Abstract：
:Although nitric oxide (NO) plays key signaling roles in the nervous systems, excess NO leads to cell death. In this study, the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and apoptosis signal-regulating kinase-1 (ASK1) in NO-induced cell death was investigated in PC12 cells. NO donor transiently activated p38 MAPK in the wild type parental PC12 cells, whereas the p38 MAPK activation was abolished in NO-resistant PC12 cells (PC 12-NO-R). p38 MAPK inhibitors protected the cells against NO-induced death, whereas the inhibitors were not significantly protective against the cytotoxicity of reactive oxygen species. Stable transfection with dominant negative p38 MAPK mutant reduced NO-induced cell death. Stable transfection with dominant negative mutant of ASK1 attenuated NO-stimulated activation of p38 MAPK and decreased NO-induced cell death. These results suggest that p38 MAPK and its upstream regulator ASK1 are involved in NO-induced PC12 cell death.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Han OJ,Joe KH,Kim SW,Lee HS,Kwon NS,Baek KJ,Yun HYdoi
10.1023/a:1010917129951keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
525-32issue
5eissn
0364-3190issn
1573-6903journal_volume
26pub_type
杂志文章abstract：:The real time dynamics of K+ evoked neurosecretion in cerebellar slices has been monitored electrochemically. In the presence of 5-methyltetrahydrofolate a statistically significant diminution in secretory response occurs. Agonists to probe the pharmacological basis for this indicate it is not due to voltage sensitive...
journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2015-03-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9213-9
更新日期：2007-02-01 00:00:00
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更新日期：2017-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1984-10-01 00:00:00
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更新日期：1991-01-01 00:00:00
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更新日期：2009-04-01 00:00:00
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更新日期：2008-09-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971368
更新日期：1987-01-01 00:00:00
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更新日期：2016-07-01 00:00:00
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更新日期：2007-07-01 00:00:00
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更新日期：1988-12-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2010-09-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1988-04-01 00:00:00
abstract：:The effect of maternal hypoxia on the modification of the fetal brain cell membrane N-methyl-D-aspartate (NMDA) receptor and its modulatory sites was investigated. Experiments were conducted in pregnant guinea pigs of 60 days of gestation. Guinea pig fetuses were exposed to maternal hypoxia (FiO2 = 7%) for 60 minutes....
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更新日期：1992-12-01 00:00:00
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更新日期：1988-09-01 00:00:00
abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...
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journal_title：Neurochemical research
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更新日期：2000-02-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1991-09-01 00:00:00
abstract：:Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...
journal_title：Neurochemical research
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更新日期：2020-12-01 00:00:00
abstract：:Evidence is presented in support of the working hypothesis that "prenervous" neurotransmitters directly participate in cell-cell interactions occurring during the first several cleavage divisions of sea urchin embryos, a function which may occur during the early development of higher animals as well. This intercellula...
journal_title：Neurochemical research
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doi：10.1007/BF00963906
更新日期：1981-01-01 00:00:00
