Molecular aspects of glutamate receptors and sodium-calcium exchange carriers in mammalian brain: implications for neuronal development and degeneration.

abstract：:Alzheimer's disease (AD) is the most common form of dementia that progressively disrupts neurocognitive function, which has neither cure nor effective treatment. Hypercholesterolemia might be involved in brain alterations that could evolve into AD. The present study aims to evaluate the potential of omega-3, Co-enzyme...

journal_title：Neurochemical research

authors： Ibrahim Fouad G

更新日期：2020-05-01 00:00:00

abstract：:Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in E1 mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug admi...

journal_title：Neurochemical research

authors： Hiramatsu M,Edamatsu R,Kabuto H,Higashihara Y,Mori A

更新日期：1989-01-01 00:00:00

abstract：:Members of the PDGF family have multiple roles during embryogenesis and in a variety of pathological situations in the adult. One of the major sites of PDGF-B expression in adult mammals are postmitotic CNS neurons. Combined with reported neurotrophic and neuroprotective effects of exogenously administered PDGFs, this...

journal_title：Neurochemical research

authors： Enge M,Wilhelmsson U,Abramsson A,Stakeberg J,Kühn R,Betsholtz C,Pekny M

更新日期：2003-02-01 00:00:00

abstract：:Impaired glucose transport across brain tissue barriers causes infantile seizures, developmental delay and acquired microcephaly. Since the first report in 1991 (De Vivo et al, NEJM, 1991) 17 patients have been identified with the glucose transporter protein syndrome (GTPS). The diagnostic feature of the syndrome is a...

journal_title：Neurochemical research

authors： Klepper J,Wang D,Fischbarg J,Vera JC,Jarjour IT,O'Driscoll KR,De Vivo DC

更新日期：1999-04-01 00:00:00

abstract：:The NG 108-15 (neuroblastoma X glioma hybrid) cell line was used as an in vitro neuronal model to evaluate potential antagonists of the Na+-selective carboxylic ionophore monensin. Changes in membrane electrical characteristics induced by monensin with and without the simultaneous administration of antagonists were me...

journal_title：Neurochemical research

authors： Doebler JA

更新日期：2000-07-01 00:00:00

abstract：:In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongat...

journal_title：Neurochemical research

authors： Manukian KH,Kirakosian LG

更新日期：1985-11-01 00:00:00

abstract：:Memory impairment is a major problem afflicting mankind. The association between memory functions and neurotransmitter functions is of great interest for understanding brain function. Serotonergic pathways play an important role in the modulation of memory functions but the importance of its receptor types and subtype...

journal_title：Neurochemical research

authors： Haider S,Khaliq S,Tabassum S,Haleem DJ

更新日期：2012-10-01 00:00:00

abstract：:Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...

journal_title：Neurochemical research

authors： Streck EL,Matte C,Vieira PS,Rombaldi F,Wannmacher CM,Wajner M,Wyse AT

更新日期：2002-12-01 00:00:00

abstract：:The human formyl peptide receptor like 1 (FPRL-1) is a variant of the Gi-coupled formyl-peptide receptor. Functional FPRL-1 is endogenously expressed in the U87 astrocytoma cell line and there is accumulating evidence to suggest that FPRL-1 may be involved in neuroinflammation associated with the pathogenesis of Alzhe...

journal_title：Neurochemical research

authors： Kwan DH,Kam AY,Wong YH

更新日期：2008-01-01 00:00:00

abstract：:The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostria...

journal_title：Neurochemical research

authors： Reader TA,Ase AR,Huang N,Hébert C,van Gelder NM

更新日期：1998-01-01 00:00:00

abstract：:Post-ischemic changes in energy metabolites and natural antioxidant compounds have been measured in rat brain in vitro concurrent with two different assays for peroxidized lipids. No exogenous free radical initiators were employed. In vitro oxygenation of minced brain preparations for periods of 10 minutes to 4 hours,...

journal_title：Neurochemical research

authors： Kogure K,Watson BD,Busto R,Abe K

更新日期：1982-04-01 00:00:00

abstract：:We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...

journal_title：Neurochemical research

authors： Herschman HR,Ferguson GD,Feldman JD,Farias-Eisner R,Vician L

更新日期：2000-05-01 00:00:00

abstract：:The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was fou...

journal_title：Neurochemical research

authors： Strunsky EG,Borisover MD,Nikolsky EE,Vyskocil F

更新日期：2001-09-01 00:00:00

abstract：:Recent evidence reveals that prolactin gene expression (PRL-GE) in mammotropes occurs in pulses, but the molecular process(es) underlying this phenomenon remains unclear. Earlier, we have identified an E-box (E-box133) in the rat PRL promoter that binds several circadian elements and is critical for this dynamic proce...

journal_title：Neurochemical research

authors： Bose S,Ganguly S,Kumar S,Boockfor FR

更新日期：2016-06-01 00:00:00

abstract：:The study provides detailed biochemical correlates to the common histopathological diagnoses in epilepsy. A dot immunobinding procedure was used for quantification of NSE, GFA, S-100, NCAM, NF 68 and NF 200. The material consisted of samples from 48 patients either selected for surgical treatment of partial epilepsy o...

journal_title：Neurochemical research

authors： Hamberger A,Bock E,Nordborg C,Nyström B,Silfvenius H,Wang S,Haglid KG

更新日期：1993-04-01 00:00:00

abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...

journal_title：Neurochemical research

authors： Redzic ZB,Malatiali SA,Al-Bader M,Al-Sarraf H

更新日期：2010-09-01 00:00:00

abstract：:Adaptive changes in serotonergic 5HT1 receptor signalling are believed to underlie the therapeutic effectiveness of antidepressant drugs. Since cells are continuously exposed to neurotransmitters/neuromodulators, spatially and temporally integrated, the responsiveness of a receptor system is dependent upon the physio-...

