Abstract:
:The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration and neuronal loss, exosomes were shown to be involved in carrying pathological misfolded proteins, propagation of β-amyloid protein and hyper-phosphorylated tau proteins across the brain that ultimately leads to the onset of Alzheimer's disease (AD), the most prevailing multifactorial neurodegenerative disorder. A potential novel therapeutic role of exosomes in AD intervention is suggested by their ability to increase Aβ clearance. This review aims to highlight the important pathological mechanisms as well as therapeutic strategies involving exosomes towards AD prevention.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Lakshmi S,Essa MM,Hartman RE,Guillemin GJ,Sivan S,Elumalai Pdoi
10.1007/s11064-020-03111-1subject
Has Abstractpub_date
2020-11-01 00:00:00pages
2553-2559issue
11eissn
0364-3190issn
1573-6903pii
10.1007/s11064-020-03111-1journal_volume
45pub_type
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