Uptake and metabolism of serotonin by ependymal primary cultures.

abstract：:Ion fluxes in mammalian myelinated axons are restricted to the nodes of Ranvier, where, in particular, voltage-gated Na+ channels are clustered at a high density. The node of Ranvier is separated from the internode by two distinct domains of the axolemma, the paranode and the juxtaparanode. Each axonal domain is chara...

journal_title：Neurochemical research

authors： Ishibashi T,Ikenaka K,Shimizu T,Kagawa T,Baba H

更新日期：2003-01-01 00:00:00

abstract：:Pig brain cerebral cortex was subfractionated by isopycnic centrifugation in sucrose gradients. In each subfraction the content of the agonist [3H]R-PIA binding, the activity of adenosine metabolizing enzymes (5'-nucleotidase and adenosine deaminase) and the activity of membrane marker enzymes were determined. The fra...

journal_title：Neurochemical research

authors： Casadó V,Lluis C,Canela E,Franco R,Mallol J

更新日期：1992-02-01 00:00:00

abstract：:Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...

journal_title：Neurochemical research

authors： Liu P,Zhao P,Li B,Xu D,Wang K

更新日期：2020-12-01 00:00:00

abstract：:Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major c...

journal_title：Neurochemical research

authors： Southwood CM,Peppi M,Dryden S,Tainsky MA,Gow A

更新日期：2007-02-01 00:00:00

abstract：:S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-t...

journal_title：Neurochemical research

authors： Nogueira MI,Abbas SY,Campos LG,Allemandi W,Lawson P,Takada SH,Azmitia EC

更新日期：2009-08-01 00:00:00

abstract：:The number of c-Fos protein-like immunoreactive (c-Fos-IR) neurons in the spinal dorsal horn evoked by noxious stimulation was previously shown to be increased following peripheral nerve injury, and this increase was proposed to reflect the neuropathic pain state. The aim of this study was to investigate whether anoma...

journal_title：Neurochemical research

authors： Terayama R,Kishimoto N,Yamamoto Y,Maruhama K,Tsuchiya H,Mizutani M,Iida S,Sugimoto T

更新日期：2015-03-01 00:00:00

abstract：:Deposition of amyloid beta peptide in human brain in the form of senile plaques is a neuropathological hallmark of Alzheimer's disease (AD). Levels of a phospholipid breakdown product, glycerophosphocholine (GPC), also increase in AD brain. The effect of GPC on amyloid beta(1-40) peptide (Abeta) aggregation in PBS buf...

journal_title：Neurochemical research

authors： Mandal PK,McClure RJ,Pettegrew JW

更新日期：2004-12-01 00:00:00

abstract：:The activities of L-glutamate decarboxylase (GAD), GABA-transaminase (GABA-T), choline acetyltransferase (CAT), and cysteic and cysteinesulfinic acids decarboxylase (CAD/CSAD) in putamen and frontal cortex in both Huntington's chorea and normal tissues were measured. The greatest difference between Huntington's and no...

journal_title：Neurochemical research

authors： Wu JY,Bird ED,Chen MS,Huang WM

更新日期：1979-10-01 00:00:00

abstract：:Endogenous phosphorylation of proteins from rat brain synaptosomal plasma membranes was studied in vitro. Cyclic AMP (cAMP) markedly stimulated(32)P incorporation in three protein bands with molecular weights of 75,000, 57,000, and 54,000, respectively. The effect of the behaviorally active peptide ACTH1-24 on this en...

journal_title：Neurochemical research

authors： Zwiers H,Veldhuis HD,Schotman P,Gispen WH

更新日期：1976-12-01 00:00:00

abstract：:Protocatechuic acid (PA), a major metabolite of anthocyanins, has been reported to possess antioxidant and anti-inflammatory activities. However, the effects of PA on LPS-induced inflammatory responses in microglia have not been reported. The aim of this study was to investigate the anti-inflammatory effects and molec...

