Abstract：
:The binding of [3H]ethylketocyclazocine ([3H]EKC) under the suppression of mu and delta sites in the brain of EL mice (seizure-susceptible) was examined to determine the relationship between seizures and the dynorphinergic system. The density of kappa-opioid receptors in the cerebrum of adult EL mice during interictal periods significantly increased, without changes in apparent affinities, compared with that of adult ddY mice (seizure-nonsusceptible; the mother strain of EL). Subsequently, the binding of 0.8 nM [3H]EKC in 8 brain regions was examined in the 2 strains. The [3H]EKC binding in 25-day-old EL mice that had no seizures significantly increased in the hippocampus and amygdala. At the age of 50 days, EL mice displayed abortive seizures, and the number of kappa sites in EL mice was significantly greater in the hippocampus, amygdala and cerebral cortex. It was further shown that the binding of [3H]EKC in 150-day-old adult EL mice during interictal periods was markedly increased in the hippocampus, amygdala, cerebral cortex and striatum, compared with the corresponding regions in ddY mice. The up-regulation of kappa receptors in the EL mouse brain may result from deficits in endogenous dynorphins, which could be involved in the pathogenesis of seizure diathesis and seizure manifestations in the EL mouse.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Kai T,Onishi H,Koide S,Katayama M,Yamagami Sdoi
10.1023/a:1022424707543subject
Has Abstractpub_date
1998-02-01 00:00:00pages
163-8issue
2eissn
0364-3190issn
1573-6903journal_volume
23pub_type
杂志文章abstract：:Pathogens such as bacterial lipopolysaccharide (LPS) play an important role in promoting the production of the inflammatory cytokines interleukin-1 beta (IL-1β) and tumour necrosis factor-α (TNF-α) in response to infection or damage in microglia. However, whether different signalling pathways regulate these two inflam...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02895-1
更新日期：2019-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965622
更新日期：1989-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1985-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966670
更新日期：1992-03-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2094-7
更新日期：2017-02-01 00:00:00
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doi：10.1007/s11064-013-1206-x
更新日期：2014-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1024280429036
更新日期：2003-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00966071
更新日期：1982-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1983-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967712
更新日期：1994-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00993270
更新日期：1992-09-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0323-z
更新日期：2010-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0927-6
更新日期：2013-02-01 00:00:00
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journal_title：Neurochemical research
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journal_title：Neurochemical research
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pub_type： 杂志文章,评审
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journal_title：Neurochemical research
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更新日期：1994-01-01 00:00:00
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更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-04-01 00:00:00
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更新日期：2014-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9830-6
更新日期：2009-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00974871
更新日期：1991-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973750
更新日期：1990-06-01 00:00:00
abstract：:Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain, many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, man...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0280-6
更新日期：2011-01-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2003-05-01 00:00:00