journal_title：Neurochemical research

authors： Trincavelli ML,Cuboni S,Montali M,Santaguida S,Lucacchini A,Martini C

更新日期：2008-07-01 00:00:00

abstract：:Exploring the neurochemical continuum between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with respect to monoamines and kynurenines in cerebrospinal fluid (CSF) and serum, may be useful to identify possible new research/therapeutic targets. Hence, we analysed monoamines and kynurenines in CS...

journal_title：Neurochemical research

authors： Janssens J,Vermeiren Y,van Faassen M,van der Ley C,Kema IP,De Deyn PP

更新日期：2020-05-01 00:00:00

abstract：:A prominent feature of brain pathology in Alzheimer's disease is a robust activation of the neuronal lysosomal system and major cellular pathways converging on the lysosome, namely, endocytosis and autophagy. Recent studies that identify a disturbance of the endocytic pathway as one of the earliest known manifestation...

journal_title：Neurochemical research

authors： Nixon RA,Cataldo AM,Mathews PM

更新日期：2000-10-01 00:00:00

abstract：:Activities toward arachidonyl-labelled phospholipase A2 substrates were assayed in fractions of white matter and cerebral cortex from control subjects and in fractions of demyelinated plaque, normal-appearing white matter and cerebral cortex from subjects who died with multiple sclerosis. Membranous activity at pH 8.6...

journal_title：Neurochemical research

authors： Huterer SJ,Tourtellotte WW,Wherrett JR

更新日期：1995-11-01 00:00:00

abstract：:It is well known that the principal biomolecules involved in Alzheimer's disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Aβ42). ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggr...

journal_title：Neurochemical research

authors： Méndez-Garrido A,Hernández-Rodríguez M,Zamorano-Ulloa R,Correa-Basurto J,Mendieta-Wejebe JE,Ramírez-Rosales D,Rosales-Hernández MC

更新日期：2014-11-01 00:00:00

abstract：:The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebe...

journal_title：Neurochemical research

authors： López-Colomé AM,Ortega A

更新日期：1997-06-01 00:00:00

abstract：:Pathogens such as bacterial lipopolysaccharide (LPS) play an important role in promoting the production of the inflammatory cytokines interleukin-1 beta (IL-1β) and tumour necrosis factor-α (TNF-α) in response to infection or damage in microglia. However, whether different signalling pathways regulate these two inflam...

journal_title：Neurochemical research

authors： Fu SY,Xiong RP,Peng Y,Zhang ZH,Chen X,Zhao Y,Ning YL,Yang N,Zhou YG,Li P

更新日期：2019-12-01 00:00:00

abstract：:The endogenous sialidase (N-acetylneuraminidase) activity of membranes prepared from goldfish retina and optic tectum displays characteristics similar to those reported for neural plasma membrane sialidases of other organisms. Endogenous membrane sialidase activity was found to be optimal at ph 4.0, and maximal releas...

journal_title：Neurochemical research

authors： Leskawa KC,Agranoff BW

更新日期：1983-01-01 00:00:00

abstract：:Neuropeptides are derived from large and inactive proteins which require endoproteolytic processing for the biosynthesis of the bioactive peptides. The maturation of pro-neuropeptide to neuropeptide is believed to be performed by ortholog pro-protein convertase EGL-3 in Caenorhabditis elegans (C. elegans). Furthermore...

journal_title：Neurochemical research

authors： Salem JB,Nkambeu B,Arvanitis DN,Beaudry F

更新日期：2018-11-01 00:00:00

abstract：:28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffeoyl triterpene with little information associated with its pharmacological target(s). To date no data is av...

journal_title：Neurochemical research

authors： Liu X,Ruan Z,Shao XC,Feng HX,Wu L,Wang W,Wang HM,Mu HY,Zhang RJ,Zhao WM,Zhang HY,Zhang NX

更新日期：2021-01-03 00:00:00

abstract：:GABAergic and cholinergic synaptosome populations were isolated by immunomagnetophoresis. Analysis of 8 amino acids showed that the GABAergic population was enriched in GABA (3 fold). The cholinergic population was enriched in citrulline (5 fold). CCK was found in both populations, but was enriched in the GABAergic. N...

journal_title：Neurochemical research

authors： Hughes PD,Foley P,Bradford HF,Ghatei M,Khandanian N,Bloom SR,Wu JY

更新日期：1993-04-01 00:00:00

abstract：:Chicken neurons in culture display measurable activities of mono- and diacylglycerol lipases. Treatment of chicken neuronal cultures with gangliosides (10(-8)M to 10(-5)M) resulted in a time and dose dependent increase in monoacylglycerol lipase activity. The diacylglycerol lipase showed significant increase in specif...

journal_title：Neurochemical research

authors： Freysz L,Farooqui AA,Horrocks LA,Massarelli R,Dreyfus H

更新日期：1991-11-01 00:00:00

abstract：:Oxidative stress is known to induce cell death in a wide variety of cell types, apparently by modulating intracellular signaling pathways. Activation of extracellular signal-regulated kinase (ERK) in oxidative stress remains controversial. In some cellular systems, the ERK activation is associated with protection agai...

journal_title：Neurochemical research

authors： Lee WC,Choi CH,Cha SH,Oh HL,Kim- YK

更新日期：2005-02-01 00:00:00

abstract：:Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...

journal_title：Neurochemical research

authors： Ma J,Cui B,Ding X,Wei J,Cui L

更新日期：2015-08-01 00:00:00