Incorporation of [3H]ethanolamine into acetylcholine by a human cholinergic neuroblastoma clone.

abstract：:Sonic hedgehog (Shh), a secreted glycoprotein factor, can activate the Shh pathway, which has been implicated in neuronal polarization involving neurite outgrowth. However, little evidence is available about the effect of Shh on neurite outgrowth in primary cortical neurons and its potential mechanism. Here, we reveal...

journal_title：Neurochemical research

authors： He W,Cui L,Zhang C,Zhang X,He J,Xie Y

更新日期：2016-04-01 00:00:00

abstract：:The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...

journal_title：Neurochemical research

authors： Giacobini E

更新日期：2003-04-01 00:00:00

abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...

journal_title：Neurochemical research

authors： Schousboe A,Larsson OM,Seiler N

更新日期：1986-11-01 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is a neurovisceral disorder characterized by lysosomal sequestration of endocytosed LDL-cholesterol, premature and abnormal enrichment of cholesterol in trans Golgi cisternae and accompanying anomalies in intracellular sterol trafficking. In addition to cholesterol, the NPC lesion has...

journal_title：Neurochemical research

authors： Vanier MT

更新日期：1999-04-01 00:00:00

abstract：:The developmental profiles of acetylcholinesterase and choline acetyltransferase in chick optic tectum and retina cell aggregates, over a 30-day period, have been determined and compared with the corresponding developmental curves obtained in vivo. Both acetylcholinesterase and choline acetyltransferase activities in ...

journal_title：Neurochemical research

authors： Ramirez G

更新日期：1977-08-01 00:00:00

abstract：:Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural ...

journal_title：Neurochemical research

authors： Ijomone OK,Shallie PD,Naicker T

更新日期：2020-04-01 00:00:00

abstract：:A previously described inhibitor of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyltransferase (GalNAc-T) (Quiroga et al., 1, 2), was purified from chicken blood serum by a new procedure. When subjected to SDS-PAGE, two major polypeptides of 27 and 70 kDa were observed. When tested in vitro, only the 27 kDa...

journal_title：Neurochemical research

authors： Conde CB,Grabois VR,Deza SN,Caputto BL

更新日期：1997-04-01 00:00:00

abstract：:Apoptosis is a highly complex form of cell death that can be triggered by alterations in Ca(2+) homeostasis. Members of the Bcl-2 family may regulate apoptosis and modulate Ca(2+) distribution within intracellular compartments. Bax, a proapoptotic member of the family, is constitutively expressed and soluble in the cy...

journal_title：Neurochemical research

authors： Morales AP,Carvalho AC,Monteforte PT,Hirata H,Han SW,Hsu YT,Smaili SS

更新日期：2011-05-01 00:00:00

abstract：:Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to inv...

journal_title：Neurochemical research

authors： Zhou X,Cheng H,Xu D,Yin Q,Cheng L,Wang L,Song S,Zhang M

更新日期：2014-11-01 00:00:00

abstract：:Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specif...

journal_title：Neurochemical research

authors： Freysz L,Farooqui AA,Horrocks LA,Massarelli R,Dreyfus H

更新日期：1991-11-01 00:00:00

abstract：:Members of the PDGF family have multiple roles during embryogenesis and in a variety of pathological situations in the adult. One of the major sites of PDGF-B expression in adult mammals are postmitotic CNS neurons. Combined with reported neurotrophic and neuroprotective effects of exogenously administered PDGFs, this...

journal_title：Neurochemical research

authors： Enge M,Wilhelmsson U,Abramsson A,Stakeberg J,Kühn R,Betsholtz C,Pekny M

更新日期：2003-02-01 00:00:00

abstract：:In the present paper we describe the presence in avian CNS of an endogenous inhibitor of [3H]flunitrazepam binding. This compound was extracted from a synaptic membrane fraction isolated from chick optic lobe and brain using an exhaustive aqueous washing procedure, then purified by means of solid-phase extraction with...

journal_title：Neurochemical research

authors： Gravielle MC,Peña C,Pignataro L,Fiszer de Plazas S

更新日期：1998-11-01 00:00:00

abstract：:Using the replication-defective adenovirus vector, we overexpressed rat glia maturation factor (GMF) in primary astrocyte cultures derived from embryonic rat brains. Among the three isoforms of MAP kinase, there was a big increase in the phosphorylation of p38, as detected with Western blotting using the phosphospecif...

journal_title：Neurochemical research

authors： Zaheer A,Yorek MA,Lim R

更新日期：2001-12-01 00:00:00

abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...

