Exosomes in Alzheimer's Disease: Potential Role as Pathological Mediators, Biomarkers and Therapeutic Targets.

Abstract:

:The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration and neuronal loss, exosomes were shown to be involved in carrying pathological misfolded proteins, propagation of β-amyloid protein and hyper-phosphorylated tau proteins across the brain that ultimately leads to the onset of Alzheimer's disease (AD), the most prevailing multifactorial neurodegenerative disorder. A potential novel therapeutic role of exosomes in AD intervention is suggested by their ability to increase Aβ clearance. This review aims to highlight the important pathological mechanisms as well as therapeutic strategies involving exosomes towards AD prevention.

journal_name

Neurochem Res

journal_title

Neurochemical research

authors

Lakshmi S,Essa MM,Hartman RE,Guillemin GJ,Sivan S,Elumalai P

doi

10.1007/s11064-020-03111-1

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

2553-2559

issue

11

eissn

0364-3190

issn

1573-6903

pii

10.1007/s11064-020-03111-1

journal_volume

45

pub_type

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