Abstract:
:The effects of a number of drugs that deplete catecholamines or block their receptors were investigated on the levels of free amino acids and glutamate decarboxylase activity in rat striatum and substantia nigra, in an attempt to clarify the possible links between catecholamine and amino acid transmitter function. While none of the drugs tested were significantly active in the striatum, profound changes occurred in the substantia nigra. The data are discussed in relation to the possible mechanisms involved.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Roberts PJ,Kapur Hdoi
10.1007/BF00966009subject
Has Abstractpub_date
1977-10-01 00:00:00pages
485-94issue
5eissn
0364-3190issn
1573-6903journal_volume
2pub_type
杂志文章abstract::Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973648
更新日期:1990-07-01 00:00:00
abstract::The effect of castration on the levels of brain monoamines and their metabolites has been investigated in rats which became or did not become muricidal following long-term isolation. Fourteen brain areas were explored: olfactory bulbs (OB), olfactory tubercles (OT), septum (Se), striatum (Sr), amygdala (A), thalamus (...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967251
更新日期:1993-04-01 00:00:00
abstract::The efflux kinetics of 45Ca from rat brain cortex thin slices previously equilibrated with it, was studied in a superfusion system. Two first order kinetic components of efflux from the tissue were found: k2 = 0.0667 min-1, that was unchanged by lowering the temperature from 37 degrees C to 15 degrees, and k3 = 0.0167...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966071
更新日期:1982-11-01 00:00:00
abstract::Discrete populations of anti-S49 antibodies were found in the antisera of Lewis rats recovered from S49-induced experimental allergic encephalomyelitis (EAE). A potent inducer of EAE in Lewis rats, S49 is a synthetic peptide representing residues 69-84 of bovine myelin basic protein but with deletions at Gly-77 and Hi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00988601
更新日期:1985-12-01 00:00:00
abstract::Alpha adrenergic receptor subtypes in rat hippocampal membranes were studied, using [3H] clonidine as the radioactive ligand. On the basis of competitive binding studies, using the selective antagonist-prazosin, WB-4101, and yohimbine, [3H] clonidine appeared to bind to a population of presynaptic sites that are pharm...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965058
更新日期:1982-02-01 00:00:00
abstract::A rapid and specific method for assaying 4-aminobutyrate-2-oxoglutarate aminotransferase was developed. The method was based on the selectivity of ion exchange resin and the speed of vacuum filtration. With this new method, the aminotransferase activity in various tissues has been determined as follows: brain, 10.2; s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964061
更新日期:1978-04-01 00:00:00
abstract::Heme oxygenase-1 (HO-1) plays a crucial role in oxidative stress processes, apoptosis and cell differentiation. Further, some proteins related to cell cycle including cyclins and p21 are important markers of astrocyte cultures. Aim of investigation was to study the effects of cholinergic precursors (choline, CDP-choli...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0873-3
更新日期:2012-12-01 00:00:00
abstract::The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are al...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF02529142
更新日期:1996-02-01 00:00:00
abstract::Several epidemiological studies have shown that consumption of large quantities of vegetables especially cruciferous vegetables (Broccoli and Brussels sprouts) can protect against chronic diseases. Sulforaphane, an isothiocynate found in cruciferous vegetables has been demonstrated to have neuroprotective effects in s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1965-2
更新日期:2016-10-01 00:00:00
abstract::A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966022
更新日期:1977-02-01 00:00:00
abstract::Gelsolin is an actin regulatory protein that generally distributed in a wide variety of body tissues, especially the brain tissues and cerebrospinal fluid. In this study we found that lumbar CSF-gelsolin concentrations markedly decreased in epileptic patients by enzyme linked immunosorbent assay. In order to help judg...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0549-4
更新日期:2011-12-01 00:00:00
abstract::Acidosis (pH 6.0) led to significant decrease in high-affinity choline uptake by rat brain synaptosomes. The effects persisted following pH readjustment (7.4) of the incubation medium, consisting of decrease in both Km and Vmax of the affinity system. pH readjustment coincided with synaptosomal leakage of lactate dehy...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969699
更新日期:1995-07-01 00:00:00
abstract::Factors secreted by C6 glioma cells which induce electrical resistances across endothelial monolayers in an in vitro blood-brain barrier model have been partially characterised for the first time. These transendothelial electrical resistances (TEERs) were only evident when cell-free conditioned medium derived from C6 ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020932121378
更新日期:1998-12-01 00:00:00
