Electrical stimulation induces calcium-dependent neurite outgrowth and immediate early genes expressions of dorsal root ganglion neurons.

abstract：:The role of protein phosphorylation in catecholamine secretion from bovine adrenomedullary chromaffin cells was studied using different protein kinase inhibitors. Naphthalenesulfonamide derivatives as ML9 and ML7, more specific for the myosin light chain kinase, and the calmodulin antagonist W7 inhibited catecholamine...

journal_title：Neurochemical research

authors： Reig JA,Viniegra S,Ballesta JJ,Palmero M,Guitierrez LM

更新日期：1993-03-01 00:00:00

abstract：:Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...

journal_title：Neurochemical research

authors： Lin SS,Hung CF,Ho CC,Liu YH,Ho HC,Chung JG

更新日期：2000-11-01 00:00:00

abstract：:Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...

journal_title：Neurochemical research

authors： Galoyan AA,Gurvitz BYa,Sharova NP

更新日期：1989-12-01 00:00:00

abstract：:The study examined (a) whether there is sex difference in spinal cord and plasma oxidative stress profiles in Dark Agouti rats immunised for experimental autoimmune encephalomyelitis (EAE), the principal experimental model of multiple sclerosis, and (b) whether there is correlation between the oxidative stress in spin...

journal_title：Neurochemical research

authors： Dimitrijević M,Kotur-Stevuljević J,Stojić-Vukanić Z,Vujnović I,Pilipović I,Nacka-Aleksić M,Leposavić G

更新日期：2017-02-01 00:00:00

abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...

journal_title：Neurochemical research

authors： Long Y,Zhuang K,Ji Z,Han Y,Fei Y,Zheng W,Song Z,Yang H

更新日期：2019-04-01 00:00:00

abstract：:In membranes of rat striatum, phorbol 12-myristate 13-acetate (PMA), a potent activator of Ca2+/phospholipid-dependent protein kinase, enhanced adenylate cyclase activity by counteracting the inhibition elicited by GTP. Exposure to pertussis toxin caused a similar alteration of the GTP-regulation of the enzyme activit...

journal_title：Neurochemical research

authors： Olianas MC,Onali P

更新日期：1990-11-01 00:00:00

abstract：:5- and 6-Hydroxydopamine, which we had earlier identified as naturally occurring amines in human urine, were quantified in Parkinson's patients treated with L-DOPA, Parkinson's patients whose treatment did not include L-DOPA and in age matched controls. Analysis was carried out by GC-MS of the ditrifluoromethylbenzoyl...

journal_title：Neurochemical research

authors： Andrew R,Watson DG,Best SA,Midgley JM,Wenlong H,Petty RK

更新日期：1993-11-01 00:00:00

abstract：:Reserpine evokes transsynaptic impulse activity by depleting catecholaminergic neurotransmitters in the rat brain. Previous studies suggest a relationship between catecholaminergic activity and calmodulin concentration. In this report we employ Northern blot analysis to examine the effect of a single subcutaneous inje...

journal_title：Neurochemical research

authors： Ni B,Brown IR

更新日期：1993-02-01 00:00:00

abstract：:Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to ...

journal_title：Neurochemical research

authors： Aguilar JS,Ballesta JJ,Reig JA,Palmero M,Viniegra S,Criado M

更新日期：1992-12-01 00:00:00

abstract：:Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...

journal_title：Neurochemical research

authors： Pastuszko P,Schears GJ,Greeley WJ,Kubin J,Wilson DF,Pastuszko A

更新日期：2014-11-01 00:00:00

abstract：:This investigation was performed to evaluate the effects of ACPD [(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid], a metabotropic glutamate receptor agonist, on cerebral O2 consumption during focal cerebral ischemia. Male Wistar rats were placed in control (n = 7) and ACPD (n = 7) groups under isoflurane anesthesia...

journal_title：Neurochemical research

authors： Liu X,Chi OZ,Weiss HR

更新日期：2003-12-01 00:00:00

abstract：:Protein misfolding and deposition in the brain are implicated in the etiology of numerous neurodegenerative disorders. Here, organic solutes characteristic of microorganisms adapted to hot environments, were tested on experimental cell models of Huntington's and Parkinson's diseases. Diglycerol phosphate, di-myo-inosi...

journal_title：Neurochemical research

authors： Jorge CD,Ventura R,Maycock C,Outeiro TF,Santos H,Costa J

更新日期：2011-06-01 00:00:00

abstract：:The pathophysiology of cerebral oedema (CE) in diabetic ketoacidosis (DKA) remains enigmatic. We investigated the role of the idiogenic osmol taurine and aquaporin channels in an in vitro model, the SH-SY5Y neuroblastoma cell line, by sequentially mimicking DKA-like hyperglycemia/hypertonicity and hypotonic fluid ther...

journal_title：Neurochemical research

authors： Koves IH,Russo VC,Higgins S,Mishra A,Pitt J,Cameron FJ,Werther GA

更新日期：2012-01-01 00:00:00

abstract：:Excitotoxicity has been associated with the loss of medium spiny neurons (MSN) in Huntington's disease (HD). We have previously observed that the content of the glial glutamate transporters, glutamate transporter 1 (GLT-1) and glutamate-aspartate transporter (GLAST), diminishes in R6/2 mice at 14 weeks of age but not ...

