke, seizures, ischemia, and chronic neurodegenerative diseases. On the other hand, evidence on the roles of oxidative mechanisms involve...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02533102
更新日期:1996-12-01 00:00:00
abstract::Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021670607647
更新日期:2002-12-01 00:00:00
abstract::Altered neurogenesis has been reported in Alzheimer disease (AD), the most common neurodegenerative disorder characterized with hyperphosphorylated tau and accumulation of β-amyloid (Aβ). Recent studies suggest that tau phosphorylation is essential for hippocampal neurogenesis, however, it is not known whether tau pho...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0316-y
更新日期:2011-02-01 00:00:00
abstract::Impaired glucose transport across brain tissue barriers causes infantile seizures, developmental delay and acquired microcephaly. Since the first report in 1991 (De Vivo et al, NEJM, 1991) 17 patients have been identified with the glucose transporter protein syndrome (GTPS). The diagnostic feature of the syndrome is a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022544131826
更新日期:1999-04-01 00:00:00
abstract::The binding of [3H]ethylketocyclazocine ([3H]EKC) under the suppression of mu and delta sites in the brain of EL mice (seizure-susceptible) was examined to determine the relationship between seizures and the dynorphinergic system. The density of kappa-opioid receptors in the cerebrum of adult EL mice during interictal...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022424707543
更新日期:1998-02-01 00:00:00
abstract::Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following inhaled anesthetics treatment can perturb cerebral homeostasis, which may be associated with their induced neurotoxicity. Seven-day-old rat ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1529-x
更新日期:2015-04-01 00:00:00
abstract::The significant increase of free calcium concentration ([Ca2+]i) was found in rat cerebral cortex synaptosomes and hippocampal crude synaptosomal fraction after their exposure to glutamate. But no change of [Ca2+]i was revealed in cerebellar synaptosomes, the slight increase of [Ca2+]i in striatal synaptosomes was not...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020752101736
更新日期:1999-09-01 00:00:00
abstract::A cortical cup model with continuous perfusion of artificial cerebrospinal fluid (containing 134 mM NaCl) was used to investigate the effects of anion channel blockers on the hyposmotically-induced release of amino acids from the in vivo rat cerebral cortex. The hyposmotic stimulus (25 mM NaCl) evoked a release of tau...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020902104056
更新日期:1999-03-01 00:00:00
abstract::Harpagophytum procumbens, popularly known as devil's claw, is a plant commonly used in the treatment of diseases of inflammatory origin. The anti-inflammatory effects of H. procumbens have been studied; however, the mechanism of action is not elucidated. It is known that excess of reactive oxygen and nitrogen species ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1133-x
更新日期:2013-11-01 00:00:00
abstract::Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in re...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965332
更新日期:1986-05-01 00:00:00
abstract::The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebe...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1027345808746
更新日期:1997-06-01 00:00:00
abstract::The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965738
更新日期:1990-10-01 00:00:00
abstract::Mitochondrially bound brain hexokinase is solubilized by anesthetics and this effect has been suggested to contribute to anesthesia. In the present investigation the influence of the metabolic inhibitor 2-deoxy-D-glucose (2-DOG) was studied. An isolated rat brain preparation was used to avoid the contribution of perip...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965526
更新日期:1982-06-01 00:00:00
abstract::Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for ty...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0433-2
更新日期:2011-09-01 00:00:00
abstract::A study was undertaken in rats to evaluate the effects of short-term oral ethanol administration on the levels of fatty acid ethyl esters (FAEE) in brain and peripheral organs in the presence and absence of pretreatment with L-carnitine. Administration of ethanol to rats for seven days resulted in fatty acid ethyl est...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020984114824
更新日期:1999-01-01 00:00:00
abstract::Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippocampus and brainstem are involved in affective disorders. Sodium-potassium/ATPase is of paramount importance for the proper functioning of the brain and its involvement in the affective disorders has been claimed for a l...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9046-6
