Abstract:
:The objective of the present study was to investigate the effects of senescence on the binding characteristics of muscarinic receptors by using [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine ([3H]NMS) as ligands in young (3 months), middle-age (10 months) and old (24 months) male Fischer 344 rats. Muscarinic receptor density was found to decrease significantly with aging in certain brain regions, depending on the ligand employed. Moreover, the relative proportions of M1 and M2 muscarinic receptor subtypes was not significantly altered by aging, except in the aged striatum. Furthermore, the dissociation kinetics of [3H]NMS in the cerebral cortex and their allosteric modulation by gallamine were only slightly influenced by age.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Surichamorn W,Kim ON,Lee NH,Lai WS,el-Fakahany EEdoi
10.1007/BF00971637subject
Has Abstractpub_date
1988-12-01 00:00:00pages
1183-91issue
12eissn
0364-3190issn
1573-6903journal_volume
13pub_type
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