journal_title：Neurochemical research

authors： Estrada-Sánchez AM,Montiel T,Massieu L

更新日期：2010-08-01 00:00:00

abstract：:A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...

journal_title：Neurochemical research

authors： Rostas JA,Jeffrey PL

更新日期：1977-02-01 00:00:00

abstract：:Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...

journal_title：Neurochemical research

authors： Goldberg WJ,Watson BD,Busto R,Kurchner H,Santiso M,Ginsberg MD

更新日期：1984-12-01 00:00:00

abstract：:With the aid of histochemical and electrophoretic techniques activities for esterase and esterprotease were investigated in the digastric and masseter muscles from normal and dystrophic mice. The substrates used were alpha-naphthyl acetate and N-acetyl-L-alanine alpha-naphthyl ester. According to the microscopic obser...

journal_title：Neurochemical research

authors： Kirkeby S,Moe D,Vilmann H

更新日期：1989-03-01 00:00:00

abstract：:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) an...

journal_title：Neurochemical research

authors： Hermann A,Varga V,Janáky R,Dohovics R,Saransaari P,Oja SS

更新日期：2000-08-01 00:00:00

abstract：:It is well known that the principal biomolecules involved in Alzheimer's disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Aβ42). ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggr...

journal_title：Neurochemical research

authors： Méndez-Garrido A,Hernández-Rodríguez M,Zamorano-Ulloa R,Correa-Basurto J,Mendieta-Wejebe JE,Ramírez-Rosales D,Rosales-Hernández MC

更新日期：2014-11-01 00:00:00

abstract：:Implication of protein phosphatases in Alzheimer disease led us to a systemic investigation of the identification of these enzyme activities in human brain. Human brain phosphatases eluted from DEAE-Sephacel with 0.22 M NaCl were resolved into two main groups by affi-gel blue chromatography, namely affi-gel blue-bindi...

journal_title：Neurochemical research

authors： Cheng LY,Wang JZ,Gong CX,Pei JJ,Zaidi T,Grundke-Iqbal I,Iqbal K

更新日期：2000-01-01 00:00:00

abstract：:The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic ac...

journal_title：Neurochemical research

authors： Szabó G,Kovács GL,Baláspiri L,Telegdy G

更新日期：1986-12-01 00:00:00

abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...

journal_title：Neurochemical research

authors： Strosznajder JB,Cieslik M,Cakala M,Jesko H,Eckert A,Strosznajder RP

更新日期：2011-05-01 00:00:00

abstract：:It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...

journal_title：Neurochemical research

authors： Li J,Yu T,Shi F,Zhang Y,Duan Z,Fu B,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:Microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as Alzheimer disease. Mounting evidence points to ion channels expressed by microglia as contributing to these neuropathologies. The Chloride Intracellular Channel (CLIC) family represent...

journal_title：Neurochemical research

authors： Skaper SD,Facci L,Giusti P

更新日期：2013-09-01 00:00:00

abstract：:Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress....

journal_title：Neurochemical research

authors： Finamor IA,Ourique GM,Pês TS,Saccol EM,Bressan CA,Scheid T,Baldisserotto B,Llesuy SF,Partata WA,Pavanato MA

更新日期：2014-09-01 00:00:00

abstract：:We investigated the action of the new hypothalamic proline-rich peptide (PRP-1), normally produced by neurosecretory cells of hypothalamic nuclei (NPV and NSO), 3 and 4 weeks following rat sciatic nerve transection. The impulse activity flow of interneurons (IN) and motoneurons (MN) on stimulation of mixed (n. ischiad...

journal_title：Neurochemical research

authors： Galoyan AA,Sarkissian JS,Sulkhanyan RM,Chavushyan VA,Avetisyan ZA,Avakyan ZE,Gevorgyan AJ,Abrahamyan DO,Grigorian YKh

更新日期：2005-04-01 00:00:00

abstract：:cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold or greater difference in normalized expression. RT-PCR analysis of a s...

journal_title：Neurochemical research

authors： Conn KJ,Ullman MD,Larned MJ,Eisenhauer PB,Fine RE,Wells JM

更新日期：2003-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a common progressive neurodegenerative disorder, for which at present no causal treatment is available. On the understanding that the causes of PD are mainly oxidative stress and mitochondrial dysfunction, antioxidants and other drugs are expected to be used. In the present study, we demons...

journal_title：Neurochemical research

authors： Jimenez-Del-Rio M,Guzman-Martinez C,Velez-Pardo C

更新日期：2010-02-01 00:00:00

abstract：:The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostria...

journal_title：Neurochemical research

authors： Reader TA,Ase AR,Huang N,Hébert C,van Gelder NM

更新日期：1998-01-01 00:00:00

abstract：:α-Synuclein (α-Syn) plays a crucial role in the pathophysiology of Parkinson's disease (PD), the degeneration of dopaminergic neurons. Previous studies have shown that α-Syn regulates dopamine synthesis by binding to and inhibiting tyrosine hydroxylase (TH). In neurons, protein phosphatases (PPs) play a prominent role...

journal_title：Neurochemical research

authors： Hua G,Xiaolei L,Weiwei Y,Hao W,Yuangang Z,Dongmei L,Yazhuo Z,Hui Y

更新日期：2015-03-01 00:00:00