更新日期:2006-04-01 00:00:00
abstract::"Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model of temporal lobe epilepsy. At the present work we investigated the contribution of NMDA receptors in the Pentylenetetrazol-induced "kindling" model in the mouse brain, by using quantitative autoradiography and the radioa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021143813935
更新日期:1999-12-01 00:00:00
abstract::Treatment of neural membranes from rat cerebral cortex with phospholipase C (phosphatidylcholine cholinephosphohydrolase) inhibited the binding of radiolabelled antagonists to muscarinic acetylcholine receptors. This inhibition was incomplete, was not competitive, and did not appear to be related to the production of ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964517
更新日期:1984-05-01 00:00:00
abstract::Brief limb ischemia was reported to protect neurons against injury induced by subsequent cerebral ischemia-reperfusion, and this phenomenon is known as limb ischemic preconditioning (LIP). To explore the role of nitric oxide (NO) in neuroprotection of LIP in rats, we observed changes in the content of nitric oxide (NO...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9381-2
更新日期:2007-11-01 00:00:00
abstract::Recent evidence suggests that young rodents submitted to high fructose (FRU) diet develop metabolic, and cognitive dysfunctions. However, it remains unclear whether these detrimental effects of FRU intake can also be observed in middle-aged mice. Nine months-old C57BL/6 female mice were fed with water (Control) or 10%...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03135-7
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0203-6
更新日期:2010-09-01 00:00:00
abstract::Cerebral blood flow (CBF) and cerebellar blood flow (CeBF) were measured and correlated with brain lactate, pyruvate and adenosine triphosphate concentrations from groups representing 3-week old suckling (n = 10), 18-22-week old adult (n = 9) and 70-week old aged (n = 7) Sprague-Dawley rats before and during bilateral...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1027321203294
更新日期:1997-01-01 00:00:00
abstract::The effect of optic nerve transsection on proteolytic degradation of axonally transported proteins in the superior colliculus of the rabbit was studied. Proteolysis of labeled proteins was determined in vitro in small pieces of the superior colliculus. Within 2 hours after sectioning the optic nerve there was a decrea...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973280
更新日期:1988-07-01 00:00:00
abstract::It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists between myelination, the commonly studied function of oligodendrocytes, and that of transferrin synthesis and se...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-004-1826-2
更新日期:1999-02-01 00:00:00
abstract::There is a growing body of evidence confirming the involvement of oxidative stress and inflammation in pathogenesis of schizophrenia. Inter-individual variation in antioxidant capacity caused by different genetic profile could potentially influence patient's susceptibility to oxidative damage. In this study we evaluat...
journal_title:Neurochemical research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11064-012-0937-4
更新日期:2013-02-01 00:00:00
abstract::It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000035800.65411.3e
更新日期:2004-09-01 00:00:00
abstract::Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1729-4
更新日期:2015-10-01 00:00:00
abstract::Oxidative stress is one of the most important pathological mechanisms in neurodegenerative diseases and ischemia. Recent studies have indicated that the sonic hedgehog (SHH) signaling pathway is involved in these diseases, but the underlying mechanisms remains elusive. Here we report that the SHH pathway was activated...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0264-6
更新日期:2011-01-01 00:00:00
abstract::The effects of 1 min of acute hypoxic treatment (1% O2 in N2) on incorporation of [1-14C]arachidonic acid into brain lipids of 16-day-old rats were investigated at 3, 6, and 12 min after intracerebral injection of the labeled fatty acid. The hypoxic-hypoxia condition associated with convulsive seizures caused a decrea...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965474
更新日期:1981-07-01 00:00:00
abstract::Trigeminal neuralgia (TN) is a type of chronic neuropathic pain that is caused by peripheral nerve lesions that result from various conditions, including the compression of vessels, tumors and viral infections. MicroRNAs (miRs) are increasingly recognized as potential regulators of neuropathic pain. Previous evidence ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02797-2
更新日期:2019-07-01 00:00:00