Abstract:
:The monoclonal antibody 14E immunocytochemically stains the nuclear membrane of oligodendrocytes but not myelin in tissue sections of adult normal human white matter. The nuclear membranes of Schwann cells in human peripheral nerve and cerebellar Bergmann glia were also visualized with this antibody. In actively demyelinating multiple sclerosis plaques the 14E antibody stained increased numbers of oligodendrocytes and the nuclei, perikarya and cell processes of hypertrophic glia, which were often multinucleate. Scattered small groups of these hypertrophic glia were present in areas of dense astrogliosis in acute plaques. The 14E-positive hypertrophic cells could be either a subpopulation of reactive astrocytes or bipotential glial precursors.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Newcombe J,Naik N,Cuzner MLdoi
10.1007/BF00993270keywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
933-8issue
9eissn
0364-3190issn
1573-6903journal_volume
17pub_type
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