abstract::We have previously shown that extracellular ATP caused cell death in PC12 cells through activation of its receptors. Oxidative stress has been implicated as a mechanism of cell death caused by extracellular ATP. In the present study we examined the possible signal transduction cascades leading to cell death by extrace...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022438703271
更新日期:1998-04-01 00:00:00
abstract::We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1026670620633
更新日期:2000-12-01 00:00:00
abstract::Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is known about this important topic. In the present study, we investigated the effects of hyperthermia on the protect...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0327-8
更新日期:2011-02-01 00:00:00
abstract::Previous studies have shown that early life stress induced by maternal separation or non-handling can lead to behavioural deficits in rats and that these deficits can be alleviated by providing palatable cafeteria high-fat diet (HFD). In these studies we investigated the effects of maternal separation or non-handling ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-0985-4
更新日期:2013-04-01 00:00:00
abstract::Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous entity to a destructive one. The amino acid D-serine over the last 25 years has "shape-shifted" into several identities: a purported glial transmitter activating N-...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-020-03014-1
更新日期:2020-06-01 00:00:00
abstract::The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines. VRI protein was de...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000018839.59457.5c
更新日期:2004-04-01 00:00:00
abstract::Levels of free amino acids were determined quantitatively in whole ocular tissues of the rat eye with aid of a sensitive amino acid analyzer. The tissues studied were the retina, vitreous, lens, iris-ciliary body, and cornea. The retina and lens contained a more concentrated free amino acid pool than other tissues. Th...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965323
更新日期:1986-04-01 00:00:00
abstract::Methylguanidine (MG) is known as not only a nephrotoxin but also as a neurotoxine. We have previously showed that MG itself generates hydroxyl radicals (*OH) in an in vitro study. In this study, we examined the inhibitory effects of ascorbate, EPC-K(1) (alpha-tocopheryl-L-ascorbate-2-O-phosphate diester), Trolox (wate...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9811-9
更新日期:2009-04-01 00:00:00
abstract::In the unrestrained rat, the hyperphagic-like ingestion of food evoked by the sustained elevation of neuropeptide-Y (NPY) in the hypothalamus was correlated with the release and turnover of monoaminergic transmitters in this structure. A single guide tube was implanted stereotaxically in the perifornical region of the...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967290
更新日期:1992-11-01 00:00:00
abstract::Several previous studies utilizing selective pharmacological antagonists have demonstrated that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for the treatment of numerous disorders of the central nervous system, but the role of mGluR5 activation in traumatic brain injury (TBI) is ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0691-z
更新日期:2012-05-01 00:00:00
abstract::During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1545-x
更新日期:2015-12-01 00:00:00
abstract::Specific [3H]MK801 binding to rat brain NMDA receptors after the administration of the convulsant drug 3-mercaptopropionic acid (MP) and the adenosine analogue cyclopentyladenosine (CPA) was studied by means of a quantitative autoradiographic method. MP administration (150 mg/kg, i.p.) caused significant decreases in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020708603495
更新日期:1998-10-01 00:00:00
abstract::Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968084
更新日期:1984-12-01 00:00:00
abstract::The effect of anticonvulsant drugs was examined on brain GABA levels and GAD and GABA-T activities. The level of GABA was increased by the treatment with diphenylhydantoin. The drug had no effect on GABA-T activity, whereas GAD activity was inhibited. Carbamazepine increased the GABA level but did not effect GAD and G...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964170
更新日期:1984-02-01 00:00:00
abstract::Exposure chronically to n-hexane produces peripheral-central axonopathy mediated by 2,5-hexanedione (HD). Previous studies have demonstrated decreases in neurofilament (NF) contents of peripheral and central nervous regions from rats intoxicated with HD, and recent analysis has demonstrated that axonal atrophy, instea...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-004-2439-5
更新日期:2005-02-01 00:00:00
abstract::Secretases degrade amyloid precursor protein (APP) releasing fragments (beta-peptides A beta, A beta x) that assemble to form hallmark extracellular deposits in Alzheimer's disease (AD) correlating with disease severity. As such, secretases supply targets for therapeutic intervention and form the focus of this overvie...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1023211323853
更新日期:2003-07-01 00:00:00
abstract::Lesions of the nigrostriatal pathway are known to induce a compensatory up-regulation of various neurotrophic factors. In this study we examined protein content of basic fibroblast growth factor (FGF-2) in tissue samples taken from the ventral midbrain and striatum at two different time points following a neurotoxic l...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-0093-7
更新日期:2010-04-01 00:00:00