journal_title：Neurochemical research

authors： Wang HY,Wang H,Wang JH,Wang Q,Ma QF,Chen YY

更新日期：2015-08-01 00:00:00

abstract：:Sleep disorders negatively affect cognition and health. Recent evidence has indicated that chromatin remodeling via histone acetylation regulates cognitive function. This study aimed to investigate the possible roles of histone acetylation in sleep deprivation (SD)-induced cognitive impairment. Results of the Morris w...

journal_title：Neurochemical research

authors： Duan R,Liu X,Wang T,Wu L,Gao X,Zhang Z

更新日期：2016-09-01 00:00:00

abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...

journal_title：Neurochemical research

authors： Bates DJ,Sirkos S,Moses EK,Austin L

更新日期：1983-03-01 00:00:00

abstract：:The efflux kinetics of 45Ca from rat brain cortex thin slices previously equilibrated with it, was studied in a superfusion system. Two first order kinetic components of efflux from the tissue were found: k2 = 0.0667 min-1, that was unchanged by lowering the temperature from 37 degrees C to 15 degrees, and k3 = 0.0167...

journal_title：Neurochemical research

authors： Rubiales de Barioglio S,Orrego F

更新日期：1982-11-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation,...

journal_title：Neurochemical research

authors： Wei N,Wei Y,Li B,Pang L

更新日期：2017-05-01 00:00:00

abstract：:Bovine brain synaptic membranes which were frozen and then extensively washed showed low affinity [3H]muscimol binding. These membranes contained GABA and calmodulin, apparently tightly bound within the membrane fraction. Membranes which were additionally treated with the detergent Triton X-100 showed high affinity [3...

journal_title：Neurochemical research

authors： O'Neill C,Williams DC

更新日期：1988-09-01 00:00:00

abstract：:Levels of free amino acids were determined quantitatively in whole ocular tissues of the rat eye with aid of a sensitive amino acid analyzer. The tissues studied were the retina, vitreous, lens, iris-ciliary body, and cornea. The retina and lens contained a more concentrated free amino acid pool than other tissues. Th...

journal_title：Neurochemical research

authors： Heinämäki AA,Muhonen AS,Piha RS

更新日期：1986-04-01 00:00:00

abstract：:Recent evidence suggests that young rodents submitted to high fructose (FRU) diet develop metabolic, and cognitive dysfunctions. However, it remains unclear whether these detrimental effects of FRU intake can also be observed in middle-aged mice. Nine months-old C57BL/6 female mice were fed with water (Control) or 10%...

journal_title：Neurochemical research

authors： Dos Santos B,Schmitz AE,de Almeida GRL,de Souza LF,Szczepanik JC,Nunes EA,Brunetta HS,Mack JM,Prediger RD,Cunha MP,Dafre AL

更新日期：2020-12-01 00:00:00

abstract：:Activities toward arachidonyl-labelled phospholipase A2 substrates were assayed in fractions of white matter and cerebral cortex from control subjects and in fractions of demyelinated plaque, normal-appearing white matter and cerebral cortex from subjects who died with multiple sclerosis. Membranous activity at pH 8.6...

journal_title：Neurochemical research

authors： Huterer SJ,Tourtellotte WW,Wherrett JR

更新日期：1995-11-01 00:00:00

abstract：:The phospholipid requirement for Ca2+-stimulated, Mg2+-dependent ATP hydrolysis (Ca2+/Mg2+-ATPase) and Mg2+-stimulated ATP hydrolysis (Mg2+-ATPase) in rat brain synaptosomal membranes was studied employing partial delipidation of the membranes with phospholipase A2 (Hog pancreas), phospholipase C (Bacillus cereus) and...

journal_title：Neurochemical research

authors： Gandhi CR,Ross DH

更新日期：1986-10-01 00:00:00

abstract：:Several lines of evidence indicate that ATP may play an important role in Long-Term Potentiation. In this investigation we evaluated the effect of a memory task (step-down inhibitory avoidance) on the synaptosomal ecto-enzymes (ATP diphosphohydrolase and 5'-nucleotidase) involved in the degradation of ATP to adenosine...

