Abstract:
:Methylguanidine (MG) is known as not only a nephrotoxin but also as a neurotoxine. We have previously showed that MG itself generates hydroxyl radicals (*OH) in an in vitro study. In this study, we examined the inhibitory effects of ascorbate, EPC-K(1) (alpha-tocopheryl-L-ascorbate-2-O-phosphate diester), Trolox (water-soluble vitamin E analogue), and glutathione (GSH) on *OH generation from MG using an electron spin resonance (ESR) spectrometry with spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). It was found that these compounds have potent inhibitory effect on *OH generation from MG in the order of ascorbate > GSH > EPC-K(1) > Trolox.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Noda Y,Mankura Mdoi
10.1007/s11064-008-9811-9subject
Has Abstractpub_date
2009-04-01 00:00:00pages
734-8issue
4eissn
0364-3190issn
1573-6903journal_volume
34pub_type
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