journal_title：Neurochemical research

authors： Hao G,Dong Y,Huo R,Wen K,Zhang Y,Liang G

更新日期：2016-06-01 00:00:00

abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...

journal_title：Neurochemical research

authors： Meyer EM,Otero DH

更新日期：1989-02-01 00:00:00

abstract：:The vesicular hypothesis has stimulated fruitful investigations on many secreting systems. In the case of rapid synaptic transmission, however, the hypothesis has been found difficult to reconcile with a number of well established observations. Brief impulses of transmitter molecules (quanta) are emitted from nerve te...

journal_title：Neurochemical research

authors： Dunant Y,Israël M

更新日期：1998-05-01 00:00:00

abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...

journal_title：Neurochemical research

authors： Long Y,Zhuang K,Ji Z,Han Y,Fei Y,Zheng W,Song Z,Yang H

更新日期：2019-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology,...

journal_title：Neurochemical research

authors： Xu CJ,Wang JL,Jin WL

更新日期：2016-06-01 00:00:00

abstract：:During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...

journal_title：Neurochemical research

authors： Brown CH,Brunton PJ,Russell JA

更新日期：2008-04-01 00:00:00

abstract：UNLABELLED:Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive...

journal_title：Neurochemical research

authors： Talarowska M,Gałecki P,Maes M,Bobińska K,Kowalczyk E

更新日期：2012-08-01 00:00:00

abstract：:Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...

journal_title：Neurochemical research

authors： Quay WB

更新日期：1989-10-01 00:00:00

abstract：:The kinetics and specificity of taurine and beta-alanine uptake were studied in primary cultures of rat astrocytes under identical experimental conditions. The uptake consisted of nonsaturable penetration and saturable high-affinity transport that was strictly sodium dependent. The cells accumulated taurine more effec...

journal_title：Neurochemical research

authors： Holopainen I,Kontro P

更新日期：1986-02-01 00:00:00

abstract：:In the present study, we aimed to investigate the effects of pinealectomy and chronic melatonin administration on focal epileptiform activity induced by penicillin in the rat cortex and to determine the relation between melatonin levels and electrocorticogram (ECoG) power spectrum. For this purpose, male Sprague-Dawle...

journal_title：Neurochemical research

authors： Yildirim M,Aydin-Abidin S,Abidin I,Akca M,Canpolat S,Cansu A

更新日期：2013-08-01 00:00:00

abstract：:We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...

journal_title：Neurochemical research

authors： Simzar S,Ellyin R,Shau H,Sarafian TA

更新日期：2000-12-01 00:00:00

abstract：:Ketogenic diet (KD) has been shown to be beneficial in a range of neurological disorders, with ketone metabolite β-hydroxybutyrate (βOHB) reported to block the nucleotide oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in bone marrow-derived macrophages. In this study, we sh...

journal_title：Neurochemical research

authors： Kong G,Liu J,Li R,Lin J,Huang Z,Yang Z,Wu X,Huang Z,Zhu Q,Wu X

更新日期：2020-10-27 00:00:00

abstract：:Zonisamide (ZNS), an antiepileptic drug having beneficial effects also against Parkinson's disease symptoms, has proven to display an antioxidant effects in different experimental models. In the present study, the effects of ZNS on rotenone-induced cell injury were investigated in human neuroblastoma SH-SY5Y cells dif...

journal_title：Neurochemical research

authors： Condello S,Currò M,Ferlazzo N,Costa G,Visalli G,Caccamo D,Pisani LR,Costa C,Calabresi P,Ientile R,Pisani F

更新日期：2013-12-01 00:00:00

abstract：:Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...

journal_title：Neurochemical research

authors： Florian CL,Williams SR,Bhakoo KK,Noble MD

更新日期：1996-09-01 00:00:00

abstract：:Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMD...

journal_title：Neurochemical research

authors： Ghiani CA,Beltran-Parrazal L,Sforza DM,Malvar JS,Seksenyan A,Cole R,Smith DJ,Charles A,Ferchmin PA,de Vellis J

更新日期：2007-02-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...

journal_title：Neurochemical research

authors： Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian AS

更新日期：1998-06-01 00:00:00

abstract：:Evidence is presented in support of the working hypothesis that "prenervous" neurotransmitters directly participate in cell-cell interactions occurring during the first several cleavage divisions of sea urchin embryos, a function which may occur during the early development of higher animals as well. This intercellula...

journal_title：Neurochemical research

authors： Buznikov GA,Shmukler YB

更新日期：1981-01-01 00:00:00