journal_title：Neurochemical research

authors： Bonan CD,Dias MM,Battastini AM,Dias RD,Sarkis JJ

更新日期：1998-07-01 00:00:00

abstract：:The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore established sensitive quantification methods and provided a rat ICH model for detection of ICH deterioration. In ICH intrastriatally induced by 0.014-unit, 0.070-unit, and 0.350-unit co...

journal_title：Neurochemical research

authors： Terai K,Suzuki M,Sasamata M,Miyata K

更新日期：2003-05-01 00:00:00

abstract：:Using the immunoblot technique, we found that an incubation of purified human myelin in 10 mM Tris-HCl buffer at pH 7.5 resulted in the conversion of the myelin-associated glycoprotein (MAG) to a smaller derivative (dMAG). Exogenously added 5 mM CaCl2 accelerated the conversion of MAG. In buffer containing more than 1...

journal_title：Neurochemical research

authors： Sato S,Yanagisawa K,Miyatake T

更新日期：1984-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visua...

journal_title：Neurochemical research

authors： Parambi DGT,Saleem U,Shah MA,Anwar F,Ahmad B,Manzar A,Itzaz A,Harilal S,Uddin MS,Kim H,Mathew B

更新日期：2020-11-01 00:00:00

abstract：:1-Methyl-4-phenylpyridinium (MPP(+)) or 6-hydroxydopamine (6-OHDA) caused a nuclear damage, the mitochondrial membrane permeability changes, leading to the cytochrome c release and caspase-3 activation, the formation of reactive oxygen species and the depletion of GSH in PC12 cells. Nicardipine (a calcium channel bloc...

journal_title：Neurochemical research

authors： Lee DH,Han YS,Han ES,Bang H,Lee CS

更新日期：2006-07-01 00:00:00

abstract：:(E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine (HOEC), a naturally caffeic ester isolated from Incarvillea mairei, has been reported to possess anti-inflammatory activity by targeting 5-lipoxygenase. However, its other potential activities have yet to be explored. In this study, we measured antioxidant activity of ...

journal_title：Neurochemical research

authors： Chen B,Yue R,Yang Y,Zeng H,Chang W,Gao N,Yuan X,Zhang W,Shan L

更新日期：2015-03-01 00:00:00

abstract：:Astrocytes transport the monocarboxylate acetate, but synaptosomes do not. The reason for this is unknown, because both preparations express monocarboxylate transporters (MCT). The transport and metabolism of lactate, another monocarboxylate, was examined in these two preparations, and the results were compared to tho...

journal_title：Neurochemical research

authors： Waniewski RA,Martin DL

更新日期：2004-01-01 00:00:00

abstract：:Rats fed a vitamin E-deficient diet for 7--8 weeks postweaning showed no change in brain weight or the activity in brain of various enzymes involved in neurotransmitter synthesis and metabolism. Body and muscle weights were markedly reduced. Muscle choline acetyltransferase and acetylcholinesterase activities were sig...

journal_title：Neurochemical research

authors： Sung SC,Sandberg PR,McGeer EG

更新日期：1978-12-01 00:00:00

abstract：:We have previously shown that extracellular ATP caused cell death in PC12 cells through activation of its receptors. Oxidative stress has been implicated as a mechanism of cell death caused by extracellular ATP. In the present study we examined the possible signal transduction cascades leading to cell death by extrace...

journal_title：Neurochemical research

authors： Chen Y,Sun AY

更新日期：1998-04-01 00:00:00

abstract：:We propose the following scheme for cerebral uptake and overall metabolism of glucose in vivo: that brain selects from two pools of glucose anomers in arterial blood, that it takes up excess glucose, that glucose enters the brain tissue as glucose-6-phosphate through the actions of mutarotase and hexokinase, that some...

journal_title：Neurochemical research

authors： Sacks W,Cowburn D,Bigler RE,Sacks S,Fleischer A

更新日期：1985-02-01 00:00:00

abstract：:The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...

journal_title：Neurochemical research

authors： Saransaari P,Oja SS

更新日期：2008-03-01 00:00:00